Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 59
- +9 vs. Q1 2026
- Shares held
- 21.5M
- +401.2K (+1.9%) vs. Q1 2026
- Total value
- $47.5M
- −$1.76M (−3.6%) vs. Q1 2026
- New holders
- 21
- 17 more added
- Sold out
- 12
- 6 more reduced
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| GSK plc | 9,190,606 | $20.3M | 3.37% | 00.0% | Unchanged |
| Pfizer Inc | 2,362,348 | $5.34M | 3.13% | 00.0% | Unchanged |
| Vanguard Capital Management LLC | 2,036,226 | $4.50M | 0.00% | +236,346+13.1% | Added |
| Renaissance Technologies LLC | 947,904 | $2.09M | 0.00% | −241,331−20.3% | Reduced |
| Alphabet Inc. | 889,979 | $1.97M | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 759,290 | $1.68M | 0.00% | +426,175+127.9% | Added |
| BlackRock, Inc. | 594,404 | $1.31M | 0.00% | +161,202+37.2% | Added |
| Geode Capital Management, LLC | 566,329 | $1.25M | 0.00% | +46,407+8.9% | Added |
| Raymond James Financial Inc | 521,705 | $1.15M | 0.00% | +521,705 | New |
| Two Sigma Investments, LP | 382,814 | $846.0K | 0.00% | −502,817−56.8% | Reduced |
| Arrowstreet Capital, Limited Partnership | 332,970 | $735.9K | 0.00% | +332,970 | New |
| Vanguard Fiduciary Trust Co | 287,648 | $635.7K | 0.00% | +23,533+8.9% | Added |
| Gsa Capital Partners LLP | 285,906 | $632.0K | 0.04% | +7,602+2.7% | Added |
| Dimensional Fund Advisors LP | 274,820 | $607.6K | 0.00% | +245,052+823.2% | Added |
| Goldman Sachs Group Inc | 256,985 | $567.9K | 0.00% | +256,985 | New |
| State Street Corp | 214,751 | $474.6K | 0.00% | 00.0% | Unchanged |
| Jane Street Group, LLC | 158,097 | $349.4K | 0.00% | +51,752+48.7% | Added |
| UBS Group AG | 139,680 | $308.7K | 0.00% | +136,671+4,542.1% | Added |
| Bridgeway Capital Management, LLC | 114,800 | $253.7K | 0.00% | 00.0% | Unchanged |
| Northern Trust Corp | 108,274 | $239.3K | 0.00% | −12,710−10.5% | Reduced |
| Point72 Asset Management, L.P. | 104,377 | $230.7K | 0.00% | +44,709+74.9% | Added |
| Ionic Capital Management LLC | 102,698 | $227.0K | 0.21% | −93,241−47.6% | Reduced |
| Federation des caisses Desjardins du Quebec | 91,900 | $202.2K | 0.00% | +91,900 | New |
| Shay Capital LLC | 72,391 | $160.0K | 0.02% | +2,037+2.9% | Added |
| Invesco Ltd. | 64,245 | $142.0K | 0.00% | +18,871+41.6% | Added |
| Simplex Trading, LLC | 61,312 | $135.5K | 0.00% | +31,008+102.3% | Added |
| Verdad Advisers, LP | 51,335 | $113.5K | 0.11% | +17,880+53.4% | Added |
| XTX Topco Ltd | 50,536 | $111.7K | 0.00% | +50,536 | New |
| Assenagon Asset Management S.A. | 37,272 | $82.4K | 0.00% | +18,636+100.0% | Added |
| American Century Companies Inc | 36,811 | $81.4K | 0.00% | +36,811 | New |
| Capital Asset Advisory Services LLC | 32,548 | $71.9K | 0.00% | 00.0% | Unchanged |
| Axxcess Wealth Management, LLC | 32,548 | $71.9K | 0.00% | +32,548 | New |
| Three Seasons Wealth, LLC | 30,000 | $66.3K | 0.01% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 28,565 | $63.1K | 0.00% | 00.0% | Unchanged |
| Vanguard Global Advisers, LLC | 25,446 | $56.2K | 0.00% | 00.0% | Unchanged |
| Global Retirement Partners, LLC | 25,000 | $55.3K | 0.00% | +25,000 | New |
| Oppenheimer & Co Inc | 22,850 | $50.5K | 0.00% | +22,850 | New |
| Millennium Management LLC | 19,298 | $42.6K | 0.00% | +19,298 | New |
| DLK Investment Management, LLC | 31,355 | $40.8K | 0.02% | +31,355 | New |
| Susquehanna Portfolio Strategies, LLC | 17,628 | $39.0K | 0.00% | +17,628 | New |
| Susquehanna Fundamental Investments, LLC | 16,095 | $35.6K | 0.00% | +16,095 | New |
| Qube Research & Technologies Ltd | 13,644 | $30.2K | 0.00% | +13,644 | New |
| SG Americas Securities, LLC | 11,268 | $25.0K | 0.00% | +11,268 | New |
| Group One Trading, L.P. | 10,869 | $24.0K | 0.00% | +10,869 | New |
| Two Sigma Securities, LLC | 10,576 | $23.4K | 0.00% | +10,576 | New |
| Prudential Financial Inc | 10,400 | $23.0K | 0.00% | +10,400 | New |
| Citigroup Inc | 9,625 | $21.3K | 0.00% | −9,510−49.7% | Reduced |
| FNY Investment Advisers, LLC | 8,300 | $18.0K | 0.01% | +3,000+56.6% | Added |
| Jones Financial Companies LLLP | 7,678 | $17.4K | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 2,014 | $4.00K | 0.00% | +2,014 | New |
| Morgan Stanley | 914 | $2.02K | 0.00% | −3,638−79.9% | Reduced |
| FMR LLC | 300 | $663 | 0.00% | +300 | New |
| Advisor Group Holdings, Inc. | 290 | $640 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 236 | $533 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 200 | $442 | 0.00% | 00.0% | Unchanged |
| Rialto Wealth Management, LLC | 172 | $381 | 0.00% | +172 | New |
| US Bancorp | 151 | $334 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 13 | $29 | 0.00% | +4+44.4% | Added |
| Farther Finance Advisors, LLC | 10 | $22 | 0.00% | 00.0% | Unchanged |
| Anson Funds Management LP | 0 | $0 | 0.00% | −843,912−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −376,458−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −194,301−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −157,072−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −40,128−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −39,400−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −20,314−100.0% | Sold out |
| Occudo Quantitative Strategies LP | 0 | $0 | 0.00% | −16,421−100.0% | Sold out |
| Intrepid Family Office LLC | 0 | $0 | 0.00% | −16,279−100.0% | Sold out |
| Torrey Growth & Income Advisors | 0 | $0 | 0.00% | −17,025−100.0% | Sold out |
| BNP Paribas Arbitrage, SA | 0 | $0 | 0.00% | −40−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −3−100.0% | Sold out |