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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

Q2 2026 vs. Q1 2026

How the institutions holding Spero Therapeutics, Inc. changed between Q1 2026 and Q2 2026.

All holders in Q2 2026All holders in Q1 2026

13F holders of SPRO: Q1 2026 compared with Q2 2026
MeasureQ1 2026Q2 2026Change
Holders5059+9
Shares20.6M21.4M+804.5K (+3.9%)
Value$48.3M$47.5M−$808.9K (−1.7%)

New holders (21)

Institutions that held Spero Therapeutics, Inc. at the end of Q2 2026 but not at the end of Q1 2026.

Institutions new to SPRO in Q2 2026
InstitutionSharesValue% of portfolio
Raymond James Financial Inc521,705$1.15M0.00%
Arrowstreet Capital, Limited Partnership332,970$735.9K0.00%
Goldman Sachs Group Inc256,985$567.9K0.00%
Federation des caisses Desjardins du Quebec91,900$202.2K0.00%
XTX Topco Ltd50,536$111.7K0.00%
American Century Companies Inc36,811$81.4K0.00%
Axxcess Wealth Management, LLC32,548$71.9K0.00%
Global Retirement Partners, LLC25,000$55.3K0.00%
Oppenheimer & Co Inc22,850$50.5K0.00%
Millennium Management LLC19,298$42.6K0.00%
DLK Investment Management, LLC31,355$40.8K0.02%
Susquehanna Portfolio Strategies, LLC17,628$39.0K0.00%
Susquehanna Fundamental Investments, LLC16,095$35.6K0.00%
Qube Research & Technologies Ltd13,644$30.2K0.00%
SG Americas Securities, LLC11,268$25.0K0.00%
Group One Trading, L.P.10,869$24.0K0.00%
Two Sigma Securities, LLC10,576$23.4K0.00%
Prudential Financial Inc10,400$23.0K0.00%
Royal Bank of Canada2,014$4.00K0.00%
FMR LLC300$6630.00%
Rialto Wealth Management, LLC172$3810.00%

Sold out (12)

Institutions that held Spero Therapeutics, Inc. at the end of Q1 2026 and filed for Q2 2026 without it.

Institutions that sold out of SPRO in Q2 2026
InstitutionShares, Q1 2026Value, Q1 2026
Anson Funds Management LP421,956$987.4K
Citadel Advisors LLC376,458$880.9K
Squarepoint Ops LLC194,301$454.7K
Marshall Wace, LLP157,072$367.5K
Quadrature Capital Ltd40,128$93.9K
Omers Administration Corp39,400$92.2K
Schonfeld Strategic Advisors LLC20,314$47.5K
Occudo Quantitative Strategies LP16,421$41.2K
Intrepid Family Office LLC16,279$38.1K
Torrey Growth & Income Advisors17,025$37.6K
BNP Paribas Arbitrage, SA40$94
Caitong International Asset Management Co., Ltd3$7