Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 88
- −6 vs. Q1 2021
- Shares held
- 17.5M
- −1.07M (−5.8%) vs. Q1 2021
- Total value
- $244.1M
- −$29.0M (−10.6%) vs. Q1 2021
- New holders
- 14
- 28 more added
- Sold out
- 20
- 21 more reduced
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Aquilo Capital Management, LLC | 3,829,209 | $53.5M | 13.89% | 00.0% | Unchanged |
| BVF Inc | 2,137,978 | $29.8M | 1.12% | 00.0% | Unchanged |
| BlackRock Inc. | 1,778,822 | $24.8M | 0.00% | +2,226+0.1% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $19.2M | 3.38% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,276,790 | $17.8M | 0.00% | +170,094+15.4% | Added |
| Rock Springs Capital Management LP | 965,928 | $13.5M | 0.27% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $12.4M | 0.25% | 00.0% | Unchanged |
| State Street Corp | 810,738 | $11.3M | 0.00% | −545,805−40.2% | Reduced |
| Artal Group S.A. | 500,000 | $6.98M | 0.16% | 00.0% | Unchanged |
| Novo Holdings A/S | 468,902 | $6.55M | 0.29% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 438,837 | $6.13M | 0.00% | +4,049+0.9% | Added |
| Geode Capital Management, LLC | 413,761 | $5.78M | 0.00% | +50,150+13.8% | Added |
| Dimensional Fund Advisors LP | 374,443 | $5.23M | 0.00% | +31,937+9.3% | Added |
| AWM Investment Company, Inc. | 372,755 | $5.20M | 0.51% | 00.0% | Unchanged |
| Granahan Investment Management Inc | 332,639 | $4.64M | 0.09% | −9,474−2.8% | Reduced |
| Northern Trust Corp | 260,886 | $3.64M | 0.00% | +21,308+8.9% | Added |
| Goldman Sachs Group Inc | 136,262 | $1.90M | 0.00% | −119,538−46.7% | Reduced |
| JPMorgan Chase & Co | 115,856 | $1.62M | 0.00% | +47,287+69.0% | Added |
| Letko, Brosseau & Associates Inc | 73,659 | $1.03M | 0.01% | 00.0% | Unchanged |
| Morgan Stanley | 69,772 | $974.0K | 0.00% | −119,177−63.1% | Reduced |
| Bank of New York Mellon Corp | 66,595 | $930.0K | 0.00% | +3,423+5.4% | Added |
| Nuveen Asset Management, LLC | 64,042 | $894.0K | 0.00% | −308−0.5% | Reduced |
| Charles Schwab Investment Management Inc | 60,496 | $845.0K | 0.00% | +7,138+13.4% | Added |
| New York State Common Retirement Fund | 49,891 | $696.0K | 0.00% | −8,638−14.8% | Reduced |
| Stifel Financial Corp | 49,069 | $685.0K | 0.00% | +500+1.0% | Added |
| Susquehanna International Group, LLP | 41,458 | $579.0K | 0.00% | −27,725−40.1% | Reduced |
| Wells Fargo & Company | 39,847 | $556.0K | 0.00% | +21,927+122.4% | Added |
| Citigroup Inc | 39,330 | $549.0K | 0.00% | −46,618−54.2% | Reduced |
| D.A. Davidson & Co. | 34,000 | $475.0K | 0.01% | +500+1.5% | Added |
| California State Teachers Retirement System | 33,446 | $467.0K | 0.00% | +2,523+8.2% | Added |
| Parametric Portfolio Associates LLC | 29,947 | $418.0K | 0.00% | −1,490−4.7% | Reduced |
| IndexIQ Advisors LLC | 27,484 | $384.0K | 0.01% | −1,984−6.7% | Reduced |
| Rafferty Asset Management, LLC | 23,898 | $334.0K | 0.00% | −45,065−65.3% | Reduced |
| Janney Montgomery Scott LLC | 23,500 | $328.0K | 0.00% | +8,500+56.7% | Added |
| Rhumbline Advisers | 18,565 | $259.0K | 0.00% | +126+0.7% | Added |
| Gofen & Glossberg LLC | 17,500 | $244.0K | 0.01% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 17,369 | $241.0K | 0.00% | −31,798−64.7% | Reduced |
| Manufacturers Life Insurance Company, The | 15,941 | $223.0K | 0.00% | +2,484+18.5% | Added |
| Deutsche Bank AG | 15,215 | $213.0K | 0.00% | +1,262+9.0% | Added |
| Alliancebernstein L.P. | 14,234 | $199.0K | 0.00% | +3,400+31.4% | Added |
| American International Group, Inc. | 13,559 | $189.0K | 0.00% | +1,643+13.8% | Added |
| Summit Global Investments | 13,100 | $183.0K | 0.01% | +13,100 | New |
| Citadel Advisors LLC | 11,812 | $165.0K | 0.00% | −8,268−41.2% | Reduced |
| ProShare Advisors LLC | 11,608 | $162.0K | 0.00% | +11,608 | New |
| State Board of Administration of Florida Retirement System | 11,007 | $154.0K | 0.00% | +11,007 | New |
| ExodusPoint Capital Management, LP | 10,933 | $153.0K | 0.00% | +10,933 | New |
| Advisor Group Holdings, Inc. | 10,063 | $143.0K | 0.00% | −32,150−76.2% | Reduced |
| Voya Investment Management LLC | 10,124 | $141.0K | 0.00% | +10,124 | New |
| Radnor Capital Management, LLC | 10,000 | $140.0K | 0.05% | 00.0% | Unchanged |
| MetLife Investment Management | 9,977 | $139.3K | 0.00% | +7,949+392.0% | Added |
| Tower Research Capital LLC (TRC) | 8,384 | $117.0K | 0.00% | +5,238+166.5% | Added |
| Bank of America Corp | 7,701 | $107.0K | 0.00% | −11,118−59.1% | Reduced |
| Metropolitan Life Insurance Co | 6,987 | $97.5K | 0.00% | +1,802+34.8% | Added |
| Barclays PLC | 5,564 | $77.0K | 0.00% | −16,076−74.3% | Reduced |
| Bedel Financial Consulting, Inc. | 3,837 | $54.0K | 0.02% | +3,837 | New |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,459 | $48.0K | 0.00% | +164+5.0% | Added |
| US Bancorp | 3,000 | $42.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,559 | $36.0K | 0.00% | +390+18.0% | Added |
| Institutional & Family Asset Management, LLC | 2,500 | $35.0K | 0.01% | +2,500 | New |
| Bollard Group LLC | 2,215 | $31.0K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 2,157 | $30.0K | 0.00% | +96+4.7% | Added |
| Liberty Wealth Management LLC | 2,000 | $28.0K | 0.01% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 2,000 | $28.0K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 2,060 | $28.0K | 0.00% | +100+5.1% | Added |
| UBS Group AG | 1,893 | $27.0K | 0.00% | −29,134−93.9% | Reduced |
| Ameritas Investment Partners, Inc. | 1,713 | $24.0K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,000 | $14.0K | 0.00% | −3,400−77.3% | Reduced |
| Cullen/Frost Bankers, Inc. | 1,000 | $14.0K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 947 | $13.2K | 0.00% | −13,382−93.4% | Reduced |
| Atlas Capital Advisors LLC | 727 | $10.1K | 0.00% | +727 | New |
| Geneos Wealth Management Inc. | 590 | $9.00K | 0.00% | −3,611−86.0% | Reduced |
| Penserra Capital Management LLC | 675 | $9.00K | 0.00% | +55+8.9% | Added |
| Brewin Dolphin Wealth Management Ltd | 600 | $8.38K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 516 | $7.00K | 0.00% | +223+76.1% | Added |
| Simplex Trading, LLC | 507 | $7.00K | 0.00% | +507 | New |
| Brewin Dolphin Ltd | 478 | $6.67K | 0.00% | 00.0% | Unchanged |
| C M Bidwell & Associates Ltd | 372 | $5.00K | 0.00% | +372 | New |
| Laurel Wealth Advisors LLC | 200 | $3.00K | 0.00% | +200 | New |
| Heritage Wealth Advisors | 187 | $2.61K | 0.00% | +187 | New |
| Toth Financial Advisory Corp | 172 | $2.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 115 | $2.00K | 0.00% | 00.0% | Unchanged |
| TCI Wealth Advisors, Inc. | 146 | $2.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 51 | $1.00K | 0.00% | 00.0% | Unchanged |
| Carroll Financial Associates, Inc. | 110 | $1.00K | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $1.00K | 0.00% | −10−16.7% | Reduced |
| BDO Wealth Advisors, LLC | 75 | $1.00K | 0.00% | +75 | New |
| Aspire Private Capital, LLC | 100 | $1.00K | 0.00% | +100 | New |
| Rockefeller Capital Management L.P. | 10 | $0 | 0.00% | 00.0% | Unchanged |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −181,578−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −49,602−100.0% | Sold out |
| California Public Employees Retirement System | 0 | $0 | 0.00% | −30,600−100.0% | Sold out |
| Sentinel Pension Advisors Inc | 0 | $0 | 0.00% | −26,410−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −27,960−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −24,878−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −24,528−100.0% | Sold out |
| State of Wisconsin Investment Board | 0 | $0 | 0.00% | −20,700−100.0% | Sold out |
| Vontobel Holding Ltd. | 0 | $0 | 0.00% | −13,865−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −12,635−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −11,496−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −9,473−100.0% | Sold out |