Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q3 2023
Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 54
- −2 vs. Q2 2023
- Shares held
- 14.2M
- −176.8K (−1.2%) vs. Q2 2023
- Total value
- $17.2M
- −$3.66M (−17.6%) vs. Q2 2023
- New holders
- 5
- 12 more added
- Sold out
- 7
- 14 more reduced
Compare with Q2 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q3 2023
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 4,159,572 | $5.03M | 1.47% | +714,710+20.7% | Added |
| Vanguard Group Inc | 1,557,596 | $1.88M | 0.00% | +31,122+2.0% | Added |
| Atlas Venture Associates IX, LLC | 1,353,303 | $1.64M | 13.93% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 1,013,438 | $1.23M | 0.19% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $1.08M | 0.07% | 00.0% | Unchanged |
| Murchinson Ltd. | 862,700 | $1.04M | 0.16% | +100,000+13.1% | Added |
| Renaissance Technologies LLC | 547,165 | $662.0K | 0.00% | −46,266−7.8% | Reduced |
| BlackRock Inc. | 481,809 | $583.0K | 0.00% | −41,995−8.0% | Reduced |
| Novo Holdings A/S | 468,902 | $567.4K | 0.04% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 463,641 | $561.0K | 0.00% | −4,319−0.9% | Reduced |
| Geode Capital Management, LLC | 412,707 | $499.5K | 0.00% | +21,902+5.6% | Added |
| AWM Investment Company, Inc. | 333,400 | $403.4K | 0.06% | −50,000−13.0% | Reduced |
| Acadian Asset Management LLC | 272,024 | $327.0K | 0.00% | +98,485+56.8% | Added |
| OUP Management Co., LLC | 249,070 | $301.4K | 0.68% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 134,800 | $163.1K | 0.00% | +25,000+22.8% | Added |
| State Street Corp | 130,511 | $157.9K | 0.00% | +19,800+17.9% | Added |
| Squarepoint Ops LLC | 129,497 | $156.7K | 0.00% | +51,434+65.9% | Added |
| DAFNA Capital Management LLC | 125,000 | $151.3K | 0.05% | 00.0% | Unchanged |
| Millennium Management LLC | 119,694 | $144.8K | 0.00% | −254,156−68.0% | Reduced |
| Northern Trust Corp | 88,881 | $107.5K | 0.00% | +136+0.2% | Added |
| XTX Topco Ltd | 58,368 | $70.6K | 0.01% | −48,016−45.1% | Reduced |
| Rock Springs Capital Management LP | 57,373 | $69.4K | 0.00% | −612,160−91.4% | Reduced |
| Group One Trading, L.P. | 34,190 | $41.4K | 0.00% | −57,780−62.8% | Reduced |
| Charles Schwab Investment Management Inc | 28,565 | $34.6K | 0.00% | 00.0% | Unchanged |
| Prudential Financial Inc | 28,200 | $34.1K | 0.00% | +3,800+15.6% | Added |
| UBS Group AG | 27,135 | $32.8K | 0.00% | +64+0.2% | Added |
| Susquehanna International Group, LLP | 20,183 | $24.4K | 0.00% | −24,176−54.5% | Reduced |
| HRT Financial LP | 18,627 | $22.0K | 0.00% | +18,627 | New |
| Two Sigma Investments, LP | 17,023 | $20.6K | 0.00% | −67,512−79.9% | Reduced |
| Mackenzie Financial Corp | 17,198 | $20.1K | 0.00% | 00.0% | Unchanged |
| ERn Financial, LLC | 15,766 | $19.1K | 0.00% | +15,766 | New |
| Bourgeon Capital Management LLC | 15,100 | $18.3K | 0.00% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 11,753 | $14.2K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $12.1K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 8,988 | $10.9K | 0.00% | −542−5.7% | Reduced |
| Bank of America Corp | 8,782 | $10.6K | 0.00% | −4,455−33.7% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $7.74K | 0.00% | 00.0% | Unchanged |
| WR Wealth Planners, LLC | 2,600 | $3.15K | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 2,000 | $2.42K | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 730 | $883 | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 600 | $726 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 572 | $692 | 0.00% | +537+1,534.3% | Added |
| Wells Fargo & Company | 515 | $623 | 0.00% | −14−2.6% | Reduced |
| Rhumbline Advisers | 458 | $554 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 250 | $303 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 236 | $286 | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 202 | $245 | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $226 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $183 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $121 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 97 | $117 | 0.00% | −2,092−95.6% | Reduced |
| BNP Paribas Arbitrage, SA | 12 | $15 | 0.00% | +12 | New |
| Qube Research & Technologies Ltd | 1 | $1 | 0.00% | +1 | New |
| Royal Bank of Canada | 300 | $0 | 0.00% | +300 | New |
| Royce & Associates LP | 0 | $0 | 0.00% | −22,851−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −22,195−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −14,956−100.0% | Sold out |
| Federated Hermes, Inc. | 0 | $0 | 0.00% | −2,647−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −2,281−100.0% | Sold out |
| Investors Research Corp | 0 | $0 | 0.00% | −50−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −4−100.0% | Sold out |