Amylyx Pharmaceuticals, Inc.
AMLX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001658551
In the last 90 days, Amylyx Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 206 institutions reported holding it in 13F filings for Q2 2026, worth $2.07B in total; no superinvestor holds it.
13F holders, Q1 2025
Institutional positions in Amylyx Pharmaceuticals, Inc. as of Mar 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 136
- +16 vs. Q4 2024
- Shares held
- 73.9M
- +24.1M (+48.4%) vs. Q4 2024
- Total value
- $261.6M
- +$73.3M (+39.0%) vs. Q4 2024
- New holders
- 32
- 50 more added
- Sold out
- 16
- 31 more reduced
2 institutions that held it in Q4 2024 haven't filed for Q1 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting AMLX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 206 | $2.07B |
| Q1 2026 | 171 | $1.59B |
| Q4 2025 | 180 | $1.36B |
| Q3 2025 | 169 | $1.49B |
| Q2 2025 | 131 | $523.6M |
| Q1 2025 | 136 | $261.6M |
| Q4 2024 | 122 | $188.3M |
| Q3 2024 | 110 | $140.8M |
| Q2 2024 | 119 | $82.9M |
| Q1 2024 | 143 | $141.5M |
| Q4 2023 | 178 | $887.4M |
| Q3 2023 | 170 | $1.08B |
| Q2 2023 | 154 | $1.18B |
| Q1 2023 | 147 | $1.51B |
| Q4 2022 | 133 | $1.79B |
| Q3 2022 | 95 | $1.05B |
| Q2 2022 | 78 | $512.9M |
| Q1 2022 | 72 | $299.9M |
| Q4 2021 | 0 | $0 |
| Q3 2021 | 0 | $0 |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q1 2025
Shares, value and share of portfolio for each institution holding Amylyx Pharmaceuticals, Inc.; share changes are against Q4 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Rock Springs Capital Management LP | 343,228 | $1.22M | 0.07% | +343,228 | New |
| OrbiMed Advisors LLC | 348,000 | $1.23M | 0.03% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 372,853 | $1.32M | 0.00% | +73,904+24.7% | Added |
| Citigroup Inc | 463,240 | $1.64M | 0.00% | −146,084−24.0% | Reduced |
| Morgan Stanley | 474,418 | $1.68M | 0.00% | +10,198+2.2% | Added |
| Renaissance Technologies LLC | 515,100 | $1.82M | 0.00% | +50,700+10.9% | Added |
| Deutsche Bank AG | 570,857 | $2.02M | 0.00% | 00.0% | Unchanged |
| Two Sigma Advisers, LP | 649,800 | $2.30M | 0.01% | +408,400+169.2% | Added |
| Alyeska Investment Group, L.P. | 750,412 | $2.66M | 0.01% | −73,008−8.9% | Reduced |
| Two Sigma Investments, LP | 762,053 | $2.70M | 0.01% | +110,536+17.0% | Added |
| Bank of America Corp | 794,354 | $2.81M | 0.00% | −1,631,909−67.3% | Reduced |
| Geode Capital Management, LLC | 806,161 | $2.85M | 0.00% | +238,258+42.0% | Added |
| PFM Health Sciences, LP | 834,135 | $2.95M | 0.23% | +834,135 | New |
| Point72 Asset Management, L.P. | 916,966 | $3.25M | 0.01% | +916,966 | New |
| Qube Research & Technologies Ltd | 942,891 | $3.34M | 0.01% | +162,325+20.8% | Added |
| FMR LLC | 1,157,988 | $4.10M | 0.00% | +426,632+58.3% | Added |
| Connor, Clark & Lunn Investment Management Ltd. | 1,199,691 | $4.25M | 0.02% | −63,662−5.0% | Reduced |
| UBS Group AG | 1,388,427 | $4.92M | 0.00% | +744,903+115.8% | Added |
| Susquehanna International Group, LLP | 1,470,925 | $5.21M | 0.01% | +602,543+69.4% | Added |
| ADAR1 Capital Management, LLC | 1,471,587 | $5.21M | 1.00% | +1,471,587 | New |
| Woodline Partners LP | 1,609,447 | $5.70M | 0.04% | +1,609,447 | New |
| Boxer Capital Management, LLC | 1,750,000 | $6.20M | 1.86% | 00.0% | Unchanged |
| Great Point Partners LLC | 1,811,996 | $6.41M | 3.49% | +1,811,996 | New |
| Goldman Sachs Group Inc | 2,002,961 | $7.09M | 0.00% | +143,065+7.7% | Added |
| Almitas Capital LLC | 2,122,597 | $7.51M | 2.49% | +90,227+4.4% | Added |
| BlackRock, Inc. | 2,387,409 | $8.45M | 0.00% | +108,475+4.8% | Added |
| 683 Capital Management, LLC | 2,411,400 | $8.54M | 0.87% | +481,400+24.9% | Added |
| Saturn V Capital Management LLC | 2,426,436 | $8.59M | 4.33% | +1,537,363+172.9% | Added |
| Standard Life Aberdeen plc | 2,430,358 | $8.60M | 0.02% | +707,553+41.1% | Added |
| Citadel Advisors LLC | 2,757,776 | $9.76M | 0.01% | +787,072+39.9% | Added |
| Nantahala Capital Management, LLC | 2,934,405 | $10.4M | 0.86% | +1,482,252+102.1% | Added |
| Millennium Management LLC | 3,081,853 | $10.9M | 0.01% | +2,487,617+418.6% | Added |
| Vanguard Group Inc | 4,116,512 | $14.6M | 0.00% | +1,424,023+52.9% | Added |
| Adage Capital Partners GP, L.L.C. | 5,697,605 | $20.2M | 0.04% | +5,697,605 | New |
| TCG Crossover Management, LLC | 5,943,812 | $21.0M | 2.87% | +1,300,000+28.0% | Added |
| Perceptive Advisors LLC | 7,874,348 | $27.9M | 0.99% | +1,100,000+16.2% | Added |
| Ikarian Capital, LLC | 0 | $0 | 0.00% | −201,187−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −188,386−100.0% | Sold out |
| Mackenzie Financial Corp | 0 | $0 | 0.00% | −111,310−100.0% | Sold out |
| Jump Financial, LLC | 0 | $0 | 0.00% | −104,342−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −80,543−100.0% | Sold out |
| Landscape Capital Management, L.L.C. | 0 | $0 | 0.00% | −49,661−100.0% | Sold out |
| Wedbush Securities Inc | 0 | $0 | 0.00% | −19,914−100.0% | Sold out |
| Y-Intercept (Hong Kong) Ltd | 0 | $0 | 0.00% | −14,809−100.0% | Sold out |
| Rpo LLC | 0 | $0 | 0.00% | −12,136−100.0% | Sold out |
| Alpine Global Management, LLC | 0 | $0 | 0.00% | −12,017−100.0% | Sold out |
| Bank of Nova Scotia | 0 | $0 | 0.00% | −11,884−100.0% | Sold out |
| Fox Run Management, L.L.C. | 0 | $0 | 0.00% | −11,788−100.0% | Sold out |
| Vident Advisory, LLC | 0 | $0 | 0.00% | −10,862−100.0% | Sold out |
| Walleye Trading LLC | 0 | $0 | 0.00% | −2,649−100.0% | Sold out |
| SRS Capital Advisors, Inc. | 0 | $0 | 0.00% | −2,193−100.0% | Sold out |
| Advisor Group Holdings, Inc. | 0 | $0 | 0.00% | −638−100.0% | Sold out |
| Oliver Lagore Vanvalin Investment Group | – | – | – | – | Not filed |
| Global Retirement Partners, LLC | – | – | – | – | Not filed |