Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2024
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 48
- −6 vs. Q1 2024
- Shares held
- 13.9M
- +104.2K (+0.8%) vs. Q1 2024
- Total value
- $18.0M
- −$5.65M (−23.9%) vs. Q1 2024
- New holders
- 5
- 12 more added
- Sold out
- 11
- 8 more reduced
Compare with Q1 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q2 2024
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 3,750,450 | $4.88M | 0.70% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,770,525 | $2.30M | 0.00% | +117,093+7.1% | Added |
| Acadian Asset Management LLC | 1,071,860 | $1.39M | 0.00% | +309,262+40.6% | Added |
| Renaissance Technologies LLC | 975,952 | $1.27M | 0.00% | +121,492+14.2% | Added |
| ADAR1 Capital Management, LLC | 918,929 | $1.19M | 0.24% | −8,000−0.9% | Reduced |
| Alphabet Inc. | 889,979 | $1.16M | 0.06% | 00.0% | Unchanged |
| Murchinson Ltd. | 873,910 | $1.14M | 0.24% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 535,336 | $695.9K | 0.07% | −72,277−11.9% | Reduced |
| Geode Capital Management, LLC | 492,187 | $640.0K | 0.00% | +22,746+4.8% | Added |
| BlackRock Inc. | 483,402 | $628.4K | 0.00% | +6,506+1.4% | Added |
| Novo Holdings A/S | 468,902 | $609.6K | 0.03% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 333,400 | $433.4K | 0.06% | 00.0% | Unchanged |
| Citadel Advisors LLC | 312,034 | $405.6K | 0.00% | +312,034 | New |
| Bridgeway Capital Management, LLC | 184,800 | $240.2K | 0.01% | 00.0% | Unchanged |
| State Street Corp | 130,511 | $169.7K | 0.00% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 125,000 | $162.5K | 0.04% | 00.0% | Unchanged |
| Northern Trust Corp | 112,303 | $146.0K | 0.00% | −2,256−2.0% | Reduced |
| Millennium Management LLC | 98,518 | $128.1K | 0.00% | −49,354−33.4% | Reduced |
| Man Group plc | 73,469 | $95.5K | 0.00% | −140,557−65.7% | Reduced |
| Two Sigma Securities, LLC | 67,728 | $88.0K | 0.00% | +67,728 | New |
| Mackenzie Financial Corp | 32,729 | $42.5K | 0.00% | +4,287+15.1% | Added |
| DLK Investment Management, LLC | 31,355 | $40.8K | 0.02% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 28,565 | $37.1K | 0.00% | 00.0% | Unchanged |
| Shay Capital LLC | 25,000 | $32.5K | 0.01% | −281,967−91.9% | Reduced |
| Susquehanna International Group, LLP | 23,073 | $30.0K | 0.00% | +23,073 | New |
| Three Seasons Wealth, LLC | 15,000 | $19.5K | 0.01% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 10,003 | $13.0K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $13.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 6,971 | $9.06K | 0.00% | −16,726−70.6% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $8.32K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 5,558 | $7.22K | 0.00% | +366+7.0% | Added |
| FMR LLC | 2,889 | $3.76K | 0.00% | +500+20.9% | Added |
| WR Wealth Planners, LLC | 2,600 | $3.38K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 1,959 | $3.00K | 0.00% | +1,959 | New |
| Cullen/Frost Bankers, Inc. | 2,000 | $2.60K | 0.00% | +2,000 | New |
| Wells Fargo & Company | 1,000 | $1.30K | 0.00% | +460+85.2% | Added |
| Allworth Financial LP | 600 | $840 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 472 | $614 | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 458 | $595 | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 331 | $430 | 0.00% | −5,397−94.2% | Reduced |
| Advisor Group Holdings, Inc. | 295 | $384 | 0.00% | +248+527.7% | Added |
| Tower Research Capital LLC (TRC) | 276 | $359 | 0.00% | +60+27.8% | Added |
| CoreCap Advisors, LLC | 192 | $250 | 0.00% | +50+35.2% | Added |
| US Bancorp | 151 | $196 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $130 | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 30 | $39 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 12 | $16 | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 1 | $1 | 0.00% | 00.0% | Unchanged |
| Bank of Montreal | 0 | $0 | 0.00% | −79,500−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −79,401−100.0% | Sold out |
| Bailard, Inc. | 0 | $0 | 0.00% | −60,900−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −28,319−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −25,400−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −18,180−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −15,013−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −1,248−100.0% | Sold out |
| IFP Advisors, Inc | 0 | $0 | 0.00% | −650−100.0% | Sold out |
| Raleigh Capital Management Inc. | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| PFS Partners, LLC | 0 | $0 | 0.00% | −50−100.0% | Sold out |