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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

Open-market trades, last 90 days

Open-market purchases (P) and sales (S) by Spero Therapeutics, Inc. insiders, counted by Form 4 filing. Trades with a flagged price and duplicate filings are left out.

Open-market buys
0 filings
Open-market sells
0 filings
Insiders trading
0
Net value
$0
Purchases minus sales

Insider roster

Directors, officers and 10% owners who have filed a Form 4 for Spero Therapeutics, Inc., current and former, most recent filer first. Last reported holding is the position after the last non-derivative trade in their latest filing.

Insider roster for Spero Therapeutics, Inc.
NameTitleLast reported holdingLast filingFilings, past year
Zack DebraChief Medical Officer162,311Aug 6, 20261
Thomas Frank EDirector85,000Jun 25, 20261
Pottage John C JrDirector85,000Jun 25, 20261
Deshpande MilindDirector101,454Jun 25, 20261
Vink Patrick V.J.J.Director85,000Jun 25, 20261
Jackson Scott ThomasDirector85,000Jun 25, 20261
Smith CynthiaDirector85,000Jun 25, 20261
Tregoning KathleenDirector85,000Jun 25, 20261
Rajavelu EstherSee Remarks986,851May 6, 20264
Keutzer TimothyChief Operating Officer742,506Feb 9, 20262
Mahadevia AnkitDirector703,294Sep 3, 20250
Shukla SathCEO & President1,736,883Feb 5, 20250
Joseph Tamara LChief Legal Officer531,615Feb 5, 20240
Hamed KamalChief Medical Officer788,117Feb 5, 20240
Aquilo Capital, L.P.10% Owner3,419,435IndirectSep 26, 20220
Aquilo Capital Management, LLC10% Owner3,419,435IndirectSep 26, 20220
Larkin CristinaChief Operating Officer63,581Feb 3, 20220
Melnick David A.Chief Medical Officer62,081Feb 3, 20220
Formela Jean FrancoisDirector–Aug 18, 20210

Insider trades

Each row adds up one type of transaction in one Form 4 filing. Only open-market purchases (P) and sales (S) are shown by default; use the filters to see grants, option exercises and other codes.

Insider trades
Filed (ET)Trade dateFiling delayInsiderTransactionSharesAvg priceValueHolding changeFlags
May 6, 2026 (view filing)May 42 daysRajavelu EstherSee RemarksSSale−25.2K$2.51−$63.4K−2.5%986.9K after
Feb 9, 2026 (view filing)Feb 63 daysRajavelu EstherSee RemarksSSale−87.9K$2.36−$207.5K−8.0%1.01M after2 lots
Feb 9, 2026 (view filing)Feb 63 daysKeutzer TimothyChief Operating OfficerSSale−18.7K$2.36−$44.0K−2.5%742.5K after
Feb 5, 2026 (view filing)Feb 2-43 daysLateKeutzer TimothyChief Operating OfficerSSale−46.6K$2.17−$101.2K−5.8%761.2K after3 lots
Feb 4, 2026 (view filing)Feb 22 daysRajavelu EstherSee RemarksSSale−18.4K$2.20−$40.6K−1.6%1.10M after
Nov 12, 2025 (view filing)Nov 75 daysRajavelu EstherSee RemarksSSale−40.3K$2.37−$95.4K−4.4%869.5K after
Sep 3, 2025 (view filing)Aug 286 daysLateMahadevia AnkitDirectorSSale−6.57K$1.97−$12.9K−0.9%703.3K after
Sep 3, 2025 (view filing)Aug 286 daysLateKeutzer TimothyChief Operating OfficerSSale−1.70K$1.97−$3.34K−0.2%739.7K after
Feb 5, 2025 (view filing)Feb 5Same dayKeutzer TimothyChief Operating OfficerSSale−56.5K$0.78−$44.1K−7.1%741.4K after3 lots
Feb 5, 2025 (view filing)Feb 5Same dayRajavelu EstherCFO & CBOSSale−20.7K$0.78−$16.1K−2.8%724.7K after
Feb 5, 2025 (view filing)Feb 5Same dayShukla SathCEO & PresidentSSale−155.3K$0.78−$121.2K−8.2%1.74M after3 lots
Feb 5, 2025 (view filing)Feb 5Same dayMahadevia AnkitDirectorSSale−69.2K$0.78−$54.0K−9.1%689.9K after2 lots
Nov 12, 2024 (view filing)Nov 7-85 daysRajavelu EstherCFO & CBOSSale−40.6K$1.31−$53.0K−9.7%379.3K after2 lots
Aug 29, 2024 (view filing)Aug 272 daysMahadevia AnkitDirectorSSale−5.91K$1.35−$7.98K−0.8%759.1K after
Aug 29, 2024 (view filing)Aug 272 daysKeutzer TimothyChief Operating OfficerSSale−2.21K$1.35−$2.99K−0.4%531.8K after
Aug 29, 2024 (view filing)Aug 272 daysShukla SathCEO & PresidentSSale−2.76K$1.35−$3.72K−0.2%1.14M after
Aug 6, 2024 (view filing)Aug 2-54 daysShukla SathCEO and PresidentSSale−32.4K$1.31−$42.6K−2.8%1.14M after2 lots
Feb 5, 2024 (view filing)Feb 23 daysKeutzer TimothyChief Operating OfficerSSale−31.0K$1.36−$42.1K−5.5%534.0K after
Feb 5, 2024 (view filing)Feb 23 daysMahadevia AnkitDirectorSSale−63.8K$1.37−$87.4K−7.9%745.0K after
Feb 5, 2024 (view filing)Feb 23 daysJoseph Tamara LChief Legal OfficerSSale−30.9K$1.37−$42.3K−5.5%531.6K after
Feb 5, 2024 (view filing)Feb 23 daysHamed KamalChief Medical OfficerSSale−28.1K$1.37−$38.5K−3.4%788.1K after
Feb 5, 2024 (view filing)Feb 2-53 daysShukla SathCEO and PresidentSSale−76.0K$1.42−$107.7K−6.1%1.18M after2 lots10b5-1
Sep 15, 2023 (view filing)Sep 132 daysHamed KamalChief Medical OfficerSSale−39.5K$1.27−$50.2K−6.4%576.5K after
Aug 30, 2023 (view filing)Aug 282 daysKeutzer TimothyChief Development OfficerSSale−1.85K$1.26−$2.34K−0.6%325.3K after
Aug 30, 2023 (view filing)Aug 282 daysJoseph Tamara LChief Legal OfficerSSale−1.85K$1.26−$2.34K−0.6%322.8K after
Aug 30, 2023 (view filing)Aug 282 daysMahadevia AnkitDirectorSSale−9.04K$1.26−$11.4K−1.1%788.8K after
Aug 30, 2023 (view filing)Aug 28-292 daysShukla SathCEO and PresidentSSale−6.02K$1.29−$7.75K−1.0%572.5K after2 lots10b5-1
Feb 6, 2023 (view filing)Feb 33 daysMahadevia AnkitCEO and PresidentSSale−12.3K$1.81−$22.2K−1.5%797.8K after
Feb 3, 2023 (view filing)Feb 21 dayKeutzer TimothyChief Operating OfficerSSale−3.39K$1.86−$6.31K−1.0%327.1K after
Feb 3, 2023 (view filing)Feb 21 dayJoseph Tamara LChief Legal OfficerSSale−3.39K$1.86−$6.31K−1.0%324.6K after
Feb 3, 2023 (view filing)Feb 21 dayShukla SathChief Financial OfficerSSale−9.50K$1.83−$17.4K−3.0%312.5K after
Sep 26, 2022 (view filing)3:32 PM ETSep 224 daysAquilo Capital, L.P. and 1 other10% OwnerSSaleCommon Stock, $0.001 par value−1.90M$2.25−$4.28M−35.7%3.42M after2 lots
Aug 30, 2022 (view filing)Aug 291 dayShukla SathChief Financial OfficerSSale−6.02K$0.89−$5.36K−9.7%56.1K after
Apr 28, 2022 (view filing)4:13 PM ETApr 262 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+39.7K$5.24+$208.0K+0.8%5.32M after
Mar 31, 2022 (view filing)3:51 PM ETMar 301 dayAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+50.0K$8.79+$439.4K+1.0%5.28M after2 lots
Mar 16, 2022 (view filing)4:23 PM ETMar 142 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+23.7K$7.63+$180.8K+0.5%5.23M after2 lots
Mar 2, 2022 (view filing)3:52 PM ETFeb 282 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+44.8K$9.53+$427.2K+0.9%5.21M after2 lots
Feb 23, 2022 (view filing)4:24 PM ETFeb 185 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+14.8K$9.24+$137.0K+0.3%5.16M after
Feb 1, 2022 (view filing)8:26 PM ETJan 311 dayAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+125.0K$11.59+$1.45M+2.5%5.15M after
Jan 26, 2022 (view filing)5:12 PM ETJan 242 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+1.60K$10.89+$17.4K0.0%5.02M after
Jan 20, 2022 (view filing)1:07 PM ETJan 182 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+48.5K$12.41+$602.0K+1.0%5.02M after
Jan 12, 2022 (view filing)4:43 PM ETJan 102 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+8.87K$12.93+$114.6K+0.2%4.97M after
Jan 3, 2022 (view filing)2:46 PM ETDec 29-31, 20215 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+250.5K$15.42+$3.86M+5.3%4.96M after3 lots
Dec 29, 2021 (view filing)Dec 272 daysMahadevia AnkitCEO and PresidentSSale−8.00K$14.58−$116.6K−5.3%144.0K after
Nov 2, 2021 (view filing)5:47 PM ETOct 294 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+150.0K$17.53+$2.63M+3.3%4.71M after
Oct 4, 2021 (view filing)11:36 AM ETSep 304 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+134.5K$18.65+$2.51M+3.0%4.56M after
Sep 15, 2021 (view filing)7:21 PM ETSep 13-142 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+46.4K$18.56+$860.5K+1.1%4.43M after2 lots
Sep 10, 2021 (view filing)5:21 PM ETSep 91 dayAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+24.7K$18.50+$457.8K+0.6%4.38M after
Sep 1, 2021 (view filing)5:42 PM ETAug 30-312 daysAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+92.7K$18.42+$1.71M+2.2%4.36M after2 lots
Aug 27, 2021 (view filing)5:11 PM ETAug 26-271 dayAquilo Capital, L.P. and 1 other10% OwnerPPurchaseCommon Stock, $0.001 par value+36.9K$16.67+$615.9K+0.9%4.27M after2 lots