Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 305 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q3 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 264
- +41 vs. Q2 2025
- Shares held
- 70.9M
- +4.57M (+6.9%) vs. Q2 2025
- Total value
- $7.20B
- +$3.01B (+71.8%) vs. Q2 2025
- New holders
- 57
- 99 more added
- Sold out
- 16
- 82 more reduced
4 institutions that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 305 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Hillsdale Investment Management Inc. | 42,600 | $4.30M | 0.13% | +42,600 | New |
| Castleark Management LLC | 42,539 | $4.30M | 0.12% | +42,539 | New |
| Aquatic Capital Management LLC | 42,490 | $4.29M | 0.08% | +38,537+974.9% | Added |
| State of Wisconsin Investment Board | 40,776 | $4.12M | 0.01% | +5,068+14.2% | Added |
| Kennedy Capital Management, Inc. | 39,575 | $4.00M | 0.09% | −17,642−30.8% | Reduced |
| HighVista Strategies LLC | 37,482 | $3.79M | 0.93% | +9,414+33.5% | Added |
| Harbor Capital Advisors, Inc. | 37,205 | $3.76M | 0.29% | −49,341−57.0% | Reduced |
| Trexquant Investment LP | 37,161 | $3.75M | 0.04% | +30,078+424.7% | Added |
| Canada Pension Plan Investment Board | 37,000 | $3.74M | 0.00% | +37,000 | New |
| Cinctive Capital Management LP | 35,156 | $3.55M | 0.18% | −35,781−50.4% | Reduced |
| Jain Global LLC | 35,110 | $3.55M | 0.05% | +31,202+798.4% | Added |
| Rhenman & Partners Asset Management AB | 35,000 | $3.53M | 0.39% | +35,000 | New |
| Silvercrest Asset Management Group LLC | 34,084 | $3.44M | 0.02% | −14,691−30.1% | Reduced |
| Alps Advisors Inc | 33,000 | $3.33M | 0.02% | −1,178−3.4% | Reduced |
| SEI Investments Co | 31,658 | $3.20M | 0.00% | −1,487−4.5% | Reduced |
| Penserra Capital Management LLC | 30,436 | $3.07M | 0.04% | +30,436 | New |
| MetLife Investment Management | 30,362 | $3.07M | 0.01% | −2,033−6.3% | Reduced |
| Samsara BioCapital, LLC | 30,285 | $3.06M | 0.40% | −20,191−40.0% | Reduced |
| Lazard Asset Management LLC | 30,239 | $3.05M | 0.00% | −69,206−69.6% | Reduced |
| Dark Forest Capital Management LP | 28,639 | $2.89M | 0.11% | −6,190−17.8% | Reduced |
| Dimensional Fund Advisors LP | 28,378 | $2.87M | 0.00% | +28,378 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 27,122 | $2.74M | 0.00% | −5,229−16.2% | Reduced |
| Voleon Capital Management LP | 26,897 | $2.72M | 0.07% | +26,897 | New |
| Standard Life Aberdeen plc | 26,740 | $2.70M | 0.00% | −40,917−60.5% | Reduced |
| Creative Planning | 24,945 | $2.52M | 0.00% | +7,723+44.8% | Added |
| Wellington Management Group LLP | 24,477 | $2.47M | 0.00% | +2,052+9.2% | Added |
| Intech Investment Management LLC | 24,312 | $2.46M | 0.02% | −3,131−11.4% | Reduced |
| Wedge Capital Management L L P | 22,244 | $2.25M | 0.04% | −7,747−25.8% | Reduced |
| State of New Jersey Common Pension Fund D | 20,919 | $2.11M | 0.01% | −9,454−31.1% | Reduced |
| EFG Asset Management (North America) Corp. | 20,269 | $2.05M | 0.26% | +20,269 | New |
| Burkehill Global Management, LP | 20,000 | $2.02M | 0.11% | +20,000 | New |
| SG Americas Securities, LLC | 19,554 | $1.98M | 0.01% | +13,369+216.2% | Added |
| Captrust Financial Advisors | 18,258 | $1.84M | 0.00% | +787+4.5% | Added |
| Schroder Investment Management Group | 18,042 | $1.82M | 0.00% | +424+2.4% | Added |
| Quantedge Capital Pte Ltd | 17,800 | $1.80M | 0.98% | +17,800 | New |
| Los Angeles Capital Management LLC | 16,721 | $1.69M | 0.01% | +12,849+331.8% | Added |
| Arizona State Retirement System | 15,614 | $1.58M | 0.01% | +1,780+12.9% | Added |
| Handelsbanken Fonder AB | 15,521 | $1.57M | 0.00% | 00.0% | Unchanged |
| STRS Ohio | 14,800 | $1.49M | 0.01% | −2,600−14.9% | Reduced |
| State Board of Administration of Florida Retirement System | 14,650 | $1.48M | 0.00% | −20−0.1% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 14,606 | $1.48M | 0.01% | +2,247+18.2% | Added |
| Stifel Financial Corp | 14,455 | $1.46M | 0.00% | −3,722−20.5% | Reduced |
| Great West Life Assurance Co | 14,395 | $1.45M | 0.00% | +2,817+24.3% | Added |
| Advisors Asset Management, Inc. | 14,178 | $1.43M | 0.02% | +582+4.3% | Added |
| Engineers Gate Manager LP | 13,775 | $1.39M | 0.02% | −3,901−22.1% | Reduced |
| Nisa Investment Advisors, LLC | 13,254 | $1.34M | 0.01% | +12,000+956.9% | Added |
| Citigroup Inc | 13,080 | $1.32M | 0.00% | −21,244−61.9% | Reduced |
| Teacher Retirement System of Texas | 12,960 | $1.31M | 0.01% | +188+1.5% | Added |
| Principal Financial Group Inc | 12,598 | $1.27M | 0.00% | −469−3.6% | Reduced |
| Profund Advisors LLC | 12,457 | $1.26M | 0.04% | +1,203+10.7% | Added |
| Fred Alger Management, LLC | 12,335 | $1.25M | 0.00% | +12,335 | New |
| Allianz Asset Management GmbH | 12,100 | $1.22M | 0.00% | 00.0% | Unchanged |
| SummitTX Capital, L.P. | 11,869 | $1.20M | 0.05% | −13,583−53.4% | Reduced |
| China Universal Asset Management Co., Ltd. | 11,642 | $1.18M | 0.10% | −1,136−8.9% | Reduced |
| ProShare Advisors LLC | 11,299 | $1.14M | 0.00% | −2,237−16.5% | Reduced |
| KLP Kapitalforvaltning AS | 11,000 | $1.11M | 0.00% | +800+7.8% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,726 | $1.08M | 0.00% | +1,074+11.1% | Added |
| Fiduciary Trust Co | 10,000 | $1.01M | 0.01% | 00.0% | Unchanged |
| Toth Financial Advisory Corp | 10,000 | $1.01M | 0.11% | 00.0% | Unchanged |
| Cannon Financial Strategists, Inc. | 10,000 | $1.01M | 0.14% | 00.0% | Unchanged |
| Bellevue Group AG | 9,053 | $914.3K | 0.02% | −11,853−56.7% | Reduced |
| Rockefeller Capital Management L.P. | 8,868 | $895.6K | 0.00% | +8,868 | New |
| Entropy Technologies, LP | 8,502 | $858.6K | 0.06% | +8,502 | New |
| Readystate Asset Management LP | 8,365 | $844.8K | 0.04% | −16,301−66.1% | Reduced |
| Aigen Investment Management, LP | 8,225 | $830.6K | 0.13% | +4,011+95.2% | Added |
| E. Ohman J:or Asset Management AB | 8,213 | $829.4K | 0.02% | 00.0% | Unchanged |
| Leo Wealth, LLC | 7,867 | $794.5K | 0.10% | −5,578−41.5% | Reduced |
| Inceptionr LLC | 7,482 | $755.6K | 0.18% | +7,482 | New |
| Virtus Investment Advisers, Inc. | 7,052 | $712.2K | 0.20% | 00.0% | Unchanged |
| Virginia Retirement Systems Et Al | 6,700 | $676.6K | 0.00% | +6,700 | New |
| Exchange Traded Concepts, LLC | 6,386 | $644.9K | 0.01% | +6,386 | New |
| Arrowstreet Capital, Limited Partnership | 6,307 | $636.9K | 0.00% | +6,307 | New |
| Jasper Ridge Partners, L.P. | 5,639 | $569.5K | 0.01% | 00.0% | Unchanged |
| CIBC Bancorp USA Inc. | 5,569 | $562.4K | 0.00% | +5,569 | New |
| Oxford Asset Management LLP | 5,538 | $559.3K | 0.18% | +5,538 | New |
| DnB Asset Management AS | 5,528 | $558.3K | 0.00% | +5,528 | New |
| Public Employees Retirement Association of Colorado | 5,463 | $552.0K | 0.00% | 00.0% | Unchanged |
| Quantbot Technologies LP | 4,981 | $503.0K | 0.01% | +4,981 | New |
| Gotham Asset Management, LLC | 4,855 | $490.3K | 0.00% | +4+0.1% | Added |
| O'Shaughnessy Asset Management, LLC | 4,836 | $488.4K | 0.00% | +1,360+39.1% | Added |
| Mackenzie Financial Corp | 4,398 | $444.2K | 0.00% | −13−0.3% | Reduced |
| Ameritas Investment Partners, Inc. | 4,365 | $440.8K | 0.01% | −1,181−21.3% | Reduced |
| The PNC Financial Services Group, Inc. | 4,217 | $425.9K | 0.00% | −1,326−23.9% | Reduced |
| Xponance, Inc. | 4,162 | $420.3K | 0.00% | −110−2.6% | Reduced |
| LPL Financial LLC | 3,990 | $402.9K | 0.00% | −815−17.0% | Reduced |
| Gsa Capital Partners LLP | 3,897 | $394.0K | 0.03% | −2,200−36.1% | Reduced |
| Freestone Capital Holdings, LLC | 3,700 | $373.7K | 0.01% | 00.0% | Unchanged |
| FORA Capital, LLC | 3,599 | $363.5K | 0.06% | +3,599 | New |
| Mariner, LLC | 3,597 | $363.3K | 0.00% | −724−16.8% | Reduced |
| D. E. Shaw & Co., Inc. | 3,585 | $362.0K | 0.00% | −20,693−85.2% | Reduced |
| Nelson, Van Denburg & Campbell Wealth Management Group, LLC | 3,541 | $357.6K | 0.01% | −2,094−37.2% | Reduced |
| Capstone Investment Advisors, LLC | 3,497 | $353.2K | 0.00% | +3,497 | New |
| Two Sigma Advisers, LP | 3,300 | $333.3K | 0.00% | −6,400−66.0% | Reduced |
| JGP Global Gestao de Recursos Ltda. | 3,253 | $328.5K | 0.19% | −571−14.9% | Reduced |
| Susquehanna International Group, LLP | 3,104 | $313.5K | 0.00% | −74,158−96.0% | Reduced |
| Cim Investment Mangement Inc | 2,993 | $302.3K | 0.08% | +2,993 | New |
| Jane Street Group, LLC | 2,968 | $299.7K | 0.00% | +2,968 | New |
| Cerity Partners LLC | 2,964 | $299.3K | 0.00% | +2,964 | New |
| CWM, LLC | 2,892 | $292.0K | 0.00% | −199−6.4% | Reduced |
| Chicago Partners Investment Group LLC | 2,455 | $278.5K | 0.01% | −660−21.2% | Reduced |