Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 100
- +17 vs. Q4 2021
- Shares held
- 20.2M
- +451.6K (+2.3%) vs. Q4 2021
- Total value
- $179.6M
- −$137.1M (−43.3%) vs. Q4 2021
- New holders
- 25
- 15 more added
- Sold out
- 8
- 23 more reduced
1 institution that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Aquilo Capital Management, LLC | 5,281,504 | $45.9M | 13.41% | +317,323+6.4% | Added |
| BlackRock Inc. | 1,794,081 | $15.6M | 0.00% | −4,696−0.3% | Reduced |
| BVF Inc | 1,585,615 | $13.8M | 0.55% | 00.0% | Unchanged |
| Atlas Venture Associates IX, LLC | 1,376,968 | $12.0M | 11.02% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,373,928 | $12.0M | 0.00% | +22,550+1.7% | Added |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $8.97M | 1.13% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 990,913 | $8.62M | 0.22% | +45,600+4.8% | Added |
| Alphabet Inc. | 889,979 | $7.74M | 0.25% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 586,642 | $5.10M | 0.00% | +223,108+61.4% | Added |
| Artal Group S.A. | 500,000 | $4.35M | 0.18% | 00.0% | Unchanged |
| State Street Corp | 497,185 | $4.33M | 0.00% | −346,770−41.1% | Reduced |
| Geode Capital Management, LLC | 471,189 | $4.10M | 0.00% | +14,005+3.1% | Added |
| Novo Holdings A/S | 468,902 | $4.08M | 0.22% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 406,946 | $3.54M | 0.00% | +35,724+9.6% | Added |
| Advisor Group Holdings, Inc. | 1,095 | $3.47M | 0.01% | −30−2.7% | Reduced |
| AWM Investment Company, Inc. | 372,755 | $3.24M | 0.42% | 00.0% | Unchanged |
| OUP Management Co., LLC | 249,070 | $2.17M | 1.65% | 00.0% | Unchanged |
| Northern Trust Corp | 238,452 | $2.07M | 0.00% | −14,748−5.8% | Reduced |
| Royal Bank of Canada | 196,097 | $1.71M | 0.00% | +13,502+7.4% | Added |
| Goldman Sachs Group Inc | 141,426 | $1.23M | 0.00% | +2,815+2.0% | Added |
| Granahan Investment Management Inc | 113,322 | $986.0K | 0.02% | −265,610−70.1% | Reduced |
| Renaissance Technologies LLC | 109,100 | $949.0K | 0.00% | +109,100 | New |
| JPMorgan Chase & Co | 81,172 | $706.0K | 0.00% | −16,013−16.5% | Reduced |
| Two Sigma Investments, LP | 78,908 | $686.0K | 0.00% | +78,908 | New |
| Letko, Brosseau & Associates Inc | 73,659 | $641.0K | 0.01% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 73,070 | $636.0K | 0.00% | −1,930−2.6% | Reduced |
| Morgan Stanley | 72,996 | $635.0K | 0.00% | +22,511+44.6% | Added |
| Knoll Capital Management, LLC | 70,000 | $609.0K | 0.38% | +70,000 | New |
| Susquehanna International Group, LLP | 67,084 | $584.0K | 0.00% | −8,099−10.8% | Reduced |
| Charles Schwab Investment Management Inc | 65,547 | $571.0K | 0.00% | 00.0% | Unchanged |
| Bourgeon Capital Management LLC | 63,096 | $549.0K | 0.12% | +11,850+23.1% | Added |
| Millennium Management LLC | 61,261 | $533.0K | 0.00% | +61,261 | New |
| Eversept Partners, LP | 59,639 | $518.9K | 0.05% | +59,639 | New |
| Nuveen Asset Management, LLC | 60,598 | $516.0K | 0.00% | 00.0% | Unchanged |
| Parametric Portfolio Associates LLC | 44,168 | $384.0K | 0.00% | +44,168 | New |
| D.A. Davidson & Co. | 43,800 | $381.0K | 0.00% | 00.0% | Unchanged |
| Sentinel Pension Advisors Inc | 42,000 | $365.0K | 0.12% | +11,800+39.1% | Added |
| Walleye Capital LLC | 40,009 | $348.0K | 0.01% | +40,009 | New |
| Stifel Financial Corp | 37,728 | $328.0K | 0.00% | +7,842+26.2% | Added |
| State of Wisconsin Investment Board | 31,600 | $275.0K | 0.00% | 00.0% | Unchanged |
| Marshall Wace, LLP | 26,027 | $227.0K | 0.00% | +26,027 | New |
| Williams Jones Wealth Management, LLC. | 26,000 | $226.0K | 0.00% | −49,000−65.3% | Reduced |
| Gsa Capital Partners LLP | 25,916 | $225.0K | 0.03% | +25,916 | New |
| Janney Montgomery Scott LLC | 25,500 | $222.0K | 0.00% | 00.0% | Unchanged |
| Rhumbline Advisers | 24,740 | $215.0K | 0.00% | +5,479+28.4% | Added |
| Trexquant Investment LP | 24,151 | $210.0K | 0.01% | +24,151 | New |
| Assenagon Asset Management S.A. | 23,123 | $201.0K | 0.00% | +23,123 | New |
| D. E. Shaw & Co., Inc. | 18,646 | $162.0K | 0.00% | +18,646 | New |
| Gofen & Glossberg LLC | 17,500 | $152.0K | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 17,123 | $149.0K | 0.00% | −36,605−68.1% | Reduced |
| Two Sigma Advisers, LP | 16,400 | $143.0K | 0.00% | +16,400 | New |
| Jane Street Group, LLC | 15,622 | $136.0K | 0.00% | +15,622 | New |
| Wells Fargo & Company | 14,283 | $124.0K | 0.00% | −8,411−37.1% | Reduced |
| Cubist Systematic Strategies, LLC | 14,144 | $123.0K | 0.00% | +14,144 | New |
| Deutsche Bank AG | 13,885 | $121.0K | 0.00% | −1,658−10.7% | Reduced |
| XTX Topco Ltd | 13,260 | $115.0K | 0.05% | +13,260 | New |
| Alliancebernstein L.P. | 12,934 | $113.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 12,423 | $108.0K | 0.00% | +3,655+41.7% | Added |
| American International Group, Inc. | 12,015 | $105.0K | 0.00% | −845−6.6% | Reduced |
| Manufacturers Life Insurance Company, The | 11,620 | $101.1K | 0.00% | −2,436−17.3% | Reduced |
| HRT Financial LP | 11,277 | $98.0K | 0.00% | +11,277 | New |
| State Board of Administration of Florida Retirement System | 11,007 | $96.0K | 0.00% | 00.0% | Unchanged |
| Engineers Gate Manager LP | 10,957 | $95.0K | 0.00% | +10,957 | New |
| Citadel Advisors LLC | 10,797 | $94.0K | 0.00% | +10,797 | New |
| California State Teachers Retirement System | 10,256 | $89.0K | 0.00% | −2,482−19.5% | Reduced |
| Radnor Capital Management, LLC | 10,000 | $87.0K | 0.02% | 00.0% | Unchanged |
| Bank of America Corp | 9,810 | $85.0K | 0.00% | −31,843−76.4% | Reduced |
| Allspring Global Investments Holdings, LLC | 9,048 | $78.0K | 0.00% | −1,138−11.2% | Reduced |
| Russell Investments Group, Ltd. | 7,250 | $63.0K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 6,346 | $55.0K | 0.00% | +6,346 | New |
| Barclays PLC | 3,930 | $35.0K | 0.00% | −25,441−86.6% | Reduced |
| Amalgamated Bank | 3,887 | $34.0K | 0.00% | +3,887 | New |
| Amalgamated Financial Corp. | 3,887 | $34.0K | 0.00% | +3,887 | New |
| Bedel Financial Consulting, Inc. | 3,837 | $33.0K | 0.01% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,581 | $22.0K | 0.00% | +114+4.6% | Added |
| BNP Paribas Arbitrage, SA | 2,508 | $21.8K | 0.00% | −6,489−72.1% | Reduced |
| Bollard Group LLC | 2,215 | $19.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,950 | $17.0K | 0.00% | −1,276−39.6% | Reduced |
| Banque Cantonale Vaudoise | 2,000 | $17.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,713 | $15.0K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 1,581 | $14.0K | 0.00% | −31,323−95.2% | Reduced |
| Patriot Financial Group Insurance Agency, LLC | 1,200 | $10.0K | 0.00% | −2,950−71.1% | Reduced |
| US Bancorp | 1,151 | $10.0K | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 1,000 | $9.00K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 755 | $7.00K | 0.00% | −32,327−97.7% | Reduced |
| Atlas Capital Advisors LLC | 727 | $6.33K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 516 | $4.00K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 500 | $3.54K | 0.00% | 00.0% | Unchanged |
| Steward Financial Group LLC | 354 | $3.00K | 0.00% | 00.0% | Unchanged |
| TCWP LLC | 425 | $3.00K | 0.00% | +425 | New |
| PFS Partners, LLC | 250 | $2.17K | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 282 | $2.00K | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $2.00K | 0.00% | 00.0% | Unchanged |
| Laurel Wealth Advisors LLC | 200 | $2.00K | 0.00% | 00.0% | Unchanged |
| Toth Financial Advisory Corp | 172 | $1.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $1.00K | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 103 | $1.00K | 0.00% | +103 | New |
| Quadrant Capital Group LLC | 106 | $1.00K | 0.00% | +106 | New |
| Investors Research Corp | 50 | $0 | 0.00% | 00.0% | Unchanged |