Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 50
- −2 vs. Q3 2023
- Shares held
- 13.8M
- +1.25M (+9.9%) vs. Q3 2023
- Total value
- $143.0M
- +$127.8M (+839.6%) vs. Q3 2023
- New holders
- 6
- 10 more added
- Sold out
- 8
- 10 more reduced
2 institutions that held it in Q3 2023 haven't filed for Q4 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Novo Holdings A/S | 468,902 | $123.4M | 7.62% | 00.0% | Unchanged |
| Anson Funds Management LP | 4,297,699 | $6.32M | 1.22% | +138,127+3.3% | Added |
| Vanguard Group Inc | 1,643,757 | $2.42M | 0.00% | +86,161+5.5% | Added |
| ADAR1 Capital Management, LLC | 1,067,711 | $1.57M | 0.70% | +1,067,711 | New |
| Atlas Venture Life Science Advisors, LLC | 1,013,438 | $1.49M | 0.18% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $1.31M | 0.06% | 00.0% | Unchanged |
| Murchinson Ltd. | 862,700 | $1.27M | 0.22% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 547,465 | $805.0K | 0.00% | +300+0.1% | Added |
| BlackRock Inc. | 480,599 | $706.5K | 0.00% | −1,210−0.3% | Reduced |
| Geode Capital Management, LLC | 412,707 | $606.8K | 0.00% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 402,963 | $592.4K | 0.00% | −60,678−13.1% | Reduced |
| Acadian Asset Management LLC | 343,856 | $505.0K | 0.00% | +71,832+26.4% | Added |
| AWM Investment Company, Inc. | 333,400 | $490.1K | 0.06% | 00.0% | Unchanged |
| Millennium Management LLC | 148,857 | $218.8K | 0.00% | +29,163+24.4% | Added |
| Bridgeway Capital Management, LLC | 134,800 | $198.2K | 0.00% | 00.0% | Unchanged |
| State Street Corp | 130,511 | $191.9K | 0.00% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 125,000 | $183.8K | 0.04% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 122,802 | $180.5K | 0.00% | −6,695−5.2% | Reduced |
| Northern Trust Corp | 88,881 | $130.7K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 65,966 | $97.0K | 0.02% | +7,598+13.0% | Added |
| Citadel Advisors LLC | 32,274 | $47.4K | 0.00% | +32,274 | New |
| DLK Investment Management, LLC | 31,355 | $46.1K | 0.02% | +31,355 | New |
| Charles Schwab Investment Management Inc | 28,565 | $42.0K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 28,200 | $41.5K | 0.00% | 00.0% | Unchanged |
| Mackenzie Financial Corp | 21,462 | $31.5K | 0.00% | +4,264+24.8% | Added |
| Susquehanna International Group, LLP | 18,086 | $26.6K | 0.00% | −2,097−10.4% | Reduced |
| Bourgeon Capital Management LLC | 15,100 | $22.2K | 0.00% | 00.0% | Unchanged |
| Three Seasons Wealth, LLC | 15,000 | $22.1K | 0.02% | +15,000 | New |
| Morgan Stanley | 12,035 | $17.7K | 0.00% | +3,047+33.9% | Added |
| Two Sigma Securities, LLC | 10,301 | $15.1K | 0.00% | +10,301 | New |
| Dimensional Fund Advisors LP | 10,003 | $14.7K | 0.00% | −1,750−14.9% | Reduced |
| Texas Yale Capital Corp. | 10,000 | $14.7K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 6,400 | $9.41K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 5,750 | $8.45K | 0.00% | −3,032−34.5% | Reduced |
| Group One Trading, L.P. | 4,590 | $6.75K | 0.00% | −29,600−86.6% | Reduced |
| Federation des caisses Desjardins du Quebec | 730 | $1.07K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 600 | $882 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 533 | $784 | 0.00% | +18+3.5% | Added |
| Rhumbline Advisers | 458 | $673 | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 329 | $484 | 0.00% | −26,806−98.8% | Reduced |
| JPMorgan Chase & Co | 236 | $347 | 0.00% | 00.0% | Unchanged |
| FMR LLC | 189 | $278 | 0.00% | +189 | New |
| US Bancorp | 151 | $222 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $147 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 97 | $143 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 50 | $74 | 0.00% | −200−80.0% | Reduced |
| BNP Paribas Arbitrage, SA | 12 | $18 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1 | $1 | 0.00% | −571−99.8% | Reduced |
| Qube Research & Technologies Ltd | 1 | $1 | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 315 | $0 | 0.00% | +15+5.0% | Added |
| Rock Springs Capital Management LP | 0 | $0 | 0.00% | −57,373−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −18,627−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −17,023−100.0% | Sold out |
| ERn Financial, LLC | 0 | $0 | 0.00% | −15,766−100.0% | Sold out |
| WR Wealth Planners, LLC | 0 | $0 | 0.00% | −2,600−100.0% | Sold out |
| Cullen/Frost Bankers, Inc. | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Beaird Harris Wealth Management, LLC | 0 | $0 | 0.00% | −202−100.0% | Sold out |
| Heritage Wealth Advisors | 0 | $0 | 0.00% | −187−100.0% | Sold out |
| Atlas Venture Associates IX, LLC | – | – | – | – | Not filed |
| OUP Management Co., LLC | – | – | – | – | Not filed |