Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q1 2024
Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 54
- +4 vs. Q4 2023
- Shares held
- 13.8M
- −77.9K (−0.6%) vs. Q4 2023
- Total value
- $23.7M
- +$4.02M (+20.4%) vs. Q4 2023
- New holders
- 11
- 12 more added
- Sold out
- 7
- 12 more reduced
Compare with Q4 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q1 2024
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q4 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 3,750,450 | $6.45M | 0.48% | −547,249−12.7% | Reduced |
| Vanguard Group Inc | 1,653,432 | $2.84M | 0.00% | +9,675+0.6% | Added |
| ADAR1 Capital Management, LLC | 926,929 | $1.59M | 0.44% | −140,782−13.2% | Reduced |
| Alphabet Inc. | 889,979 | $1.53M | 0.06% | 00.0% | Unchanged |
| Murchinson Ltd. | 873,910 | $1.50M | 0.17% | +11,210+1.3% | Added |
| Renaissance Technologies LLC | 854,460 | $1.47M | 0.00% | +306,995+56.1% | Added |
| Acadian Asset Management LLC | 762,598 | $1.31M | 0.00% | +418,742+121.8% | Added |
| Atlas Venture Life Science Advisors, LLC | 607,613 | $1.05M | 0.10% | −405,825−40.0% | Reduced |
| BlackRock Inc. | 476,896 | $820.3K | 0.00% | −3,703−0.8% | Reduced |
| Geode Capital Management, LLC | 469,441 | $807.6K | 0.00% | +56,734+13.7% | Added |
| Novo Holdings A/S | 468,902 | $806.5K | 0.06% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 333,400 | $573.4K | 0.08% | 00.0% | Unchanged |
| Shay Capital LLC | 306,967 | $528.0K | 0.15% | +306,967 | New |
| Man Group plc | 214,026 | $368.1K | 0.00% | +214,026 | New |
| Bridgeway Capital Management, LLC | 184,800 | $317.9K | 0.01% | +50,000+37.1% | Added |
| Millennium Management LLC | 147,872 | $254.3K | 0.00% | −985−0.7% | Reduced |
| State Street Corp | 130,511 | $224.5K | 0.00% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 125,000 | $215.0K | 0.05% | 00.0% | Unchanged |
| Northern Trust Corp | 114,559 | $197.0K | 0.00% | +25,678+28.9% | Added |
| Bank of Montreal | 79,500 | $139.9K | 0.00% | +79,500 | New |
| Squarepoint Ops LLC | 79,401 | $136.6K | 0.00% | −43,401−35.3% | Reduced |
| Bailard, Inc. | 60,900 | $104.7K | 0.00% | +60,900 | New |
| DLK Investment Management, LLC | 31,355 | $53.9K | 0.02% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 28,565 | $49.1K | 0.00% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 28,319 | $49.0K | 0.00% | +28,319 | New |
| Mackenzie Financial Corp | 28,442 | $48.9K | 0.00% | +6,980+32.5% | Added |
| Prudential Financial Inc | 25,400 | $43.7K | 0.00% | −2,800−9.9% | Reduced |
| Virtu Financial LLC | 18,180 | $31.0K | 0.00% | +18,180 | New |
| Three Seasons Wealth, LLC | 15,000 | $27.0K | 0.02% | 00.0% | Unchanged |
| XTX Topco Ltd | 15,013 | $25.8K | 0.00% | −50,953−77.2% | Reduced |
| Dimensional Fund Advisors LP | 10,003 | $17.2K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $17.2K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 7,899 | $13.6K | 0.00% | −4,136−34.4% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $11.0K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 5,728 | $9.85K | 0.00% | +5,399+1,641.0% | Added |
| Bank of America Corp | 5,192 | $8.93K | 0.00% | −558−9.7% | Reduced |
| WR Wealth Planners, LLC | 2,600 | $4.47K | 0.00% | +2,600 | New |
| FMR LLC | 2,389 | $4.11K | 0.00% | +2,200+1,164.0% | Added |
| Lazard Asset Management LLC | 1,248 | $2.00K | 0.00% | +1,248 | New |
| IFP Advisors, Inc | 650 | $1.12K | 0.00% | +650 | New |
| Allworth Financial LP | 600 | $1.03K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 540 | $929 | 0.00% | +7+1.3% | Added |
| Raleigh Capital Management Inc. | 500 | $860 | 0.00% | +500 | New |
| Rhumbline Advisers | 458 | $787 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 236 | $406 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 216 | $372 | 0.00% | +215+21,500.0% | Added |
| US Bancorp | 151 | $260 | 0.00% | 00.0% | Unchanged |
| CoreCap Advisors, LLC | 142 | $244 | 0.00% | +142 | New |
| GWM Advisors LLC | 100 | $172 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 50 | $86 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 47 | $81 | 0.00% | −50−51.5% | Reduced |
| Federation des caisses Desjardins du Quebec | 30 | $52 | 0.00% | −700−95.9% | Reduced |
| BNP Paribas Arbitrage, SA | 12 | $21 | 0.00% | 00.0% | Unchanged |
| Qube Research & Technologies Ltd | 1 | $2 | 0.00% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 0 | $0 | 0.00% | −402,963−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −32,274−100.0% | Sold out |
| Susquehanna International Group, LLP | 0 | $0 | 0.00% | −18,086−100.0% | Sold out |
| Bourgeon Capital Management LLC | 0 | $0 | 0.00% | −15,100−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −10,301−100.0% | Sold out |
| Group One Trading, L.P. | 0 | $0 | 0.00% | −4,590−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −315−100.0% | Sold out |