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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

13F holders, Q1 2024

Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
54
+4 vs. Q4 2023
Shares held
13.8M
−77.9K (−0.6%) vs. Q4 2023
Total value
$23.7M
+$4.02M (+20.4%) vs. Q4 2023
New holders
11
12 more added
Sold out
7
12 more reduced

Compare with Q4 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2024: 54 institutions
Q1 2021: 95 institutionsQ2 2021: 89 institutionsQ3 2021: 88 institutionsQ4 2021: 84 institutionsQ1 2022: 100 institutionsQ2 2022: 79 institutionsQ3 2022: 69 institutionsQ4 2022: 60 institutionsQ1 2023: 48 institutionsQ2 2023: 56 institutionsQ3 2023: 54 institutionsQ4 2023: 50 institutionsQ1 2024: 54 institutionsQ2 2024: 48 institutionsQ3 2024: 46 institutionsQ4 2024: 50 institutionsQ1 2025: 38 institutionsQ2 2025: 44 institutionsQ3 2025: 47 institutionsQ4 2025: 56 institutionsQ1 2026: 50 institutionsQ2 2026: 59 institutions
Value heldQ1 2024: $23.7M
Q1 2021: $273.1MQ2 2021: $244.2MQ3 2021: $338.3MQ4 2021: $316.7MQ1 2022: $176.1MQ2 2022: $15.5MQ3 2022: $39.7MQ4 2022: $24.6MQ1 2023: $20.6MQ2 2023: $20.8MQ3 2023: $17.2MQ4 2023: $19.6MQ1 2024: $23.7MQ2 2024: $18.0MQ3 2024: $16.5MQ4 2024: $16.1MQ1 2025: $10.9MQ2 2025: $32.1MQ3 2025: $21.3MQ4 2025: $49.2MQ1 2026: $48.3MQ2 2026: $47.5M
Institutions holding SPRO and their total value by quarter
QuarterHoldersValue
Q2 202659$47.5M
Q1 202650$48.3M
Q4 202556$49.2M
Q3 202547$21.3M
Q2 202544$32.1M
Q1 202538$10.9M
Q4 202450$16.1M
Q3 202446$16.5M
Q2 202448$18.0M
Q1 202454$23.7M
Q4 202350$19.6M
Q3 202354$17.2M
Q2 202356$20.8M
Q1 202348$20.6M
Q4 202260$24.6M
Q3 202269$39.7M
Q2 202279$15.5M
Q1 2022100$176.1M
Q4 202184$316.7M
Q3 202188$338.3M
Q2 202189$244.2M
Q1 202195$273.1M

Institutions, Q1 2024

Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q4 2023.

Institutions holding SPRO in Q1 2024
InstitutionSharesValue% of portfolioChange in sharesAction
Qube Research & Technologies Ltd1$20.00%00.0%Unchanged
BNP Paribas Arbitrage, SA12$210.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec30$520.00%−700−95.9%Reduced
Advisor Group Holdings, Inc.47$810.00%−50−51.5%Reduced
PFS Partners, LLC50$860.00%00.0%Unchanged
GWM Advisors LLC100$1720.00%00.0%Unchanged
CoreCap Advisors, LLC142$2440.00%+142New
US Bancorp151$2600.00%00.0%Unchanged
Tower Research Capital LLC (TRC)216$3720.00%+215+21,500.0%Added
JPMorgan Chase & Co236$4060.00%00.0%Unchanged
Rhumbline Advisers458$7870.00%00.0%Unchanged
Raleigh Capital Management Inc.500$8600.00%+500New
Wells Fargo & Company540$9290.00%+7+1.3%Added
Allworth Financial LP600$1.03K0.00%00.0%Unchanged
IFP Advisors, Inc650$1.12K0.00%+650New
Lazard Asset Management LLC1,248$2.00K0.00%+1,248New
FMR LLC2,389$4.11K0.00%+2,200+1,164.0%Added
WR Wealth Planners, LLC2,600$4.47K0.00%+2,600New
Bank of America Corp5,192$8.93K0.00%−558−9.7%Reduced
UBS Group AG5,728$9.85K0.00%+5,399+1,641.0%Added
Russell Investments Group, Ltd.6,400$11.0K0.00%00.0%Unchanged
Morgan Stanley7,899$13.6K0.00%−4,136−34.4%Reduced
Texas Yale Capital Corp.10,000$17.2K0.00%00.0%Unchanged
Dimensional Fund Advisors LP10,003$17.2K0.00%00.0%Unchanged
XTX Topco Ltd15,013$25.8K0.00%−50,953−77.2%Reduced
Three Seasons Wealth, LLC15,000$27.0K0.02%00.0%Unchanged
Virtu Financial LLC18,180$31.0K0.00%+18,180New
Prudential Financial Inc25,400$43.7K0.00%−2,800−9.9%Reduced
Mackenzie Financial Corp28,442$48.9K0.00%+6,980+32.5%Added
Gsa Capital Partners LLP28,319$49.0K0.00%+28,319New
Charles Schwab Investment Management Inc28,565$49.1K0.00%00.0%Unchanged
DLK Investment Management, LLC31,355$53.9K0.02%00.0%Unchanged
Bailard, Inc.60,900$104.7K0.00%+60,900New
Squarepoint Ops LLC79,401$136.6K0.00%−43,401−35.3%Reduced
Bank of Montreal79,500$139.9K0.00%+79,500New
Northern Trust Corp114,559$197.0K0.00%+25,678+28.9%Added
DAFNA Capital Management LLC125,000$215.0K0.05%00.0%Unchanged
State Street Corp130,511$224.5K0.00%00.0%Unchanged
Millennium Management LLC147,872$254.3K0.00%−985−0.7%Reduced
Bridgeway Capital Management, LLC184,800$317.9K0.01%+50,000+37.1%Added
Man Group plc214,026$368.1K0.00%+214,026New
Shay Capital LLC306,967$528.0K0.15%+306,967New
AWM Investment Company, Inc.333,400$573.4K0.08%00.0%Unchanged
Novo Holdings A/S468,902$806.5K0.06%00.0%Unchanged
Geode Capital Management, LLC469,441$807.6K0.00%+56,734+13.7%Added
BlackRock Inc.476,896$820.3K0.00%−3,703−0.8%Reduced
Atlas Venture Life Science Advisors, LLC607,613$1.05M0.10%−405,825−40.0%Reduced
Acadian Asset Management LLC762,598$1.31M0.00%+418,742+121.8%Added
Renaissance Technologies LLC854,460$1.47M0.00%+306,995+56.1%Added
Murchinson Ltd.873,910$1.50M0.17%+11,210+1.3%Added
Alphabet Inc.889,979$1.53M0.06%00.0%Unchanged
ADAR1 Capital Management, LLC926,929$1.59M0.44%−140,782−13.2%Reduced
Vanguard Group Inc1,653,432$2.84M0.00%+9,675+0.6%Added
Anson Funds Management LP3,750,450$6.45M0.48%−547,249−12.7%Reduced
Ameriprise Financial Inc0$00.00%−402,963−100.0%Sold out
Citadel Advisors LLC0$00.00%−32,274−100.0%Sold out
Susquehanna International Group, LLP0$00.00%−18,086−100.0%Sold out
Bourgeon Capital Management LLC0$00.00%−15,100−100.0%Sold out
Two Sigma Securities, LLC0$00.00%−10,301−100.0%Sold out
Group One Trading, L.P.0$00.00%−4,590−100.0%Sold out
Royal Bank of Canada0$00.00%−315−100.0%Sold out