Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q3 2025
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Sep 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 124
- +2 vs. Q2 2025
- Shares held
- 255.1M
- −1.13M (−0.4%) vs. Q2 2025
- Total value
- $344.4M
- +$101.5M (+41.8%) vs. Q2 2025
- New holders
- 19
- 26 more added
- Sold out
- 17
- 42 more reduced
1 institution that held it in Q2 2025 haven't filed for Q3 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q3 2025
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q2 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| UBS Group AG | 352,922 | $476.4K | 0.00% | −47,810−11.9% | Reduced |
| Northern Trust Corp | 369,794 | $499.2K | 0.00% | −46,578−11.2% | Reduced |
| Compagnie Lombard Odier SCmA | 410,000 | $553.5K | 0.01% | +80,000+24.2% | Added |
| Jane Street Group, LLC | 456,530 | $616.3K | 0.00% | −348,137−43.3% | Reduced |
| Invesco Ltd. | 521,403 | $703.9K | 0.00% | +100,703+23.9% | Added |
| Two Sigma Investments, LP | 559,008 | $754.7K | 0.00% | +155,086+38.4% | Added |
| Jacobs Levy Equity Management, Inc | 692,727 | $935.2K | 0.00% | +692,727 | New |
| Royal Bank of Canada | 722,435 | $975.0K | 0.00% | −52,039−6.7% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 779,212 | $1.05M | 0.04% | −14,188−1.8% | Reduced |
| Schonfeld Strategic Advisors LLC | 825,633 | $1.11M | 0.01% | −3,750,519−82.0% | Reduced |
| State Street Corp | 880,121 | $1.19M | 0.00% | +61,500+7.5% | Added |
| Susquehanna International Group, LLP | 962,060 | $1.30M | 0.00% | +206,408+27.3% | Added |
| Charles Schwab Investment Management Inc | 1,144,632 | $1.55M | 0.00% | +261,405+29.6% | Added |
| Gsa Capital Partners LLP | 1,202,906 | $1.62M | 0.14% | −1,627,753−57.5% | Reduced |
| Geode Capital Management, LLC | 2,397,923 | $3.24M | 0.00% | +20,229+0.9% | Added |
| CIBC Private Wealth Group, LLC | 2,400,257 | $3.24M | 0.01% | −50,143−2.0% | Reduced |
| Citadel Advisors LLC | 2,634,027 | $3.56M | 0.00% | +2,634,027 | New |
| Sessa Capital IM, L.P. | 3,000,000 | $4.05M | 0.10% | 00.0% | Unchanged |
| BlackRock, Inc. | 3,394,972 | $4.58M | 0.00% | +40,303+1.2% | Added |
| Millennium Management LLC | 3,830,660 | $5.17M | 0.00% | +2,187,396+133.1% | Added |
| Vanguard Group Inc | 9,521,874 | $12.9M | 0.00% | +670,838+7.6% | Added |
| FMR LLC | 38,679,748 | $52.2M | 0.00% | +542,213+1.4% | Added |
| Siren, L.L.C. | 38,918,903 | $52.5M | 2.06% | 00.0% | Unchanged |
| Artal Group S.A. | 136,180,481 | $183.8M | 24.25% | 00.0% | Unchanged |
| Wellington Management Group LLP | 0 | $0 | 0.00% | −486,674−100.0% | Sold out |
| Jain Global LLC | 0 | $0 | 0.00% | −151,813−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −146,805−100.0% | Sold out |
| Aster Capital Management (DIFC) Ltd | 0 | $0 | 0.00% | −130,452−100.0% | Sold out |
| Quantessence Capital LLC | 0 | $0 | 0.00% | −84,098−100.0% | Sold out |
| Pallas Capital Advisors LLC | 0 | $0 | 0.00% | −36,765−100.0% | Sold out |
| Hudson Bay Capital Management LP | 0 | $0 | 0.00% | −27,010−100.0% | Sold out |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −23,723−100.0% | Sold out |
| Merit Financial Group, LLC | 0 | $0 | 0.00% | −16,699−100.0% | Sold out |
| Integrated Wealth Concepts LLC | 0 | $0 | 0.00% | −16,210−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −15,993−100.0% | Sold out |
| HighTower Advisors, LLC | 0 | $0 | 0.00% | −14,910−100.0% | Sold out |
| Buckingham Strategic Partners | 0 | $0 | 0.00% | −13,746−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −12,241−100.0% | Sold out |
| Raymond James Financial Inc | 0 | $0 | 0.00% | −2,076−100.0% | Sold out |
| Quintet Private Bank (Europe) S.A. | 0 | $0 | 0.00% | −1,928−100.0% | Sold out |
| CBIZ Investment Advisory Services, LLC | 0 | $0 | 0.00% | −71−100.0% | Sold out |
| Avantax Advisory Services, Inc. | – | – | – | – | Not filed |