Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q4 2022
Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 60
- −9 vs. Q3 2022
- Shares held
- 14.2M
- −5.63M (−28.4%) vs. Q3 2022
- Total value
- $24.6M
- −$15.1M (−38.1%) vs. Q3 2022
- New holders
- 14
- 11 more added
- Sold out
- 23
- 17 more reduced
Compare with Q3 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q4 2022
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| JPMorgan Chase & Co | 236 | $0 | 0.00% | −1,352−85.1% | Reduced |
| GWM Advisors LLC | 100 | $0 | 0.00% | +100 | New |
| Steward Financial Group LLC | 354 | $0 | 0.00% | +354 | New |
| Investors Research Corp | 50 | $87 | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $173 | 0.00% | 00.0% | Unchanged |
| Federated Hermes, Inc. | 109 | $189 | 0.00% | −1,843−94.4% | Reduced |
| CoreCap Advisors, LLC | 142 | $246 | 0.00% | +142 | New |
| US Bancorp | 151 | $261 | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $324 | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 202 | $349 | 0.00% | −80−28.4% | Reduced |
| PFS Partners, LLC | 250 | $433 | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 300 | $522 | 0.00% | −200−40.0% | Reduced |
| Wells Fargo & Company | 408 | $706 | 0.00% | +5+1.2% | Added |
| Allworth Financial LP | 600 | $1.04K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 668 | $1.16K | 0.00% | +146+28.0% | Added |
| Cullen/Frost Bankers, Inc. | 2,000 | $3.46K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 3,077 | $5.00K | 0.00% | −21,740−87.6% | Reduced |
| Belpointe Asset Management LLC | 4,560 | $7.89K | 0.00% | +4,560 | New |
| Group One Trading, L.P. | 5,741 | $9.93K | 0.00% | −49,359−89.6% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $11.1K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 7,938 | $13.7K | 0.00% | −1,843−18.8% | Reduced |
| Simplex Trading, LLC | 9,206 | $15.0K | 0.00% | +8,206+820.6% | Added |
| Colony Group LLC | 10,000 | $17.0K | 0.00% | +10,000 | New |
| Texas Yale Capital Corp. | 10,000 | $17.3K | 0.00% | +10,000 | New |
| Stifel Financial Corp | 10,766 | $18.6K | 0.00% | −1,740−13.9% | Reduced |
| Dimensional Fund Advisors LP | 11,753 | $20.0K | 0.00% | +1,750+17.5% | Added |
| Sentinel Pension Advisors Inc | 12,000 | $20.8K | 0.01% | 00.0% | Unchanged |
| Invesco Ltd. | 12,073 | $20.9K | 0.00% | +12,073 | New |
| Bourgeon Capital Management LLC | 13,100 | $22.7K | 0.01% | −7,500−36.4% | Reduced |
| Prudential Financial Inc | 14,600 | $25.3K | 0.00% | +14,600 | New |
| Morgan Stanley | 17,077 | $29.5K | 0.00% | −2,177−11.3% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $30.0K | 0.00% | 00.0% | Unchanged |
| CI Private Wealth, LLC | 17,500 | $30.3K | 0.00% | +17,500 | New |
| Two Sigma Securities, LLC | 23,523 | $40.7K | 0.01% | +23,523 | New |
| Charles Schwab Investment Management Inc | 28,565 | $49.4K | 0.00% | +28,565 | New |
| Tower Research Capital LLC (TRC) | 33,164 | $57.0K | 0.00% | +14,925+81.8% | Added |
| Virtu Financial LLC | 34,369 | $59.0K | 0.01% | +34,369 | New |
| Two Sigma Investments, LP | 39,795 | $68.8K | 0.00% | +39,795 | New |
| UBS Group AG | 45,682 | $79.0K | 0.00% | +22,774+99.4% | Added |
| Susquehanna International Group, LLP | 50,649 | $87.6K | 0.00% | −18,637−26.9% | Reduced |
| Marshall Wace, LLP | 50,917 | $88.1K | 0.00% | −135,653−72.7% | Reduced |
| Northern Trust Corp | 69,584 | $120.4K | 0.00% | −379−0.5% | Reduced |
| State Street Corp | 110,711 | $191.5K | 0.00% | +19,400+21.2% | Added |
| DAFNA Capital Management LLC | 125,000 | $216.3K | 0.06% | 00.0% | Unchanged |
| OUP Management Co., LLC | 249,070 | $430.9K | 0.70% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 257,284 | $445.0K | 0.00% | −32,974−11.4% | Reduced |
| Oasis Management Co Ltd. | 288,000 | $498.2K | 0.11% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 342,900 | $593.0K | 0.00% | +128,200+59.7% | Added |
| XTX Topco Ltd | 346,734 | $599.9K | 0.13% | +346,734 | New |
| Novo Holdings A/S | 468,902 | $811.2K | 0.05% | 00.0% | Unchanged |
| BlackRock Inc. | 488,083 | $844.4K | 0.00% | −204,055−29.5% | Reduced |
| Rock Springs Capital Management LP | 669,533 | $1.16M | 0.03% | −101,177−13.1% | Reduced |
| Murchinson Ltd. | 762,700 | $1.32M | 0.17% | 00.0% | Unchanged |
| Millennium Management LLC | 876,398 | $1.52M | 0.00% | +188,002+27.3% | Added |
| Alphabet Inc. | 889,979 | $1.54M | 0.09% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $1.78M | 0.21% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,054,388 | $1.82M | 0.00% | +665+0.1% | Added |
| AWM Investment Company, Inc. | 1,300,400 | $2.25M | 0.32% | −1,000,000−43.5% | Reduced |
| Atlas Venture Associates IX, LLC | 1,376,968 | $2.38M | 11.85% | 00.0% | Unchanged |
| Anson Funds Management LP | 3,019,608 | $5.22M | 1.71% | +1,545,736+104.9% | Added |
| Aquilo Capital Management, LLC | 0 | $0 | 0.00% | −3,403,210−100.0% | Sold out |
| BVF Inc | 0 | $0 | 0.00% | −1,929,376−100.0% | Sold out |
| Artal Group S.A. | 0 | $0 | 0.00% | −500,000−100.0% | Sold out |
| Bank of Montreal | 0 | $0 | 0.00% | −202,300−100.0% | Sold out |
| AQR Capital Management LLC | 0 | $0 | 0.00% | −186,682−100.0% | Sold out |
| Letko, Brosseau & Associates Inc | 0 | $0 | 0.00% | −73,659−100.0% | Sold out |
| Acadian Asset Management LLC | 0 | $0 | 0.00% | −61,152−100.0% | Sold out |
| Goldman Sachs Group Inc | 0 | $0 | 0.00% | −55,438−100.0% | Sold out |
| Williams Jones Wealth Management, LLC. | 0 | $0 | 0.00% | −19,000−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −16,423−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −15,948−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −15,496−100.0% | Sold out |
| Weitzel Financial Services, Inc. | 0 | $0 | 0.00% | −14,200−100.0% | Sold out |
| LMR Partners LLP | 0 | $0 | 0.00% | −11,508−100.0% | Sold out |
| Man Group plc | 0 | $0 | 0.00% | −11,184−100.0% | Sold out |
| Quantbot Technologies LP | 0 | $0 | 0.00% | −2,900−100.0% | Sold out |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | $0 | 0.00% | −1,950−100.0% | Sold out |
| Atlas Capital Advisors LLC | 0 | $0 | 0.00% | −727−100.0% | Sold out |
| Citigroup Inc | 0 | $0 | 0.00% | −495−100.0% | Sold out |
| Crewe Advisors LLC | 0 | $0 | 0.00% | −258−100.0% | Sold out |
| China Universal Asset Management Co., Ltd. | 0 | $0 | 0.00% | −329−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −43−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −110−100.0% | Sold out |