Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2023
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 56
- +8 vs. Q1 2023
- Shares held
- 14.4M
- −3.23M (−18.4%) vs. Q1 2023
- Total value
- $20.8M
- −$4.63M (−18.2%) vs. Q1 2023
- New holders
- 11
- 10 more added
- Sold out
- 3
- 14 more reduced
Compare with Q1 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q2 2023
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 3,444,862 | $5.00M | 1.08% | −3,244,862−48.5% | Reduced |
| Vanguard Group Inc | 1,526,474 | $2.21M | 0.00% | +99,903+7.0% | Added |
| Atlas Venture Associates IX, LLC | 1,353,303 | $1.96M | 10.74% | −23,665−1.7% | Reduced |
| Atlas Venture Life Science Advisors, LLC | 1,013,438 | $1.47M | 0.18% | −17,722−1.7% | Reduced |
| Alphabet Inc. | 889,979 | $1.29M | 0.07% | 00.0% | Unchanged |
| Murchinson Ltd. | 762,700 | $1.11M | 0.14% | −42,921−5.3% | Reduced |
| Rock Springs Capital Management LP | 669,533 | $970.8K | 0.02% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 593,431 | $860.0K | 0.00% | +183,131+44.6% | Added |
| BlackRock Inc. | 523,804 | $759.5K | 0.00% | +33,991+6.9% | Added |
| Novo Holdings A/S | 468,902 | $679.9K | 0.05% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 467,960 | $678.5K | 0.00% | +467,960 | New |
| Geode Capital Management, LLC | 390,805 | $566.7K | 0.00% | +52,949+15.7% | Added |
| AWM Investment Company, Inc. | 383,400 | $555.9K | 0.08% | −917,000−70.5% | Reduced |
| Millennium Management LLC | 373,850 | $542.1K | 0.00% | −120,691−24.4% | Reduced |
| OUP Management Co., LLC | 249,070 | $361.2K | 0.62% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 173,539 | $250.0K | 0.00% | +173,539 | New |
| DAFNA Capital Management LLC | 125,000 | $181.3K | 0.05% | 00.0% | Unchanged |
| State Street Corp | 110,711 | $160.5K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 109,800 | $159.2K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 106,384 | $154.3K | 0.03% | −13,477−11.2% | Reduced |
| Group One Trading, L.P. | 91,970 | $133.4K | 0.01% | +4,866+5.6% | Added |
| Northern Trust Corp | 88,745 | $128.7K | 0.00% | +2,489+2.9% | Added |
| Two Sigma Investments, LP | 84,535 | $122.6K | 0.00% | +52,435+163.3% | Added |
| Squarepoint Ops LLC | 78,063 | $113.2K | 0.00% | +78,063 | New |
| Susquehanna International Group, LLP | 44,359 | $64.3K | 0.00% | +17,815+67.1% | Added |
| Charles Schwab Investment Management Inc | 28,565 | $41.4K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 27,071 | $39.3K | 0.00% | −14,452−34.8% | Reduced |
| Prudential Financial Inc | 24,400 | $35.4K | 0.00% | +24,400 | New |
| Royce & Associates LP | 22,851 | $33.1K | 0.00% | +22,851 | New |
| Virtu Financial LLC | 22,195 | $32.0K | 0.00% | +22,195 | New |
| Mackenzie Financial Corp | 17,198 | $25.3K | 0.00% | +17,198 | New |
| Bourgeon Capital Management LLC | 15,100 | $21.9K | 0.01% | −10,500−41.0% | Reduced |
| Citadel Advisors LLC | 14,956 | $21.7K | 0.00% | +14,956 | New |
| Bank of America Corp | 13,237 | $19.2K | 0.00% | −5,180−28.1% | Reduced |
| Dimensional Fund Advisors LP | 11,753 | $17.0K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $14.5K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 9,530 | $13.8K | 0.00% | −5,700−37.4% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $9.28K | 0.00% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 2,647 | $3.84K | 0.00% | −2,206−45.5% | Reduced |
| WR Wealth Planners, LLC | 2,600 | $3.77K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 2,189 | $3.26K | 0.00% | −935−29.9% | Reduced |
| Simplex Trading, LLC | 2,281 | $3.00K | 0.00% | +2,281 | New |
| Cullen/Frost Bankers, Inc. | 2,000 | $2.90K | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 730 | $1.06K | 0.00% | +30+4.3% | Added |
| Allworth Financial LP | 600 | $870 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 529 | $767 | 0.00% | +18+3.5% | Added |
| Rhumbline Advisers | 458 | $664 | 0.00% | +458 | New |
| PFS Partners, LLC | 250 | $358 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 236 | $342 | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 202 | $293 | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $271 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $219 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $145 | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $73 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 35 | $51 | 0.00% | −506−93.5% | Reduced |
| FMR LLC | 4 | $6 | 0.00% | +4 | New |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −64,388−100.0% | Sold out |
| Invesco Ltd. | 0 | $0 | 0.00% | −18,979−100.0% | Sold out |
| TD Waterhouse Canada Inc. | 0 | $0 | 0.00% | −300−100.0% | Sold out |