Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 87
- −1 vs. Q2 2021
- Shares held
- 18.4M
- +885.8K (+5.1%) vs. Q2 2021
- Total value
- $338.2M
- +$94.2M (+38.6%) vs. Q2 2021
- New holders
- 6
- 22 more added
- Sold out
- 7
- 25 more reduced
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Aquilo Capital Management, LLC | 4,563,688 | $84.0M | 19.77% | +734,479+19.2% | Added |
| BVF Inc | 1,809,352 | $33.3M | 1.30% | −328,626−15.4% | Reduced |
| BlackRock Inc. | 1,802,528 | $33.2M | 0.00% | +23,706+1.3% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $25.4M | 8.43% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,292,498 | $23.8M | 0.00% | +15,708+1.2% | Added |
| Rock Springs Capital Management LP | 941,543 | $17.3M | 0.36% | −24,385−2.5% | Reduced |
| Alphabet Inc. | 889,979 | $16.4M | 0.39% | 00.0% | Unchanged |
| State Street Corp | 802,691 | $14.8M | 0.00% | −8,047−1.0% | Reduced |
| Granahan Investment Management Inc | 555,614 | $10.2M | 0.19% | +222,975+67.0% | Added |
| Artal Group S.A. | 500,000 | $9.21M | 0.23% | 00.0% | Unchanged |
| Novo Holdings A/S | 468,902 | $8.63M | 0.45% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 444,914 | $8.19M | 0.00% | +31,153+7.5% | Added |
| Ameriprise Financial Inc | 377,095 | $6.94M | 0.00% | −61,742−14.1% | Reduced |
| AWM Investment Company, Inc. | 372,755 | $6.86M | 0.67% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 329,633 | $6.07M | 0.00% | −44,810−12.0% | Reduced |
| Northern Trust Corp | 257,939 | $4.75M | 0.00% | −2,947−1.1% | Reduced |
| Royal Bank of Canada | 180,102 | $3.32M | 0.00% | +177,945+8,249.7% | Added |
| Goldman Sachs Group Inc | 137,579 | $2.53M | 0.00% | +1,317+1.0% | Added |
| Williams Jones Wealth Management, LLC. | 105,500 | $1.94M | 0.03% | +105,500 | New |
| JPMorgan Chase & Co | 104,934 | $1.93M | 0.00% | −10,922−9.4% | Reduced |
| Bank of New York Mellon Corp | 74,207 | $1.37M | 0.00% | +7,612+11.4% | Added |
| Nuveen Asset Management, LLC | 71,121 | $1.36M | 0.00% | +7,079+11.1% | Added |
| Letko, Brosseau & Associates Inc | 73,659 | $1.36M | 0.02% | 00.0% | Unchanged |
| New York State Common Retirement Fund | 71,220 | $1.31M | 0.00% | +21,329+42.8% | Added |
| Charles Schwab Investment Management Inc | 63,586 | $1.17M | 0.00% | +3,090+5.1% | Added |
| Brandywine Global Investment Management, LLC | 58,400 | $1.07M | 0.01% | +58,400 | New |
| Morgan Stanley | 56,501 | $1.04M | 0.00% | −13,271−19.0% | Reduced |
| Stifel Financial Corp | 47,316 | $871.0K | 0.00% | −1,753−3.6% | Reduced |
| D.A. Davidson & Co. | 43,000 | $792.0K | 0.01% | +9,000+26.5% | Added |
| Bourgeon Capital Management LLC | 41,746 | $769.0K | 0.16% | +41,746 | New |
| Susquehanna International Group, LLP | 39,748 | $732.0K | 0.00% | −1,710−4.1% | Reduced |
| IndexIQ Advisors LLC | 30,543 | $562.0K | 0.02% | +3,059+11.1% | Added |
| UBS Group AG | 28,822 | $530.0K | 0.00% | +26,929+1,422.6% | Added |
| Janney Montgomery Scott LLC | 26,000 | $479.0K | 0.00% | +2,500+10.6% | Added |
| Campbell & CO Investment Adviser LLC | 23,900 | $440.0K | 0.14% | +23,900 | New |
| Sentinel Pension Advisors Inc | 20,200 | $372.0K | 0.13% | +20,200 | New |
| Rhumbline Advisers | 19,590 | $361.0K | 0.00% | +1,025+5.5% | Added |
| Rafferty Asset Management, LLC | 18,789 | $346.0K | 0.00% | −5,109−21.4% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $322.0K | 0.01% | 00.0% | Unchanged |
| Citigroup Inc | 16,085 | $296.0K | 0.00% | −23,245−59.1% | Reduced |
| Deutsche Bank AG | 14,763 | $272.0K | 0.00% | −452−3.0% | Reduced |
| Manufacturers Life Insurance Company, The | 14,276 | $263.0K | 0.00% | −1,665−10.4% | Reduced |
| Bank of America Corp | 13,668 | $251.0K | 0.00% | +5,967+77.5% | Added |
| American International Group, Inc. | 13,245 | $244.0K | 0.00% | −314−2.3% | Reduced |
| California State Teachers Retirement System | 13,044 | $240.0K | 0.00% | −20,402−61.0% | Reduced |
| Alliancebernstein L.P. | 11,934 | $220.0K | 0.00% | −2,300−16.2% | Reduced |
| Parametric Portfolio Associates LLC | 11,308 | $208.0K | 0.00% | −18,639−62.2% | Reduced |
| State Board of Administration of Florida Retirement System | 11,007 | $203.0K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 10,617 | $195.0K | 0.00% | +10,617 | New |
| Voya Investment Management LLC | 10,124 | $186.0K | 0.00% | 00.0% | Unchanged |
| Radnor Capital Management, LLC | 10,000 | $184.0K | 0.11% | 00.0% | Unchanged |
| MetLife Investment Management | 9,977 | $183.7K | 0.00% | 00.0% | Unchanged |
| Barclays PLC | 9,965 | $183.0K | 0.00% | +4,401+79.1% | Added |
| Russell Investments Group, Ltd. | 8,147 | $149.0K | 0.00% | −9,222−53.1% | Reduced |
| Wells Fargo & Company | 7,766 | $144.0K | 0.00% | −32,081−80.5% | Reduced |
| Metropolitan Life Insurance Co | 6,987 | $128.6K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 4,343 | $80.0K | 0.00% | +3,396+358.6% | Added |
| Bedel Financial Consulting, Inc. | 3,837 | $71.0K | 0.02% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,553 | $65.0K | 0.00% | +94+2.7% | Added |
| Advisor Group Holdings, Inc. | 2,548 | $46.0K | 0.00% | −7,515−74.7% | Reduced |
| Institutional & Family Asset Management, LLC | 2,500 | $46.0K | 0.01% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,467 | $45.0K | 0.00% | −92−3.6% | Reduced |
| Bollard Group LLC | 2,215 | $41.0K | 0.00% | 00.0% | Unchanged |
| Liberty Wealth Management LLC | 2,000 | $37.0K | 0.01% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 2,000 | $37.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,713 | $32.0K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 1,260 | $23.0K | 0.00% | −800−38.8% | Reduced |
| Tower Research Capital LLC (TRC) | 1,007 | $19.0K | 0.00% | −7,377−88.0% | Reduced |
| US Bancorp | 1,000 | $18.0K | 0.00% | −2,000−66.7% | Reduced |
| Cullen/Frost Bankers, Inc. | 1,000 | $18.0K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,000 | $18.0K | 0.00% | 00.0% | Unchanged |
| Atlas Capital Advisors LLC | 727 | $13.4K | 0.00% | 00.0% | Unchanged |
| Penserra Capital Management LLC | 730 | $13.0K | 0.00% | +55+8.1% | Added |
| Brewin Dolphin Wealth Management Ltd | 600 | $11.0K | 0.00% | 00.0% | Unchanged |
| Geneos Wealth Management Inc. | 590 | $10.0K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 516 | $9.00K | 0.00% | 00.0% | Unchanged |
| Brewin Dolphin Ltd | 478 | $8.80K | 0.00% | 00.0% | Unchanged |
| C M Bidwell & Associates Ltd | 372 | $7.00K | 0.00% | 00.0% | Unchanged |
| Laurel Wealth Advisors LLC | 200 | $4.00K | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $3.44K | 0.00% | 00.0% | Unchanged |
| Toth Financial Advisory Corp | 172 | $3.00K | 0.00% | 00.0% | Unchanged |
| TCI Wealth Advisors, Inc. | 146 | $3.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 115 | $2.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $2.00K | 0.00% | +59+115.7% | Added |
| Carroll Financial Associates, Inc. | 110 | $2.00K | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $2.00K | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $1.00K | 0.00% | 00.0% | Unchanged |
| Summit Global Investments | 0 | $0 | 0.00% | −13,100−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −11,812−100.0% | Sold out |
| ProShare Advisors LLC | 0 | $0 | 0.00% | −11,608−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −10,933−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −507−100.0% | Sold out |
| BDO Wealth Advisors, LLC | 0 | $0 | 0.00% | −75−100.0% | Sold out |
| Rockefeller Capital Management L.P. | 0 | $0 | 0.00% | −10−100.0% | Sold out |