Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q4 2024
Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 50
- +4 vs. Q3 2024
- Shares held
- 15.7M
- +3.34M (+27.0%) vs. Q3 2024
- Total value
- $16.1M
- −$390.7K (−2.4%) vs. Q3 2024
- New holders
- 12
- 13 more added
- Sold out
- 8
- 9 more reduced
Compare with Q3 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q4 2024
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 3,839,886 | $3.96M | 0.49% | +89,436+2.4% | Added |
| Pfizer Inc | 2,362,348 | $2.43M | 0.09% | +2,362,348 | New |
| Vanguard Group Inc | 1,763,620 | $1.82M | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 1,105,591 | $1.14M | 0.00% | +130,938+13.4% | Added |
| Acadian Asset Management LLC | 1,039,922 | $1.07M | 0.00% | −31,938−3.0% | Reduced |
| Alphabet Inc. | 889,979 | $916.7K | 0.05% | 00.0% | Unchanged |
| Murchinson Ltd. | 873,910 | $900.1K | 0.40% | +873,910 | New |
| ADAR1 Capital Management, LLC | 801,277 | $825.3K | 0.17% | +57,818+7.8% | Added |
| BlackRock, Inc. | 485,352 | $499.9K | 0.00% | +532+0.1% | Added |
| Geode Capital Management, LLC | 481,128 | $495.7K | 0.00% | −590.0% | Reduced |
| Monimus Capital Management, LP | 310,908 | $320.2K | 0.30% | +310,908 | New |
| Atlas Venture Life Science Advisors, LLC | 305,255 | $314.4K | 0.04% | −97,630−24.2% | Reduced |
| Mackenzie Financial Corp | 187,559 | $193.2K | 0.00% | +155,656+487.9% | Added |
| Bridgeway Capital Management, LLC | 184,800 | $190.3K | 0.00% | 00.0% | Unchanged |
| Citadel Advisors LLC | 172,872 | $178.1K | 0.00% | +91,447+112.3% | Added |
| State Street Corp | 148,911 | $153.4K | 0.00% | +18,400+14.1% | Added |
| DAFNA Capital Management LLC | 125,000 | $128.8K | 0.03% | 00.0% | Unchanged |
| Northern Trust Corp | 86,447 | $89.0K | 0.00% | −25,050−22.5% | Reduced |
| JPMorgan Chase & Co | 61,624 | $63.5K | 0.00% | +61,388+26,011.9% | Added |
| Squarepoint Ops LLC | 55,051 | $56.7K | 0.00% | +55,051 | New |
| Jane Street Group, LLC | 52,869 | $54.5K | 0.00% | +52,869 | New |
| Prudential Financial Inc | 49,200 | $50.7K | 0.00% | +49,200 | New |
| Virtu Financial LLC | 46,046 | $47.0K | 0.00% | +46,046 | New |
| XTX Topco Ltd | 30,138 | $31.0K | 0.00% | +30,138 | New |
| Three Seasons Wealth, LLC | 30,000 | $30.9K | 0.02% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 29,755 | $30.6K | 0.00% | −14,464−32.7% | Reduced |
| DLK Investment Management, LLC | 28,955 | $29.8K | 0.01% | −2,400−7.7% | Reduced |
| Charles Schwab Investment Management Inc | 28,565 | $29.4K | 0.00% | 00.0% | Unchanged |
| PFG Investments, LLC | 24,534 | $25.3K | 0.00% | +10,555+75.5% | Added |
| HRT Financial LP | 14,692 | $15.0K | 0.00% | +14,692 | New |
| Dimensional Fund Advisors LP | 10,003 | $10.3K | 0.00% | 00.0% | Unchanged |
| National Bank of Canada | 10,000 | $10.3K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $10.3K | 0.00% | +10,000 | New |
| Morgan Stanley | 6,971 | $7.18K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 5,547 | $5.71K | 0.00% | −107−1.9% | Reduced |
| US Bancorp | 5,151 | $5.31K | 0.00% | +5,000+3,311.3% | Added |
| Simplex Trading, LLC | 5,110 | $5.00K | 0.00% | +4,189+454.8% | Added |
| FMR LLC | 4,289 | $4.42K | 0.00% | +1,150+36.6% | Added |
| WR Wealth Planners, LLC | 2,600 | $2.68K | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 2,000 | $2.06K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 929 | $957 | 0.00% | +660+245.4% | Added |
| Advisor Group Holdings, Inc. | 295 | $304 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 213 | $219 | 0.00% | +213 | New |
| Wells Fargo & Company | 200 | $206 | 0.00% | 00.0% | Unchanged |
| Richards, Merrill & Peterson, Inc. | 150 | $155 | 0.00% | +150 | New |
| UBS Group AG | 141 | $145 | 0.00% | −17,388−99.2% | Reduced |
| GWM Advisors LLC | 100 | $103 | 0.00% | 00.0% | Unchanged |
| CoreCap Advisors, LLC | 50 | $52 | 0.00% | −142−74.0% | Reduced |
| Federation des caisses Desjardins du Quebec | 30 | $31 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 12 | $12 | 0.00% | 00.0% | Unchanged |
| Novo Holdings A/S | 0 | $0 | 0.00% | −468,902−100.0% | Sold out |
| AWM Investment Company, Inc. | 0 | $0 | 0.00% | −333,400−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −38,481−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −32,172−100.0% | Sold out |
| Shay Capital LLC | 0 | $0 | 0.00% | −25,000−100.0% | Sold out |
| Russell Investments Group, Ltd. | 0 | $0 | 0.00% | −6,400−100.0% | Sold out |
| CIBC Private Wealth Group, LLC | 0 | $0 | 0.00% | −2,880−100.0% | Sold out |
| Northwestern Mutual Wealth Management Co | 0 | $0 | 0.00% | −50−100.0% | Sold out |