Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2025
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 44
- +6 vs. Q1 2025
- Shares held
- 11.1M
- −4.02M (−26.6%) vs. Q1 2025
- Total value
- $32.1M
- +$21.3M (+195.6%) vs. Q1 2025
- New holders
- 16
- 9 more added
- Sold out
- 10
- 9 more reduced
Compare with Q1 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q2 2025
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Pfizer Inc | 2,362,348 | $6.85M | 1.19% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,950,381 | $5.66M | 0.00% | +186,761+10.6% | Added |
| Anson Funds Management LP | 1,615,469 | $4.68M | 0.86% | −2,183,463−57.5% | Reduced |
| Alphabet Inc. | 889,979 | $2.58M | 0.12% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 832,165 | $2.41M | 0.00% | −138,742−14.3% | Reduced |
| Schonfeld Strategic Advisors LLC | 510,834 | $1.48M | 0.01% | +510,834 | New |
| Geode Capital Management, LLC | 510,699 | $1.48M | 0.00% | −14,170−2.7% | Reduced |
| BlackRock, Inc. | 434,768 | $1.26M | 0.00% | −47,314−9.8% | Reduced |
| Monimus Capital Management, LP | 310,908 | $901.6K | 0.72% | 00.0% | Unchanged |
| EAM Investors, LLC | 239,140 | $693.5K | 0.11% | +239,140 | New |
| Stonepine Capital Management, LLC | 156,888 | $455.0K | 0.45% | +156,888 | New |
| State Street Corp | 153,451 | $445.0K | 0.00% | +4,540+3.0% | Added |
| Ionic Capital Management LLC | 150,000 | $435.0K | 0.49% | +150,000 | New |
| ADAR1 Capital Management, LLC | 143,917 | $417.4K | 0.07% | −657,360−82.0% | Reduced |
| Bridgeway Capital Management, LLC | 114,800 | $332.9K | 0.01% | −40,000−25.8% | Reduced |
| Acadian Asset Management LLC | 112,889 | $327.0K | 0.00% | −758,323−87.0% | Reduced |
| Citadel Advisors LLC | 103,786 | $301.0K | 0.00% | +42,470+69.3% | Added |
| Northern Trust Corp | 100,831 | $292.4K | 0.00% | −93−0.1% | Reduced |
| Susquehanna International Group, LLP | 69,814 | $202.5K | 0.00% | +69,814 | New |
| XTX Topco Ltd | 34,551 | $100.2K | 0.00% | +34,551 | New |
| Capital Asset Advisory Services LLC | 32,548 | $94.4K | 0.00% | +32,548 | New |
| Axxcess Wealth Management, LLC | 32,548 | $94.4K | 0.00% | +32,548 | New |
| Quadrature Capital Ltd | 31,205 | $90.5K | 0.00% | +31,205 | New |
| Three Seasons Wealth, LLC | 30,000 | $87.0K | 0.01% | 00.0% | Unchanged |
| Simplex Trading, LLC | 30,322 | $87.0K | 0.00% | +25,224+494.8% | Added |
| Charles Schwab Investment Management Inc | 28,565 | $82.8K | 0.00% | 00.0% | Unchanged |
| Cubist Systematic Strategies, LLC | 27,140 | $78.7K | 0.00% | +27,140 | New |
| Invesco Ltd. | 14,968 | $43.4K | 0.00% | +14,968 | New |
| Royal Bank of Canada | 11,478 | $34.0K | 0.00% | +11,478 | New |
| Texas Yale Capital Corp. | 10,000 | $29.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 9,221 | $26.7K | 0.00% | +2,250+32.3% | Added |
| Group One Trading, L.P. | 8,239 | $23.9K | 0.00% | +8,239 | New |
| UBS Group AG | 8,194 | $23.8K | 0.00% | +5,368+190.0% | Added |
| Bank of America Corp | 5,633 | $16.3K | 0.00% | +68+1.2% | Added |
| Raymond James Financial Inc | 3,082 | $8.94K | 0.00% | +3,082 | New |
| Cullen/Frost Bankers, Inc. | 2,000 | $5.80K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 603 | $1.75K | 0.00% | +603 | New |
| Advisor Group Holdings, Inc. | 290 | $841 | 0.00% | +290 | New |
| JPMorgan Chase & Co | 236 | $684 | 0.00% | −60,581−99.6% | Reduced |
| Wells Fargo & Company | 200 | $580 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $438 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $290 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 62 | $180 | 0.00% | +2+3.3% | Added |
| BNP Paribas Arbitrage, SA | 40 | $116 | 0.00% | +28+233.3% | Added |
| Murchinson Ltd. | 0 | $0 | 0.00% | −873,910−100.0% | Sold out |
| Atlas Venture Life Science Advisors, LLC | 0 | $0 | 0.00% | −305,255−100.0% | Sold out |
| Mackenzie Financial Corp | 0 | $0 | 0.00% | −209,031−100.0% | Sold out |
| DAFNA Capital Management LLC | 0 | $0 | 0.00% | −125,000−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −92,939−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −56,000−100.0% | Sold out |
| DLK Investment Management, LLC | 0 | $0 | 0.00% | −29,825−100.0% | Sold out |
| EP Wealth Advisors, LLC | 0 | $0 | 0.00% | −16,500−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −5,056−100.0% | Sold out |
| CoreCap Advisors, LLC | 0 | $0 | 0.00% | −50−100.0% | Sold out |