Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q1 2023
Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 48
- −10 vs. Q4 2022
- Shares held
- 14.3M
- +44.6K (+0.3%) vs. Q4 2022
- Total value
- $20.6M
- −$3.97M (−16.2%) vs. Q4 2022
- New holders
- 3
- 15 more added
- Sold out
- 13
- 7 more reduced
2 institutions that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 3,344,862 | $4.85M | 1.17% | +325,254+10.8% | Added |
| Vanguard Group Inc | 1,426,571 | $2.07M | 0.00% | +372,183+35.3% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $2.00M | 9.37% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 1,300,400 | $1.89M | 0.26% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $1.50M | 0.20% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $1.29M | 0.07% | 00.0% | Unchanged |
| Murchinson Ltd. | 805,621 | $1.11M | 0.21% | +42,921+5.6% | Added |
| Rock Springs Capital Management LP | 669,533 | $970.8K | 0.02% | 00.0% | Unchanged |
| Millennium Management LLC | 494,541 | $717.0K | 0.00% | −381,857−43.6% | Reduced |
| BlackRock Inc. | 489,813 | $710.2K | 0.00% | +1,730+0.4% | Added |
| Novo Holdings A/S | 468,902 | $679.9K | 0.04% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 410,300 | $595.0K | 0.00% | +67,400+19.7% | Added |
| Geode Capital Management, LLC | 337,856 | $489.9K | 0.00% | +80,572+31.3% | Added |
| OUP Management Co., LLC | 249,070 | $361.2K | 0.72% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 125,000 | $181.3K | 0.05% | 00.0% | Unchanged |
| XTX Topco Ltd | 119,861 | $173.8K | 0.04% | −226,873−65.4% | Reduced |
| State Street Corp | 110,711 | $160.5K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 109,800 | $159.2K | 0.00% | +109,800 | New |
| Group One Trading, L.P. | 87,104 | $126.3K | 0.01% | +81,363+1,417.2% | Added |
| Northern Trust Corp | 86,256 | $125.1K | 0.00% | +16,672+24.0% | Added |
| Marshall Wace, LLP | 64,388 | $93.4K | 0.00% | +13,471+26.5% | Added |
| UBS Group AG | 41,523 | $60.2K | 0.00% | −4,159−9.1% | Reduced |
| Two Sigma Investments, LP | 32,100 | $46.5K | 0.00% | −7,695−19.3% | Reduced |
| Charles Schwab Investment Management Inc | 28,565 | $41.4K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 26,544 | $38.5K | 0.00% | −24,105−47.6% | Reduced |
| Bourgeon Capital Management LLC | 25,600 | $37.1K | 0.01% | +12,500+95.4% | Added |
| Invesco Ltd. | 18,979 | $27.5K | 0.00% | +6,906+57.2% | Added |
| Bank of America Corp | 18,417 | $26.7K | 0.00% | +10,479+132.0% | Added |
| Morgan Stanley | 15,230 | $22.1K | 0.00% | −1,847−10.8% | Reduced |
| Dimensional Fund Advisors LP | 11,753 | $17.0K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $14.5K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 6,400 | $9.28K | 0.00% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 4,853 | $7.04K | 0.00% | +4,744+4,352.3% | Added |
| Advisor Group Holdings, Inc. | 3,124 | $4.86K | 0.00% | +47+1.5% | Added |
| WR Wealth Planners, LLC | 2,600 | $3.77K | 0.00% | +2,600 | New |
| Cullen/Frost Bankers, Inc. | 2,000 | $2.90K | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 700 | $1.01K | 0.00% | +700 | New |
| Tower Research Capital LLC (TRC) | 541 | $1.00K | 0.00% | −32,623−98.4% | Reduced |
| Allworth Financial LP | 600 | $870 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 511 | $741 | 0.00% | +103+25.2% | Added |
| TD Waterhouse Canada Inc. | 300 | $456 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 250 | $358 | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 202 | $293 | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $271 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $219 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $145 | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $73 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 236 | $0 | 0.00% | 00.0% | Unchanged |
| Oasis Management Co Ltd. | 0 | $0 | 0.00% | −288,000−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −34,369−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −23,523−100.0% | Sold out |
| CI Private Wealth, LLC | 0 | $0 | 0.00% | −17,500−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −14,600−100.0% | Sold out |
| Sentinel Pension Advisors Inc | 0 | $0 | 0.00% | −12,000−100.0% | Sold out |
| Stifel Financial Corp | 0 | $0 | 0.00% | −10,766−100.0% | Sold out |
| Colony Group LLC | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −9,206−100.0% | Sold out |
| Belpointe Asset Management LLC | 0 | $0 | 0.00% | −4,560−100.0% | Sold out |
| BNP Paribas Arbitrage, SA | 0 | $0 | 0.00% | −668−100.0% | Sold out |
| Aspire Private Capital, LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Steward Financial Group LLC | 0 | $0 | 0.00% | −354−100.0% | Sold out |
| Gofen & Glossberg LLC | – | – | – | – | Not filed |
| CoreCap Advisors, LLC | – | – | – | – | Not filed |