Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 84
- −3 vs. Q3 2021
- Shares held
- 19.8M
- +1.42M (+7.7%) vs. Q3 2021
- Total value
- $316.7M
- −$21.6M (−6.4%) vs. Q3 2021
- New holders
- 10
- 25 more added
- Sold out
- 13
- 20 more reduced
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Aquilo Capital Management, LLC | 4,964,181 | $79.5M | 19.54% | +400,493+8.8% | Added |
| BlackRock Inc. | 1,798,777 | $28.8M | 0.00% | −3,751−0.2% | Reduced |
| BVF Inc | 1,585,615 | $25.4M | 0.92% | −223,737−12.4% | Reduced |
| Atlas Venture Associates IX, LLC | 1,376,968 | $22.0M | 9.62% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,351,378 | $21.6M | 0.00% | +58,880+4.6% | Added |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $16.5M | 1.52% | +1,031,160 | New |
| Rock Springs Capital Management LP | 945,313 | $15.1M | 0.35% | +3,770+0.4% | Added |
| Alphabet Inc. | 889,979 | $14.2M | 0.34% | 00.0% | Unchanged |
| State Street Corp | 843,955 | $13.5M | 0.00% | +41,264+5.1% | Added |
| Artal Group S.A. | 500,000 | $8.01M | 0.24% | 00.0% | Unchanged |
| Novo Holdings A/S | 468,902 | $7.51M | 0.36% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 457,184 | $7.32M | 0.00% | +12,270+2.8% | Added |
| Granahan Investment Management Inc | 378,932 | $6.07M | 0.12% | −176,682−31.8% | Reduced |
| AWM Investment Company, Inc. | 372,755 | $5.97M | 0.60% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 371,222 | $5.94M | 0.00% | +41,589+12.6% | Added |
| Ameriprise Financial Inc | 363,534 | $5.82M | 0.00% | −13,561−3.6% | Reduced |
| Northern Trust Corp | 253,200 | $4.05M | 0.00% | −4,739−1.8% | Reduced |
| OUP Management Co., LLC | 249,070 | $3.99M | 1.80% | +249,070 | New |
| Royal Bank of Canada | 182,595 | $2.92M | 0.00% | +2,493+1.4% | Added |
| Goldman Sachs Group Inc | 138,611 | $2.22M | 0.00% | +1,032+0.8% | Added |
| JPMorgan Chase & Co | 97,185 | $1.56M | 0.00% | −7,749−7.4% | Reduced |
| Susquehanna International Group, LLP | 75,183 | $1.20M | 0.00% | +35,435+89.1% | Added |
| Williams Jones Wealth Management, LLC. | 75,000 | $1.20M | 0.02% | −30,500−28.9% | Reduced |
| Bank of New York Mellon Corp | 75,000 | $1.20M | 0.00% | +793+1.1% | Added |
| Letko, Brosseau & Associates Inc | 73,659 | $1.18M | 0.02% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 65,547 | $1.05M | 0.00% | +1,961+3.1% | Added |
| New York State Common Retirement Fund | 53,728 | $860.0K | 0.00% | −17,492−24.6% | Reduced |
| Bourgeon Capital Management LLC | 51,246 | $820.0K | 0.17% | +9,500+22.8% | Added |
| Morgan Stanley | 50,485 | $808.0K | 0.00% | −6,016−10.6% | Reduced |
| Nuveen Asset Management, LLC | 60,598 | $780.0K | 0.00% | −10,523−14.8% | Reduced |
| D.A. Davidson & Co. | 43,800 | $701.0K | 0.01% | +800+1.9% | Added |
| Bank of America Corp | 41,653 | $667.0K | 0.00% | +27,985+204.7% | Added |
| Rafferty Asset Management, LLC | 34,958 | $560.0K | 0.00% | +16,169+86.1% | Added |
| UBS Group AG | 33,082 | $529.0K | 0.00% | +4,260+14.8% | Added |
| Citigroup Inc | 32,904 | $527.0K | 0.00% | +16,819+104.6% | Added |
| State of Wisconsin Investment Board | 31,600 | $506.0K | 0.00% | +31,600 | New |
| Sentinel Pension Advisors Inc | 30,200 | $484.0K | 0.15% | +10,000+49.5% | Added |
| Stifel Financial Corp | 29,886 | $479.0K | 0.00% | −17,430−36.8% | Reduced |
| Barclays PLC | 29,371 | $470.0K | 0.00% | +19,406+194.7% | Added |
| IndexIQ Advisors LLC | 28,689 | $459.0K | 0.02% | −1,854−6.1% | Reduced |
| Janney Montgomery Scott LLC | 25,500 | $408.0K | 0.00% | −500−1.9% | Reduced |
| Wells Fargo & Company | 22,694 | $363.0K | 0.00% | +14,928+192.2% | Added |
| Rhumbline Advisers | 19,261 | $308.0K | 0.00% | −329−1.7% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $280.0K | 0.01% | 00.0% | Unchanged |
| Deutsche Bank AG | 15,543 | $249.0K | 0.00% | +780+5.3% | Added |
| Manufacturers Life Insurance Company, The | 14,056 | $225.0K | 0.00% | −220−1.5% | Reduced |
| Alliancebernstein L.P. | 12,934 | $207.0K | 0.00% | +1,000+8.4% | Added |
| American International Group, Inc. | 12,860 | $206.0K | 0.00% | −385−2.9% | Reduced |
| California State Teachers Retirement System | 12,738 | $204.0K | 0.00% | −306−2.3% | Reduced |
| State Board of Administration of Florida Retirement System | 11,007 | $176.0K | 0.00% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 10,186 | $163.0K | 0.00% | +10,186 | New |
| Radnor Capital Management, LLC | 10,000 | $160.0K | 0.04% | 00.0% | Unchanged |
| MetLife Investment Management | 9,977 | $159.7K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 8,997 | $144.0K | 0.00% | +4,654+107.2% | Added |
| Tower Research Capital LLC (TRC) | 8,768 | $141.0K | 0.00% | +7,761+770.7% | Added |
| Russell Investments Group, Ltd. | 7,250 | $116.0K | 0.00% | −897−11.0% | Reduced |
| Metropolitan Life Insurance Co | 6,987 | $111.9K | 0.00% | 00.0% | Unchanged |
| Patriot Financial Group Insurance Agency, LLC | 4,150 | $66.0K | 0.01% | +4,150 | New |
| Bedel Financial Consulting, Inc. | 3,837 | $61.0K | 0.02% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,226 | $52.0K | 0.00% | −327−9.2% | Reduced |
| Legal & General Group Plc | 2,467 | $40.0K | 0.00% | 00.0% | Unchanged |
| Bollard Group LLC | 2,215 | $35.0K | 0.00% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 2,000 | $32.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,713 | $27.0K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 1,151 | $18.0K | 0.00% | +151+15.1% | Added |
| Advisor Group Holdings, Inc. | 1,125 | $17.0K | 0.00% | −1,423−55.8% | Reduced |
| Cullen/Frost Bankers, Inc. | 1,000 | $16.0K | 0.00% | 00.0% | Unchanged |
| Atlas Capital Advisors LLC | 727 | $11.6K | 0.00% | 00.0% | Unchanged |
| Brewin Dolphin Wealth Management Ltd | 600 | $10.0K | 0.00% | 00.0% | Unchanged |
| Geneos Wealth Management Inc. | 590 | $9.00K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 516 | $8.00K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 500 | $7.45K | 0.00% | +500 | New |
| C M Bidwell & Associates Ltd | 372 | $6.00K | 0.00% | 00.0% | Unchanged |
| Steward Financial Group LLC | 354 | $5.00K | 0.00% | +354 | New |
| Beaird Harris Wealth Management, LLC | 282 | $5.00K | 0.00% | +282 | New |
| PFS Partners, LLC | 250 | $4.00K | 0.00% | +250 | New |
| Laurel Wealth Advisors LLC | 200 | $3.00K | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $3.00K | 0.00% | 00.0% | Unchanged |
| Toth Financial Advisory Corp | 172 | $3.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $2.00K | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $2.00K | 0.00% | 00.0% | Unchanged |
| CoreCap Advisors, LLC | 142 | $2.00K | 0.00% | +142 | New |
| Carroll Financial Associates, Inc. | 110 | $1.00K | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $1.00K | 0.00% | 00.0% | Unchanged |
| Brandywine Global Investment Management, LLC | 0 | $0 | 0.00% | −58,400−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −23,900−100.0% | Sold out |
| Parametric Portfolio Associates LLC | 0 | $0 | 0.00% | −11,308−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −10,617−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −10,124−100.0% | Sold out |
| Institutional & Family Asset Management, LLC | 0 | $0 | 0.00% | −2,500−100.0% | Sold out |
| Liberty Wealth Management LLC | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Cutler Group LP | 0 | $0 | 0.00% | −1,260−100.0% | Sold out |
| Steward Partners Investment Advisory, LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −730−100.0% | Sold out |
| Brewin Dolphin Ltd | 0 | $0 | 0.00% | −478−100.0% | Sold out |
| TCI Wealth Advisors, Inc. | 0 | $0 | 0.00% | −146−100.0% | Sold out |
| Harbour Investments, Inc. | 0 | $0 | 0.00% | −115−100.0% | Sold out |