Tyra Biosciences, Inc.
TYRA- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001863127
In the last 90 days, Tyra Biosciences, Inc. insiders filed 1 open-market purchase and 0 sales; 168 institutions reported holding it in 13F filings for Q2 2026, worth $2.22B in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Tyra Biosciences, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 168
- +6 vs. Q1 2026
- Shares held
- 69.3M
- +7.29M (+11.7%) vs. Q1 2026
- Total value
- $2.22B
- −$160.6M (−6.8%) vs. Q1 2026
- New holders
- 32
- 73 more added
- Sold out
- 26
- 44 more reduced
2 institutions that held it in Q1 2026 haven't filed for Q2 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting TYRA on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 168 | $2.22B |
| Q1 2026 | 164 | $2.52B |
| Q4 2025 | 133 | $1.49B |
| Q3 2025 | 116 | $778.4M |
| Q2 2025 | 121 | $541.5M |
| Q1 2025 | 117 | $499.5M |
| Q4 2024 | 113 | $675.8M |
| Q3 2024 | 95 | $1.11B |
| Q2 2024 | 79 | $748.6M |
| Q1 2024 | 77 | $768.4M |
| Q4 2023 | 62 | $495.2M |
| Q3 2023 | 59 | $502.1M |
| Q2 2023 | 59 | $616.7M |
| Q1 2023 | 51 | $573.0M |
| Q4 2022 | 46 | $267.8M |
| Q3 2022 | 49 | $313.8M |
| Q2 2022 | 48 | $255.6M |
| Q1 2022 | 46 | $386.6M |
| Q4 2021 | 45 | $494.2M |
| Q3 2021 | 26 | $456.8M |
| Q2 2021 | 0 | $0 |
| Q1 2021 | 0 | $0 |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Tyra Biosciences, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Alps Advisors Inc | 60,159 | $1.92M | 0.01% | +16,303+37.2% | Added |
| Fisher Asset Management, LLC | 60,230 | $1.92M | 0.00% | +31,430+109.1% | Added |
| Citigroup Inc | 62,279 | $1.99M | 0.00% | +56,288+939.5% | Added |
| Squarepoint Ops LLC | 63,805 | $2.04M | 0.00% | +43,311+211.3% | Added |
| SEI Investments Co | 66,607 | $2.13M | 0.00% | +66,607 | New |
| Kalehua Capital Management LLC | 74,465 | $2.38M | 1.37% | 00.0% | Unchanged |
| Nuveen, LLC | 78,829 | $2.52M | 0.00% | +27,989+55.1% | Added |
| XTX Topco Ltd | 81,320 | $2.60M | 0.03% | −2,576−3.1% | Reduced |
| Oppenheimer & Co Inc | 83,783 | $2.68M | 0.03% | −409−0.5% | Reduced |
| Jacobs Levy Equity Management, Inc | 89,205 | $2.85M | 0.01% | −72,999−45.0% | Reduced |
| OrbiMed Advisors LLC | 102,000 | $3.26M | 0.06% | +102,000 | New |
| Russell Investments Group, Ltd. | 102,703 | $3.28M | 0.00% | +32,281+45.8% | Added |
| Bank of New York Mellon Corp | 103,720 | $3.31M | 0.00% | +31,507+43.6% | Added |
| Lord, Abbett & Co. LLC | 121,833 | $3.89M | 0.01% | +121,833 | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 123,420 | $3.94M | 0.00% | −5,440−4.2% | Reduced |
| UBS Group AG | 129,945 | $4.15M | 0.00% | +68,384+111.1% | Added |
| Trexquant Investment LP | 132,740 | $4.24M | 0.03% | −14,577−9.9% | Reduced |
| Ensign Peak Advisors, Inc | 146,537 | $4.68M | 0.01% | +72,473+97.9% | Added |
| Victory Capital Management Inc | 152,585 | $4.87M | 0.00% | +137,355+901.9% | Added |
| Jump Financial, LLC | 157,000 | $5.01M | 0.04% | +115,625+279.5% | Added |
| Adage Capital Partners GP, L.L.C. | 162,000 | $5.17M | 0.01% | +162,000 | New |
| Boothbay Fund Management, LLC | 173,559 | $5.54M | 0.11% | −99,715−36.5% | Reduced |
| Millennium Management LLC | 177,672 | $5.67M | 0.00% | −43,909−19.8% | Reduced |
| JPMorgan Chase & Co | 178,263 | $5.74M | 0.00% | +111,474+166.9% | Added |
| Raymond James Financial Inc | 180,881 | $5.78M | 0.00% | −66,217−26.8% | Reduced |
| HighVista Strategies LLC | 184,774 | $5.90M | 1.35% | +53,470+40.7% | Added |
| Franklin Resources Inc | 192,340 | $6.14M | 0.00% | +179,370+1,383.0% | Added |
| Affinity Asset Advisors, LLC | 200,012 | $6.39M | 0.31% | −57,500−22.3% | Reduced |
| Dimensional Fund Advisors LP | 217,078 | $6.93M | 0.00% | +125,252+136.4% | Added |
| Vanguard Fiduciary Trust Co | 224,805 | $7.18M | 0.00% | +67,014+42.5% | Added |
| Algert Global LLC | 239,120 | $7.64M | 0.09% | +51,110+27.2% | Added |
| BNP Paribas Arbitrage, SA | 240,227 | $7.67M | 0.00% | +50,188+26.4% | Added |
| Qube Research & Technologies Ltd | 266,934 | $8.53M | 0.01% | +266,934 | New |
| Charles Schwab Investment Management Inc | 267,699 | $8.55M | 0.00% | +68,588+34.4% | Added |
| Citadel Advisors LLC | 278,307 | $8.89M | 0.01% | +262,911+1,707.7% | Added |
| Morgan Stanley | 300,322 | $9.59M | 0.00% | +179,837+149.3% | Added |
| Northern Trust Corp | 310,084 | $9.90M | 0.00% | +91,576+41.9% | Added |
| Woodline Partners LP | 320,040 | $10.2M | 0.03% | +19,000+6.3% | Added |
| Walleye Capital LLC | 347,898 | $11.1M | 0.05% | +329,183+1,758.9% | Added |
| Bank of America Corp | 349,732 | $11.2M | 0.00% | +139,810+66.6% | Added |
| Defilade Capital Management, L.P. | 376,870 | $12.0M | 1.61% | +376,870 | New |
| Vanguard Portfolio Management LLC | 403,019 | $12.9M | 0.00% | +155,749+63.0% | Added |
| Two Sigma Investments, LP | 449,808 | $14.4M | 0.01% | +348,190+342.6% | Added |
| Jennison Associates LLC | 450,964 | $14.4M | 0.01% | −181,468−28.7% | Reduced |
| Goldman Sachs Group Inc | 463,477 | $14.8M | 0.00% | −86,857−15.8% | Reduced |
| Marshall Wace, LLP | 583,133 | $18.6M | 0.02% | +385,385+194.9% | Added |
| StemPoint Capital LP | 632,754 | $20.2M | 3.50% | +439,577+227.6% | Added |
| Sio Capital Management, LLC | 695,315 | $22.2M | 3.81% | +89,876+14.8% | Added |
| Siren, L.L.C. | 725,000 | $23.2M | 0.47% | +725,000 | New |
| Canaan Partners XI LLC | 750,000 | $24.0M | 18.82% | 00.0% | Unchanged |
| Caligan Partners LP | 806,986 | $25.8M | 1.24% | −469,982−36.8% | Reduced |
| Geode Capital Management, LLC | 970,734 | $31.0M | 0.00% | +312,252+47.4% | Added |
| Hood River Capital Management LLC | 1,016,775 | $32.5M | 0.24% | +1,016,775 | New |
| Deerfield Management Company, L.P. (Series C) | 1,017,000 | $32.5M | 0.34% | +468,000+85.2% | Added |
| 5AM Venture Management, LLC | 1,029,298 | $32.9M | 11.42% | 00.0% | Unchanged |
| BVF Inc | 1,476,196 | $47.1M | 1.21% | −500,000−25.3% | Reduced |
| Vanguard Capital Management LLC | 1,508,447 | $48.2M | 0.00% | +382,477+34.0% | Added |
| Paradigm Biocapital Advisors LP | 1,828,607 | $58.4M | 1.09% | −226,384−11.0% | Reduced |
| Commodore Capital LP | 1,875,000 | $59.9M | 3.57% | −600,000−24.2% | Reduced |
| State Street Corp | 2,140,368 | $68.4M | 0.00% | +924,290+76.0% | Added |
| Price T Rowe Associates Inc | 2,782,567 | $88.9M | 0.01% | +1,796,506+182.2% | Added |
| BlackRock, Inc. | 3,031,972 | $96.8M | 0.00% | +814,043+36.7% | Added |
| TCG Crossover Management, LLC | 3,248,980 | $103.8M | 2.49% | 00.0% | Unchanged |
| Nextech Invest, Ltd. | 3,553,585 | $113.5M | 5.39% | −502,276−12.4% | Reduced |
| Alta Partners Management Company, L.P. | 3,823,425 | $122.1M | 95.92% | 00.0% | Unchanged |
| Jupiter Topco LLC | 4,352,448 | $139.2M | 0.06% | +4,352,448 | New |
| FMR LLC | 8,920,513 | $284.9M | 0.01% | +1,172,865+15.1% | Added |
| Ra Capital Management, L.P. | 12,198,625 | $389.6M | 3.39% | 00.0% | Unchanged |
| Farallon Capital Management, L.L.C. | 0 | $0 | 0.00% | −3,580,818−100.0% | Sold out |
| Logos Global Management LP | 0 | $0 | 0.00% | −850,000−100.0% | Sold out |
| Balyasny Asset Management LLC | 0 | $0 | 0.00% | −351,479−100.0% | Sold out |
| Seven Fleet Capital Management LP | 0 | $0 | 0.00% | −198,585−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −79,592−100.0% | Sold out |
| Catalio Capital Management, LP | 0 | $0 | 0.00% | −67,285−100.0% | Sold out |
| Vestal Point Capital, LP | 0 | $0 | 0.00% | −54,000−100.0% | Sold out |
| American Century Companies Inc | 0 | $0 | 0.00% | −47,929−100.0% | Sold out |
| Point72 Asset Management, L.P. | 0 | $0 | 0.00% | −38,850−100.0% | Sold out |
| Brevan Howard Capital Management LP | 0 | $0 | 0.00% | −38,606−100.0% | Sold out |
| Eversept Partners, LP | 0 | $0 | 0.00% | −27,055−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −18,203−100.0% | Sold out |
| Tudor Investment Corp Et Al | 0 | $0 | 0.00% | −16,284−100.0% | Sold out |
| PSP Research LLC | 0 | $0 | 0.00% | −16,000−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −15,543−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −10,169−100.0% | Sold out |
| Soleus Capital Management, L.P. | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | $0 | 0.00% | −8,075−100.0% | Sold out |
| Bridgefront Capital, LLC | 0 | $0 | 0.00% | −7,911−100.0% | Sold out |
| Allianz Asset Management GmbH | 0 | $0 | 0.00% | −7,000−100.0% | Sold out |
| Graham Capital Management, L.P. | 0 | $0 | 0.00% | −5,756−100.0% | Sold out |
| Persistent Asset Partners Ltd | 0 | $0 | 0.00% | −4,518−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −243−100.0% | Sold out |
| US Bancorp | 0 | $0 | 0.00% | −11−100.0% | Sold out |
| Twin Peaks Wealth Advisors, LLC | 0 | $0 | 0.00% | −7−100.0% | Sold out |
| MAI Capital Management | 0 | $0 | 0.00% | −4−100.0% | Sold out |
| Janus Henderson Group PLC | – | – | – | – | Not filed |
| CWM, LLC | – | – | – | – | Not filed |