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Praxis Precision Medicines, Inc.

PRAX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001689548

No open-market purchases or sales by Praxis Precision Medicines, Inc. insiders were filed in the last 90 days; 309 institutions reported holding it in 13F filings for Q2 2026, worth $11.3B in total; no superinvestor holds it.

13F holders, Q4 2025

Institutional positions in Praxis Precision Medicines, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
250
+100 vs. Q3 2025
Shares held
29.5M
+4.80M (+19.5%) vs. Q3 2025
Total value
$8.69B
+$7.38B (+564.4%) vs. Q3 2025
New holders
115
87 more added
Sold out
15
44 more reduced

2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PRAX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2025: 250 institutions
Q1 2021: 68 institutionsQ2 2021: 80 institutionsQ3 2021: 93 institutionsQ4 2021: 100 institutionsQ1 2022: 103 institutionsQ2 2022: 95 institutionsQ3 2022: 108 institutionsQ4 2022: 104 institutionsQ1 2023: 87 institutionsQ2 2023: 78 institutionsQ3 2023: 74 institutionsQ4 2023: 60 institutionsQ1 2024: 111 institutionsQ2 2024: 113 institutionsQ3 2024: 134 institutionsQ4 2024: 162 institutionsQ1 2025: 150 institutionsQ2 2025: 144 institutionsQ3 2025: 152 institutionsQ4 2025: 250 institutionsQ1 2026: 291 institutionsQ2 2026: 309 institutions
Value heldQ4 2025: $8.69B
Q1 2021: $1.19BQ2 2021: $751.0MQ3 2021: $791.5MQ4 2021: $863.1MQ1 2022: $463.4MQ2 2022: $105.5MQ3 2022: $95.7MQ4 2022: $108.1MQ1 2023: $43.1MQ2 2023: $134.6MQ3 2023: $195.6MQ4 2023: $178.6MQ1 2024: $971.3MQ2 2024: $762.1MQ3 2024: $1.09BQ4 2024: $1.67BQ1 2025: $889.3MQ2 2025: $1.02BQ3 2025: $1.31BQ4 2025: $8.69BQ1 2026: $10.2BQ2 2026: $11.3B
Institutions holding PRAX and their total value by quarter
QuarterHoldersValue
Q2 2026309$11.3B
Q1 2026291$10.2B
Q4 2025250$8.69B
Q3 2025152$1.31B
Q2 2025144$1.02B
Q1 2025150$889.3M
Q4 2024162$1.67B
Q3 2024134$1.09B
Q2 2024113$762.1M
Q1 2024111$971.3M
Q4 202360$178.6M
Q3 202374$195.6M
Q2 202378$134.6M
Q1 202387$43.1M
Q4 2022104$108.1M
Q3 2022108$95.7M
Q2 202295$105.5M
Q1 2022103$463.4M
Q4 2021100$863.1M
Q3 202193$791.5M
Q2 202180$751.0M
Q1 202168$1.19B

Institutions, Q4 2025

Shares, value and share of portfolio for each institution holding Praxis Precision Medicines, Inc.; share changes are against Q3 2025.

Institutions holding PRAX in Q4 2025
InstitutionSharesValue% of portfolioChange in sharesAction
Amalgamated Bank708$209.0K0.00%+109+18.2%Added
ACT Capital Management, LLC700$206.3K0.17%+700New
Sanctuary Advisors, LLC681$200.7K0.00%+681New
KBC Group NV676$199.0K0.00%+676New
Acadian Asset Management LLC629$184.0K0.00%+629New
Tower Research Capital LLC (TRC)611$180.1K0.00%−1,516−71.3%Reduced
Global Retirement Partners, LLC600$176.8K0.00%+600New
GF Fund Management Co. Ltd.490$144.4K0.00%+37+8.2%Added
Los Angeles Capital Management LLC552$111.0K0.00%+552New
Farther Finance Advisors, LLC368$108.5K0.00%+138+60.0%Added
BNP PARIBAS ASSET MANAGEMENT Holding S.A.279$82.0K0.00%+116+71.2%Added
GAMMA Investing LLC238$70.1K0.00%+88+58.7%Added
Danske Bank A/S200$58.9K0.00%+200New
NBC Securities, Inc.130$38.3K0.00%+130New
Zurcher Kantonalbank (Zurich Cantonalbank)98$28.9K0.00%00.0%Unchanged
Larson Financial Group LLC90$26.5K0.00%+19+26.8%Added
Advisor Group Holdings, Inc.83$24.5K0.00%+3+3.8%Added
Smartleaf Asset Management LLC74$22.0K0.00%+74New
SBI Securities Co., Ltd.74$21.8K0.00%−9−10.8%Reduced
Havemeyer Place LP74$21.8K0.00%+74New
Daiwa Securities Group Inc.72$21.0K0.00%+10+16.1%Added
Activest Wealth Management68$20.0K0.00%+68New
SRS Capital Advisors, Inc.64$18.9K0.00%−88−57.9%Reduced
Rockefeller Capital Management L.P.64$18.9K0.00%+62+3,100.0%Added
Kemnay Advisory Services Inc.61$18.0K0.00%+61New
Optiver Holding B.V.60$17.7K0.00%−80−57.1%Reduced
Rothschild Investment LLC50$14.7K0.00%+5+11.1%Added
Accent Capital Management, LLC50$14.7K0.01%+50New
Aspect Partners, LLC47$13.9K0.01%+47New
Federated Hermes, Inc.44$13.0K0.00%+44New
Allworth Financial LP28$8.25K0.00%+16+133.3%Added
EverSource Wealth Advisors, LLC25$7.37K0.00%+7+38.9%Added
J.Safra Asset Management Corp18$5.30K0.00%+18New
Comerica Bank17$5.19K0.00%+17New
CIBC Private Wealth Group, LLC17$5.01K0.00%+17New
Basecamp Wealth Advisors LLC16$4.72K0.00%+16New
Parkside Financial Bank & Trust14$4.13K0.00%+4+40.0%Added
ORG Partners LLC14$4.13K0.00%+14New
Bare Financial Services, Inc9$2.65K0.00%+9New
IFP Advisors, Inc6$1.77K0.00%+3+100.0%Added
Bellevue Asset Management, LLC6$1.77K0.00%+6New
Bell Investment Advisors, Inc5$1.47K0.00%+5New
MidFirst Bank5$1.47K0.00%+5New
Essential Partners LLC4$1.18K0.00%+3+300.0%Added
MAI Capital Management4$1.18K0.00%+4New
Parallel Advisors, LLC4$1.18K0.00%+4New
Covestor Ltd2$1.00K0.00%00.0%Unchanged
Marquette Asset Management, LLC2$5900.00%+2New
SJS Investment Consulting Inc.1$2950.00%+1New
Keating Financial Advisory Services, Inc.1$2950.00%+1New
5AM Venture Management, LLC0$00.00%−170,000−100.0%Sold out
Kennedy Capital Management, Inc.0$00.00%−76,218−100.0%Sold out
Tri Locum Partners LP0$00.00%−75,986−100.0%Sold out
Sphera Funds Management Ltd.0$00.00%−57,901−100.0%Sold out
Jane Street Group, LLC0$00.00%−31,687−100.0%Sold out
Knott David M Jr0$00.00%−28,000−100.0%Sold out
Simplex Trading, LLC0$00.00%−22,529−100.0%Sold out
Dark Forest Capital Management LP0$00.00%−21,684−100.0%Sold out
PCG Wealth Advisors, LLC0$00.00%−14,483−100.0%Sold out
Alps Advisors Inc0$00.00%−10,424−100.0%Sold out
Freestone Grove Partners LP0$00.00%−8,269−100.0%Sold out
Phoenix Holdings Ltd.0$00.00%−6,817−100.0%Sold out
Gsa Capital Partners LLP0$00.00%−5,740−100.0%Sold out
Jefferies Financial Group Inc.0$00.00%−2,000−100.0%Sold out
Clear Street Markets LLC0$00.00%−164−100.0%Sold out
FSA Wealth Management LLC––––Not filed
Hemington Wealth Management––––Not filed