Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2022
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 79
- −19 vs. Q1 2022
- Shares held
- 21.0M
- +765.5K (+3.8%) vs. Q1 2022
- Total value
- $15.5M
- −$163.6M (−91.3%) vs. Q1 2022
- New holders
- 16
- 20 more added
- Sold out
- 35
- 22 more reduced
2 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q1 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q2 2022
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Aquilo Capital Management, LLC | 5,321,231 | $3.94M | 1.66% | +39,727+0.8% | Added |
| BVF Inc | 3,089,615 | $2.29M | 0.11% | +1,504,000+94.9% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $1.02M | 2.32% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,245,992 | $924.0K | 0.00% | −127,936−9.3% | Reduced |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $764.0K | 0.13% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 939,017 | $696.0K | 0.00% | +829,917+760.7% | Added |
| Alphabet Inc. | 889,979 | $659.0K | 0.04% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 770,710 | $571.0K | 0.02% | −220,203−22.2% | Reduced |
| BlackRock Inc. | 690,753 | $513.0K | 0.00% | −1,103,328−61.5% | Reduced |
| D. E. Shaw & Co., Inc. | 649,334 | $481.0K | 0.00% | +630,688+3,382.4% | Added |
| Artal Group S.A. | 500,000 | $371.0K | 0.02% | 00.0% | Unchanged |
| Novo Holdings A/S | 468,902 | $347.0K | 0.02% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 437,280 | $324.0K | 0.00% | +358,372+454.2% | Added |
| Millennium Management LLC | 314,643 | $233.0K | 0.00% | +253,382+413.6% | Added |
| Goldman Sachs Group Inc | 303,201 | $225.0K | 0.00% | +161,775+114.4% | Added |
| Geode Capital Management, LLC | 290,258 | $215.0K | 0.00% | −180,931−38.4% | Reduced |
| Oasis Management Co Ltd. | 288,000 | $213.0K | 0.04% | +288,000 | New |
| Dimensional Fund Advisors LP | 284,956 | $212.0K | 0.00% | −121,990−30.0% | Reduced |
| OUP Management Co., LLC | 249,070 | $185.0K | 0.25% | 00.0% | Unchanged |
| Morgan Stanley | 194,431 | $144.0K | 0.00% | +121,435+166.4% | Added |
| Two Sigma Advisers, LP | 176,157 | $131.0K | 0.00% | +159,757+974.1% | Added |
| AQR Capital Management LLC | 155,474 | $115.0K | 0.00% | +155,474 | New |
| Assenagon Asset Management S.A. | 131,020 | $97.0K | 0.00% | +107,897+466.6% | Added |
| Citadel Advisors LLC | 108,351 | $80.0K | 0.00% | +97,554+903.5% | Added |
| Ergoteles LLC | 102,408 | $76.0K | 0.00% | +102,408 | New |
| State Street Corp | 100,384 | $74.0K | 0.00% | −396,801−79.8% | Reduced |
| Acadian Asset Management LLC | 94,977 | $70.0K | 0.00% | +94,977 | New |
| Letko, Brosseau & Associates Inc | 73,659 | $55.0K | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 69,968 | $52.0K | 0.00% | −168,484−70.7% | Reduced |
| Knoll Capital Management, LLC | 70,000 | $52.0K | 0.03% | 00.0% | Unchanged |
| Kingsbury Capital Investment Advisors LLC | 60,844 | $45.0K | 0.06% | +60,844 | New |
| Susquehanna International Group, LLP | 54,145 | $40.0K | 0.00% | −12,939−19.3% | Reduced |
| Sentinel Pension Advisors Inc | 42,000 | $31.0K | 0.01% | 00.0% | Unchanged |
| Marshall Wace, LLP | 36,369 | $27.0K | 0.00% | +10,342+39.7% | Added |
| BNP Paribas Arbitrage, SA | 27,176 | $20.1K | 0.00% | +24,668+983.6% | Added |
| Stifel Financial Corp | 26,228 | $19.0K | 0.00% | −11,500−30.5% | Reduced |
| Tower Research Capital LLC (TRC) | 25,077 | $19.0K | 0.00% | +12,654+101.9% | Added |
| Group One Trading, L.P. | 24,244 | $18.0K | 0.00% | +24,244 | New |
| Diametric Capital, LP | 20,700 | $15.0K | 0.01% | +20,700 | New |
| Williams Jones Wealth Management, LLC. | 19,000 | $14.0K | 0.00% | −7,000−26.9% | Reduced |
| Bank of America Corp | 18,575 | $14.0K | 0.00% | +8,765+89.3% | Added |
| Bourgeon Capital Management LLC | 17,600 | $13.0K | 0.00% | −45,496−72.1% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $13.0K | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 17,664 | $13.0K | 0.00% | +17,664 | New |
| Bank of New York Mellon Corp | 14,966 | $11.0K | 0.00% | −58,104−79.5% | Reduced |
| Citigroup Inc | 14,362 | $11.0K | 0.00% | +12,781+808.4% | Added |
| Boothbay Fund Management, LLC | 12,853 | $10.0K | 0.00% | +12,853 | New |
| LMR Partners LLP | 11,508 | $9.00K | 0.00% | +11,508 | New |
| D.A. Davidson & Co. | 10,800 | $8.00K | 0.00% | −33,000−75.3% | Reduced |
| Gsa Capital Partners LLP | 10,450 | $8.00K | 0.00% | −15,466−59.7% | Reduced |
| Prelude Capital Management, LLC | 10,726 | $8.00K | 0.00% | +10,726 | New |
| Dynamic Technology Lab Private Ltd | 10,664 | $8.00K | 0.00% | +10,664 | New |
| Simplex Trading, LLC | 9,300 | $6.00K | 0.00% | +2,954+46.5% | Added |
| Russell Investments Group, Ltd. | 6,400 | $4.00K | 0.00% | −850−11.7% | Reduced |
| FMR LLC | 4,120 | $3.00K | 0.00% | +4,017+3,900.0% | Added |
| Advisor Group Holdings, Inc. | 2,795 | $2.00K | 0.00% | +1,700+155.3% | Added |
| Federated Hermes, Inc. | 2,579 | $2.00K | 0.00% | +2,579 | New |
| JPMorgan Chase & Co | 1,275 | $1.00K | 0.00% | −79,897−98.4% | Reduced |
| Wells Fargo & Company | 891 | $1.00K | 0.00% | −13,392−93.8% | Reduced |
| Legal & General Group Plc | 1,934 | $1.00K | 0.00% | −647−25.1% | Reduced |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,950 | $1.00K | 0.00% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 2,000 | $1.00K | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 2,000 | $1.00K | 0.00% | +1,000+100.0% | Added |
| UBS Group AG | 755 | $1.00K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 500 | $410 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 250 | $186 | 0.00% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 223 | $0 | 0.00% | −16,900−98.7% | Reduced |
| Barclays PLC | 204 | $0 | 0.00% | −3,726−94.8% | Reduced |
| US Bancorp | 151 | $0 | 0.00% | −1,000−86.9% | Reduced |
| Captrust Financial Advisors | 473 | $0 | 0.00% | −43−8.3% | Reduced |
| Steward Financial Group LLC | 354 | $0 | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $0 | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 282 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $0 | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $0 | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $0 | 0.00% | 00.0% | Unchanged |
| Credit Suisse AG | 13 | $0 | 0.00% | +13 | New |
| Allworth Financial LP | 102 | $0 | 0.00% | +102 | New |
| CoreCap Advisors, LLC | 142 | $0 | 0.00% | +142 | New |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −586,642−100.0% | Sold out |
| AWM Investment Company, Inc. | 0 | $0 | 0.00% | −372,755−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −196,097−100.0% | Sold out |
| Granahan Investment Management Inc | 0 | $0 | 0.00% | −113,322−100.0% | Sold out |
| Charles Schwab Investment Management Inc | 0 | $0 | 0.00% | −65,547−100.0% | Sold out |
| Eversept Partners, LP | 0 | $0 | 0.00% | −59,639−100.0% | Sold out |
| Nuveen Asset Management, LLC | 0 | $0 | 0.00% | −60,598−100.0% | Sold out |
| Walleye Capital LLC | 0 | $0 | 0.00% | −40,009−100.0% | Sold out |
| State of Wisconsin Investment Board | 0 | $0 | 0.00% | −31,600−100.0% | Sold out |
| Janney Montgomery Scott LLC | 0 | $0 | 0.00% | −25,500−100.0% | Sold out |
| Rhumbline Advisers | 0 | $0 | 0.00% | −24,740−100.0% | Sold out |
| Trexquant Investment LP | 0 | $0 | 0.00% | −24,151−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −15,622−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | 0 | $0 | 0.00% | −14,144−100.0% | Sold out |
| Deutsche Bank AG | 0 | $0 | 0.00% | −13,885−100.0% | Sold out |
| XTX Topco Ltd | 0 | $0 | 0.00% | −13,260−100.0% | Sold out |
| Alliancebernstein L.P. | 0 | $0 | 0.00% | −12,934−100.0% | Sold out |
| American International Group, Inc. | 0 | $0 | 0.00% | −12,015−100.0% | Sold out |
| Manufacturers Life Insurance Company, The | 0 | $0 | 0.00% | −11,620−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −11,277−100.0% | Sold out |
| State Board of Administration of Florida Retirement System | 0 | $0 | 0.00% | −11,007−100.0% | Sold out |