Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 60
- −9 vs. Q3 2022
- Shares held
- 14.2M
- −5.63M (−28.4%) vs. Q3 2022
- Total value
- $24.6M
- −$15.1M (−38.1%) vs. Q3 2022
- New holders
- 14
- 11 more added
- Sold out
- 23
- 17 more reduced
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 3,019,608 | $5.22M | 1.25% | +1,545,736+104.9% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $2.38M | 11.85% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 1,300,400 | $2.25M | 0.32% | −1,000,000−43.5% | Reduced |
| Vanguard Group Inc | 1,054,388 | $1.82M | 0.00% | +665+0.1% | Added |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $1.78M | 0.21% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $1.54M | 0.09% | 00.0% | Unchanged |
| Millennium Management LLC | 876,398 | $1.52M | 0.00% | +188,002+27.3% | Added |
| Murchinson Ltd. | 762,700 | $1.32M | 0.17% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 669,533 | $1.16M | 0.03% | −101,177−13.1% | Reduced |
| BlackRock Inc. | 488,083 | $844.4K | 0.00% | −204,055−29.5% | Reduced |
| Novo Holdings A/S | 468,902 | $811.2K | 0.05% | 00.0% | Unchanged |
| XTX Topco Ltd | 346,734 | $599.9K | 0.13% | +346,734 | New |
| Renaissance Technologies LLC | 342,900 | $593.0K | 0.00% | +128,200+59.7% | Added |
| Oasis Management Co Ltd. | 288,000 | $498.2K | 0.11% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 257,284 | $445.0K | 0.00% | −32,974−11.4% | Reduced |
| OUP Management Co., LLC | 249,070 | $430.9K | 0.70% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 125,000 | $216.3K | 0.06% | 00.0% | Unchanged |
| State Street Corp | 110,711 | $191.5K | 0.00% | +19,400+21.2% | Added |
| Northern Trust Corp | 69,584 | $120.4K | 0.00% | −379−0.5% | Reduced |
| Marshall Wace, LLP | 50,917 | $88.1K | 0.00% | −135,653−72.7% | Reduced |
| Susquehanna International Group, LLP | 50,649 | $87.6K | 0.00% | −18,637−26.9% | Reduced |
| UBS Group AG | 45,682 | $79.0K | 0.00% | +22,774+99.4% | Added |
| Two Sigma Investments, LP | 39,795 | $68.8K | 0.00% | +39,795 | New |
| Virtu Financial LLC | 34,369 | $59.0K | 0.01% | +34,369 | New |
| Tower Research Capital LLC (TRC) | 33,164 | $57.0K | 0.00% | +14,925+81.8% | Added |
| Charles Schwab Investment Management Inc | 28,565 | $49.4K | 0.00% | +28,565 | New |
| Two Sigma Securities, LLC | 23,523 | $40.7K | 0.01% | +23,523 | New |
| CI Private Wealth, LLC | 17,500 | $30.3K | 0.00% | +17,500 | New |
| Gofen & Glossberg LLC | 17,500 | $30.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 17,077 | $29.5K | 0.00% | −2,177−11.3% | Reduced |
| Prudential Financial Inc | 14,600 | $25.3K | 0.00% | +14,600 | New |
| Bourgeon Capital Management LLC | 13,100 | $22.7K | 0.01% | −7,500−36.4% | Reduced |
| Invesco Ltd. | 12,073 | $20.9K | 0.00% | +12,073 | New |
| Sentinel Pension Advisors Inc | 12,000 | $20.8K | 0.01% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 11,753 | $20.0K | 0.00% | +1,750+17.5% | Added |
| Stifel Financial Corp | 10,766 | $18.6K | 0.00% | −1,740−13.9% | Reduced |
| Texas Yale Capital Corp. | 10,000 | $17.3K | 0.00% | +10,000 | New |
| Colony Group LLC | 10,000 | $17.0K | 0.00% | +10,000 | New |
| Simplex Trading, LLC | 9,206 | $15.0K | 0.00% | +8,206+820.6% | Added |
| Bank of America Corp | 7,938 | $13.7K | 0.00% | −1,843−18.8% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $11.1K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 5,741 | $9.93K | 0.00% | −49,359−89.6% | Reduced |
| Belpointe Asset Management LLC | 4,560 | $7.89K | 0.00% | +4,560 | New |
| Advisor Group Holdings, Inc. | 3,077 | $5.00K | 0.00% | −21,740−87.6% | Reduced |
| Cullen/Frost Bankers, Inc. | 2,000 | $3.46K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 668 | $1.16K | 0.00% | +146+28.0% | Added |
| Allworth Financial LP | 600 | $1.04K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 408 | $706 | 0.00% | +5+1.2% | Added |
| TD Waterhouse Canada Inc. | 300 | $522 | 0.00% | −200−40.0% | Reduced |
| PFS Partners, LLC | 250 | $433 | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 202 | $349 | 0.00% | −80−28.4% | Reduced |
| Heritage Wealth Advisors | 187 | $324 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $261 | 0.00% | 00.0% | Unchanged |
| CoreCap Advisors, LLC | 142 | $246 | 0.00% | +142 | New |
| Federated Hermes, Inc. | 109 | $189 | 0.00% | −1,843−94.4% | Reduced |
| Aspire Private Capital, LLC | 100 | $173 | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $87 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 236 | $0 | 0.00% | −1,352−85.1% | Reduced |
| GWM Advisors LLC | 100 | $0 | 0.00% | +100 | New |
| Steward Financial Group LLC | 354 | $0 | 0.00% | +354 | New |
| Aquilo Capital Management, LLC | 0 | $0 | 0.00% | −3,403,210−100.0% | Sold out |
| BVF Inc | 0 | $0 | 0.00% | −1,929,376−100.0% | Sold out |
| Artal Group S.A. | 0 | $0 | 0.00% | −500,000−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −202,300−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −186,682−100.0% | Sold out |
| Letko, Brosseau & Associates Inc | 0 | $0 | 0.00% | −73,659−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −61,152−100.0% | Sold out |
| Goldman Sachs Group Inc | 0 | $0 | 0.00% | −55,438−100.0% | Sold out |
| Williams Jones Wealth Management, LLC. | 0 | $0 | 0.00% | −19,000−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −16,423−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −15,948−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −15,496−100.0% | Sold out |
| Weitzel Financial Services, Inc. | 0 | $0 | 0.00% | −14,200−100.0% | Sold out |
| LMR Partners LLP | 0 | $0 | 0.00% | −11,508−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −11,184−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −2,900−100.0% | Sold out |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | $0 | 0.00% | −1,950−100.0% | Sold out |
| Atlas Capital Advisors LLC | 0 | $0 | 0.00% | −727−100.0% | Sold out |
| Citigroup Inc | 0 | $0 | 0.00% | −495−100.0% | Sold out |
| Crewe Advisors LLC | 0 | $0 | 0.00% | −258−100.0% | Sold out |
| China Universal Asset Management Co., Ltd. | 0 | $0 | 0.00% | −329−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −43−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −110−100.0% | Sold out |