Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q3 2022
Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 69
- −10 vs. Q2 2022
- Shares held
- 19.9M
- −1.11M (−5.3%) vs. Q2 2022
- Total value
- $39.7M
- +$24.2M (+155.8%) vs. Q2 2022
- New holders
- 14
- 11 more added
- Sold out
- 24
- 20 more reduced
Compare with Q2 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q3 2022
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Aquilo Capital Management, LLC | 3,403,210 | $6.81M | 2.86% | −1,918,021−36.0% | Reduced |
| AWM Investment Company, Inc. | 2,300,400 | $4.60M | 0.70% | +2,300,400 | New |
| BVF Inc | 1,929,376 | $3.86M | 0.16% | −1,160,239−37.6% | Reduced |
| Anson Funds Management LP | 1,473,872 | $2.95M | 0.40% | +1,473,872 | New |
| Atlas Venture Associates IX, LLC | 1,376,968 | $2.75M | 8.16% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,053,723 | $2.11M | 0.00% | −192,269−15.4% | Reduced |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $2.06M | 0.23% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $1.78M | 0.09% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 770,710 | $1.54M | 0.04% | 00.0% | Unchanged |
| Murchinson Ltd. | 762,700 | $1.52M | 0.44% | +762,700 | New |
| BlackRock Inc. | 692,138 | $1.39M | 0.00% | +1,385+0.2% | Added |
| Millennium Management LLC | 688,396 | $1.38M | 0.00% | +373,753+118.8% | Added |
| Artal Group S.A. | 500,000 | $1.00M | 0.05% | 00.0% | Unchanged |
| Novo Holdings A/S | 468,902 | $938.0K | 0.04% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 290,258 | $580.0K | 0.00% | 00.0% | Unchanged |
| Oasis Management Co Ltd. | 288,000 | $576.0K | 0.10% | 00.0% | Unchanged |
| OUP Management Co., LLC | 249,070 | $498.0K | 0.78% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 214,700 | $429.0K | 0.00% | −724,317−77.1% | Reduced |
| Bank of Montreal | 202,300 | $415.0K | 0.00% | +202,300 | New |
| Marshall Wace, LLP | 186,570 | $374.0K | 0.00% | +150,201+413.0% | Added |
| AQR Capital Management LLC | 186,682 | $373.0K | 0.00% | +31,208+20.1% | Added |
| DAFNA Capital Management LLC | 125,000 | $250.0K | 0.07% | +125,000 | New |
| State Street Corp | 91,311 | $183.0K | 0.00% | −9,073−9.0% | Reduced |
| Letko, Brosseau & Associates Inc | 73,659 | $147.0K | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 69,963 | $140.0K | 0.00% | −50.0% | Reduced |
| Susquehanna International Group, LLP | 69,286 | $139.0K | 0.00% | +15,141+28.0% | Added |
| Acadian Asset Management LLC | 61,152 | $121.0K | 0.00% | −33,825−35.6% | Reduced |
| Goldman Sachs Group Inc | 55,438 | $111.0K | 0.00% | −247,763−81.7% | Reduced |
| Group One Trading, L.P. | 55,100 | $110.0K | 0.00% | +30,856+127.3% | Added |
| Advisor Group Holdings, Inc. | 24,817 | $50.0K | 0.00% | +22,022+787.9% | Added |
| UBS Group AG | 22,908 | $46.0K | 0.00% | +22,153+2,934.2% | Added |
| Bourgeon Capital Management LLC | 20,600 | $41.0K | 0.01% | +3,000+17.0% | Added |
| Morgan Stanley | 19,254 | $38.0K | 0.00% | −175,177−90.1% | Reduced |
| Williams Jones Wealth Management, LLC. | 19,000 | $38.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 18,239 | $37.0K | 0.00% | −6,838−27.3% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $35.0K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 16,423 | $33.0K | 0.00% | +16,423 | New |
| Qube Research & Technologies Ltd | 15,948 | $32.0K | 0.00% | −1,716−9.7% | Reduced |
| Jane Street Group, LLC | 15,496 | $31.0K | 0.00% | +15,496 | New |
| Weitzel Financial Services, Inc. | 14,200 | $28.4K | 0.02% | +14,200 | New |
| Stifel Financial Corp | 12,506 | $25.0K | 0.00% | −13,722−52.3% | Reduced |
| Sentinel Pension Advisors Inc | 12,000 | $24.0K | 0.01% | −30,000−71.4% | Reduced |
| LMR Partners LLP | 11,508 | $23.0K | 0.00% | 00.0% | Unchanged |
| Man Group plc | 11,184 | $22.0K | 0.00% | +11,184 | New |
| Dimensional Fund Advisors LP | 10,003 | $20.0K | 0.00% | −274,953−96.5% | Reduced |
| Bank of America Corp | 9,781 | $19.0K | 0.00% | −8,794−47.3% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $12.0K | 0.00% | 00.0% | Unchanged |
| Quantbot Technologies LP | 2,900 | $5.00K | 0.00% | +2,900 | New |
| Federated Hermes, Inc. | 1,952 | $4.00K | 0.00% | −627−24.3% | Reduced |
| Cullen/Frost Bankers, Inc. | 2,000 | $4.00K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,950 | $4.00K | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,588 | $3.00K | 0.00% | +313+24.5% | Added |
| Simplex Trading, LLC | 1,000 | $2.00K | 0.00% | −8,300−89.2% | Reduced |
| Atlas Capital Advisors LLC | 727 | $1.45K | 0.00% | +727 | New |
| BNP Paribas Arbitrage, SA | 522 | $1.04K | 0.00% | −26,654−98.1% | Reduced |
| Citigroup Inc | 495 | $1.00K | 0.00% | −13,867−96.6% | Reduced |
| TD Waterhouse Canada Inc. | 500 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 600 | $1.00K | 0.00% | +498+488.2% | Added |
| Beaird Harris Wealth Management, LLC | 282 | $1.00K | 0.00% | 00.0% | Unchanged |
| Crewe Advisors LLC | 258 | $1.00K | 0.00% | +258 | New |
| China Universal Asset Management Co., Ltd. | 329 | $1.00K | 0.00% | +329 | New |
| PFS Partners, LLC | 250 | $500 | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $374 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 403 | $0 | 0.00% | −488−54.8% | Reduced |
| US Bancorp | 151 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $0 | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $0 | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $0 | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 43 | $0 | 0.00% | +43 | New |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −649,334−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −437,280−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −176,157−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −131,020−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −108,351−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −102,408−100.0% | Sold out |
| Knoll Capital Management, LLC | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Kingsbury Capital Investment Advisors LLC | 0 | $0 | 0.00% | −60,844−100.0% | Sold out |
| Diametric Capital, LP | 0 | $0 | 0.00% | −20,700−100.0% | Sold out |
| Bank of New York Mellon Corp | 0 | $0 | 0.00% | −14,966−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −12,853−100.0% | Sold out |
| D.A. Davidson & Co. | 0 | $0 | 0.00% | −10,800−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −10,450−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −10,726−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −10,664−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −4,120−100.0% | Sold out |
| Legal & General Group Plc | 0 | $0 | 0.00% | −1,934−100.0% | Sold out |
| Banque Cantonale Vaudoise | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Barclays PLC | 0 | $0 | 0.00% | −204−100.0% | Sold out |
| New York State Common Retirement Fund | 0 | $0 | 0.00% | −223−100.0% | Sold out |
| Credit Suisse AG | 0 | $0 | 0.00% | −13−100.0% | Sold out |
| Captrust Financial Advisors | 0 | $0 | 0.00% | −473−100.0% | Sold out |
| CoreCap Advisors, LLC | 0 | $0 | 0.00% | −142−100.0% | Sold out |
| Steward Financial Group LLC | 0 | $0 | 0.00% | −354−100.0% | Sold out |