Praxis Precision Medicines, Inc.
PRAX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001689548
No open-market purchases or sales by Praxis Precision Medicines, Inc. insiders were filed in the last 90 days; 309 institutions reported holding it in 13F filings for Q2 2026, worth $11.3B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Praxis Precision Medicines, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +100 vs. Q3 2025
- Shares held
- 29.5M
- +4.80M (+19.5%) vs. Q3 2025
- Total value
- $8.69B
- +$7.38B (+564.4%) vs. Q3 2025
- New holders
- 115
- 87 more added
- Sold out
- 15
- 44 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRAX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 309 | $11.3B |
| Q1 2026 | 291 | $10.2B |
| Q4 2025 | 250 | $8.69B |
| Q3 2025 | 152 | $1.31B |
| Q2 2025 | 144 | $1.02B |
| Q1 2025 | 150 | $889.3M |
| Q4 2024 | 162 | $1.67B |
| Q3 2024 | 134 | $1.09B |
| Q2 2024 | 113 | $762.1M |
| Q1 2024 | 111 | $971.3M |
| Q4 2023 | 60 | $178.6M |
| Q3 2023 | 74 | $195.6M |
| Q2 2023 | 78 | $134.6M |
| Q1 2023 | 87 | $43.1M |
| Q4 2022 | 104 | $108.1M |
| Q3 2022 | 108 | $95.7M |
| Q2 2022 | 95 | $105.5M |
| Q1 2022 | 103 | $463.4M |
| Q4 2021 | 100 | $863.1M |
| Q3 2021 | 93 | $791.5M |
| Q2 2021 | 80 | $751.0M |
| Q1 2021 | 68 | $1.19B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Praxis Precision Medicines, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Public Sector Pension Investment Board | 3,297 | $971.8K | 0.00% | +3,297 | New |
| Massachusetts Financial Services Co | 3,316 | $977.4K | 0.00% | +3,316 | New |
| Royal Bank of Canada | 3,378 | $995.0K | 0.00% | −578−14.6% | Reduced |
| Virginia Retirement Systems Et Al | 3,500 | $1.03M | 0.01% | −400−10.3% | Reduced |
| Walleye Capital LLC | 3,587 | $1.06M | 0.01% | +3,587 | New |
| Cerity Partners LLC | 3,927 | $1.16M | 0.00% | −1,523−27.9% | Reduced |
| Quarry LP | 4,000 | $1.18M | 0.19% | −16,001−80.0% | Reduced |
| Coastal Bridge Advisors, LLC | 4,154 | $1.22M | 0.09% | +308+8.0% | Added |
| Norges Bank | 4,354 | $1.28M | 0.00% | +4,354 | New |
| KLP Kapitalforvaltning AS | 4,400 | $1.30M | 0.01% | +400+10.0% | Added |
| Lion Point Capital, LP | 4,450 | $1.31M | 6.79% | −1,250−21.9% | Reduced |
| Vestmark Advisory Solutions, Inc. | 4,505 | $1.33M | 0.02% | +4,505 | New |
| Healthcare of Ontario Pension Plan Trust Fund | 4,587 | $1.35M | 0.00% | +4,587 | New |
| BNP Paribas Arbitrage, SA | 4,626 | $1.36M | 0.00% | +241+5.5% | Added |
| China Universal Asset Management Co., Ltd. | 4,875 | $1.44M | 0.11% | +1,186+32.1% | Added |
| ProShare Advisors LLC | 5,214 | $1.54M | 0.00% | +1,388+36.3% | Added |
| Raymond James Financial Inc | 5,235 | $1.54M | 0.00% | +5,235 | New |
| Group One Trading, L.P. | 5,539 | $1.63M | 0.05% | −11,089−66.7% | Reduced |
| Envestnet Asset Management Inc | 5,550 | $1.64M | 0.00% | +5,550 | New |
| J. Goldman & Co LP | 5,550 | $1.64M | 0.06% | +5,550 | New |
| Citigroup Inc | 5,586 | $1.65M | 0.00% | +2,779+99.0% | Added |
| Arizona State Retirement System | 5,723 | $1.69M | 0.01% | +306+5.6% | Added |
| State Board of Administration of Florida Retirement System | 5,806 | $1.71M | 0.00% | −619−9.6% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 6,057 | $1.79M | 0.01% | +1,142+23.2% | Added |
| Glenmede Trust Co NA | 6,288 | $1.85M | 0.01% | +6,288 | New |
| Connor, Clark & Lunn Investment Management Ltd. | 6,870 | $2.02M | 0.01% | +6,870 | New |
| State of New Jersey Common Pension Fund D | 7,018 | $2.07M | 0.01% | +7,018 | New |
| New York State Common Retirement Fund | 7,300 | $2.15M | 0.00% | +700+10.6% | Added |
| Nisa Investment Advisors, LLC | 7,770 | $2.29M | 0.01% | +641+9.0% | Added |
| Trexquant Investment LP | 8,331 | $2.46M | 0.02% | −574−6.4% | Reduced |
| Hussman Strategic Advisors, Inc. | 8,400 | $2.48M | 0.60% | −2,100−20.0% | Reduced |
| Profund Advisors LLC | 8,455 | $2.49M | 0.08% | +376+4.7% | Added |
| Intech Investment Management LLC | 8,734 | $2.57M | 0.02% | +980+12.6% | Added |
| SG Americas Securities, LLC | 9,965 | $2.94M | 0.00% | −3,531−26.2% | Reduced |
| Jacobs Levy Equity Management, Inc | 10,140 | $2.99M | 0.01% | −3,758−27.0% | Reduced |
| Creative Planning | 10,843 | $3.20M | 0.00% | +4,183+62.8% | Added |
| Erste Asset Management GmbH | 10,500 | $3.20M | 0.03% | +10,500 | New |
| MetLife Investment Management | 12,424 | $3.66M | 0.02% | +1,904+18.1% | Added |
| Victory Capital Management Inc | 13,298 | $3.92M | 0.00% | +13,298 | New |
| Voya Investment Management LLC | 13,655 | $4.02M | 0.00% | +13,655 | New |
| Prudential Financial Inc | 14,862 | $4.38M | 0.01% | +14,862 | New |
| Eagle Health Investments LP | 14,951 | $4.41M | 0.97% | +14,951 | New |
| State of Wisconsin Investment Board | 15,231 | $4.49M | 0.01% | +6,198+68.6% | Added |
| SEI Investments Co | 15,796 | $4.66M | 0.00% | +15,796 | New |
| Tudor Investment Corp Et Al | 16,009 | $4.72M | 0.03% | +16,009 | New |
| Prelude Capital Management, LLC | 16,038 | $4.73M | 0.35% | −12,064−42.9% | Reduced |
| Atom Investors LP | 16,487 | $4.86M | 0.39% | +16,487 | New |
| Legal & General Group Plc | 17,981 | $5.30M | 0.00% | +1,157+6.9% | Added |
| California State Teachers Retirement System | 19,671 | $5.80M | 0.01% | +1,088+5.9% | Added |
| Ally Bridge Group (NY) LLC | 19,882 | $5.86M | 9.30% | +19,882 | New |
| Russell Investments Group, Ltd. | 20,612 | $6.08M | 0.01% | +16,208+368.0% | Added |
| EAM Investors, LLC | 20,941 | $6.17M | 0.69% | +20,941 | New |
| Boothbay Fund Management, LLC | 20,974 | $6.18M | 0.16% | −18,686−47.1% | Reduced |
| StemPoint Capital LP | 21,067 | $6.21M | 1.07% | +21,067 | New |
| Man Group plc | 21,170 | $6.24M | 0.01% | +21,170 | New |
| Rafferty Asset Management, LLC | 22,240 | $6.56M | 0.02% | −15,333−40.8% | Reduced |
| Ameriprise Financial Inc | 22,715 | $6.70M | 0.00% | +22,715 | New |
| Polygon Management Ltd. | 22,952 | $6.76M | 1.43% | +22,952 | New |
| Two Sigma Investments, LP | 23,098 | $6.81M | 0.01% | +17,590+319.4% | Added |
| Susquehanna Portfolio Strategies, LLC | 23,251 | $6.85M | 0.11% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 23,543 | $6.94M | 0.00% | −13,871−37.1% | Reduced |
| Burkehill Global Management, LP | 25,000 | $7.37M | 0.49% | +25,000 | New |
| Alliancebernstein L.P. | 25,070 | $7.39M | 0.00% | +7,010+38.8% | Added |
| Wells Fargo & Company | 25,235 | $7.44M | 0.00% | +11,630+85.5% | Added |
| Mirae Asset Global ETFs Holdings Ltd. | 25,559 | $7.54M | 0.01% | +2,723+11.9% | Added |
| Neuberger Berman Group LLC | 25,678 | $7.57M | 0.01% | +25,678 | New |
| HighVista Strategies LLC | 25,841 | $7.62M | 1.96% | −69,161−72.8% | Reduced |
| Rhumbline Advisers | 28,324 | $8.35M | 0.01% | +1,530+5.7% | Added |
| AQR Capital Management LLC | 28,828 | $8.50M | 0.00% | +6,924+31.6% | Added |
| ArrowMark Colorado Holdings LLC | 30,000 | $8.84M | 0.19% | +30,000 | New |
| Lord, Abbett & Co. LLC | 30,756 | $9.06M | 0.03% | +30,756 | New |
| PFM Health Sciences, LP | 31,163 | $9.18M | 0.93% | −29,415−48.6% | Reduced |
| Congress Asset Management Co | 31,246 | $9.21M | 0.06% | +807+2.7% | Added |
| B Group, Inc. | 33,237 | $9.80M | 7.26% | +1,737+5.5% | Added |
| Caption Management, LLC | 33,300 | $9.81M | 0.43% | +26,943+423.8% | Added |
| Manufacturers Life Insurance Company, The | 33,291 | $9.86M | 0.01% | −2,538−7.1% | Reduced |
| Citadel Advisors LLC | 34,917 | $10.3M | 0.01% | +27,119+347.8% | Added |
| UBS Asset Management Americas Inc | 35,288 | $10.4M | 0.00% | +11,532+48.5% | Added |
| First Turn Management, LLC | 35,749 | $10.5M | 1.20% | +35,749 | New |
| Readystate Asset Management LP | 36,792 | $10.8M | 0.48% | −72,385−66.3% | Reduced |
| Empowered Funds, LLC | 36,852 | $10.9M | 0.18% | +36,852 | New |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 37,377 | $11.0M | 0.02% | +37,377 | New |
| D. E. Shaw & Co., Inc. | 37,481 | $11.0M | 0.01% | +17,685+89.3% | Added |
| Integral Health Asset Management, LLC | 40,000 | $11.8M | 0.60% | +40,000 | New |
| Ishara Investments LP | 40,000 | $11.8M | 13.72% | +40,000 | New |
| Swiss National Bank | 40,500 | $11.9M | 0.01% | +5,000+14.1% | Added |
| SummitTX Capital, L.P. | 41,629 | $12.3M | 0.37% | +6,701+19.2% | Added |
| Moody Aldrich Partners LLC | 41,731 | $12.3M | 2.30% | +41,731 | New |
| KVP Capital Advisors, LP | 42,900 | $12.6M | 13.06% | +42,900 | New |
| TD Asset Management Inc | 46,146 | $13.6M | 0.01% | +5,262+12.9% | Added |
| Boxer Capital Management, LLC | 46,457 | $13.7M | 3.00% | +46,457 | New |
| Nuveen, LLC | 49,970 | $14.7M | 0.00% | +11,421+29.6% | Added |
| Deutsche Bank AG | 50,811 | $15.0M | 0.00% | +36,955+266.7% | Added |
| JPMorgan Chase & Co | 55,300 | $16.3M | 0.00% | +29,092+111.0% | Added |
| Exome Asset Management LLC | 58,122 | $17.1M | 8.46% | −43,874−43.0% | Reduced |
| Ensign Peak Advisors, Inc | 64,283 | $18.9M | 0.03% | +64,283 | New |
| 72 Investment Holdings, LLC | 65,933 | $19.4M | 38.42% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 66,230 | $19.5M | 0.03% | +66,230 | New |
| Eventide Asset Management, LLC | 67,100 | $19.8M | 0.31% | +67,100 | New |
| Marshall Wace, LLP | 69,242 | $20.4M | 0.02% | +1,101+1.6% | Added |