Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q4 2021
Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 84
- −4 vs. Q3 2021
- Shares held
- 19.8M
- +1.42M (+7.7%) vs. Q3 2021
- Total value
- $316.7M
- −$21.7M (−6.4%) vs. Q3 2021
- New holders
- 9
- 25 more added
- Sold out
- 13
- 20 more reduced
Compare with Q3 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q4 2021
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Carroll Financial Associates, Inc. | 110 | $1.00K | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $1.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $2.00K | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $2.00K | 0.00% | 00.0% | Unchanged |
| CoreCap Advisors, LLC | 142 | $2.00K | 0.00% | +142 | New |
| Laurel Wealth Advisors LLC | 200 | $3.00K | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $3.00K | 0.00% | 00.0% | Unchanged |
| Toth Financial Advisory Corp | 172 | $3.00K | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 250 | $4.00K | 0.00% | +250 | New |
| Steward Financial Group LLC | 354 | $5.00K | 0.00% | +354 | New |
| Beaird Harris Wealth Management, LLC | 282 | $5.00K | 0.00% | +282 | New |
| C M Bidwell & Associates Ltd | 372 | $6.00K | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 500 | $7.45K | 0.00% | +500 | New |
| Captrust Financial Advisors | 516 | $8.00K | 0.00% | 00.0% | Unchanged |
| Geneos Wealth Management Inc. | 590 | $9.00K | 0.00% | 00.0% | Unchanged |
| Brewin Dolphin Wealth Management Ltd | 600 | $10.0K | 0.00% | 00.0% | Unchanged |
| Atlas Capital Advisors LLC | 727 | $11.6K | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 1,000 | $16.0K | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 1,125 | $17.0K | 0.00% | −1,423−55.8% | Reduced |
| US Bancorp | 1,151 | $18.0K | 0.00% | +151+15.1% | Added |
| Ameritas Investment Partners, Inc. | 1,713 | $27.0K | 0.00% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 2,000 | $32.0K | 0.00% | 00.0% | Unchanged |
| Bollard Group LLC | 2,215 | $35.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,467 | $40.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,226 | $52.0K | 0.00% | −327−9.2% | Reduced |
| Bedel Financial Consulting, Inc. | 3,837 | $61.0K | 0.02% | 00.0% | Unchanged |
| Patriot Financial Group Insurance Agency, LLC | 4,150 | $66.0K | 0.01% | 00.0% | Unchanged |
| Metropolitan Life Insurance Co | 6,987 | $111.9K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 7,250 | $116.0K | 0.00% | −897−11.0% | Reduced |
| Tower Research Capital LLC (TRC) | 8,768 | $141.0K | 0.00% | +7,761+770.7% | Added |
| BNP Paribas Arbitrage, SA | 8,997 | $144.0K | 0.00% | +4,654+107.2% | Added |
| MetLife Investment Management | 9,977 | $159.7K | 0.00% | 00.0% | Unchanged |
| Radnor Capital Management, LLC | 10,000 | $160.0K | 0.04% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 10,186 | $163.0K | 0.00% | +10,186 | New |
| State Board of Administration of Florida Retirement System | 11,007 | $176.0K | 0.00% | 00.0% | Unchanged |
| California State Teachers Retirement System | 12,738 | $204.0K | 0.00% | −306−2.3% | Reduced |
| American International Group, Inc. | 12,860 | $206.0K | 0.00% | −385−2.9% | Reduced |
| Alliancebernstein L.P. | 12,934 | $207.0K | 0.00% | +1,000+8.4% | Added |
| Manufacturers Life Insurance Company, The | 14,056 | $225.0K | 0.00% | −220−1.5% | Reduced |
| Deutsche Bank AG | 15,543 | $249.0K | 0.00% | +780+5.3% | Added |
| Gofen & Glossberg LLC | 17,500 | $280.0K | 0.01% | 00.0% | Unchanged |
| Rhumbline Advisers | 19,261 | $308.0K | 0.00% | −329−1.7% | Reduced |
| Wells Fargo & Company | 22,694 | $363.0K | 0.00% | +14,928+192.2% | Added |
| Janney Montgomery Scott LLC | 25,500 | $408.0K | 0.00% | −500−1.9% | Reduced |
| IndexIQ Advisors LLC | 28,689 | $459.0K | 0.02% | −1,854−6.1% | Reduced |
| Barclays PLC | 29,371 | $470.0K | 0.00% | +19,406+194.7% | Added |
| Stifel Financial Corp | 29,886 | $479.0K | 0.00% | −17,430−36.8% | Reduced |
| Sentinel Pension Advisors Inc | 30,200 | $484.0K | 0.15% | +10,000+49.5% | Added |
| State of Wisconsin Investment Board | 31,600 | $506.0K | 0.00% | +31,600 | New |
| Citigroup Inc | 32,904 | $527.0K | 0.00% | +16,819+104.6% | Added |
| UBS Group AG | 33,082 | $529.0K | 0.00% | +4,260+14.8% | Added |
| Rafferty Asset Management, LLC | 34,958 | $560.0K | 0.00% | +16,169+86.1% | Added |
| Bank of America Corp | 41,653 | $667.0K | 0.00% | +27,985+204.7% | Added |
| D.A. Davidson & Co. | 43,800 | $701.0K | 0.01% | +800+1.9% | Added |
| Nuveen Asset Management, LLC | 60,598 | $780.0K | 0.00% | −10,523−14.8% | Reduced |
| Morgan Stanley | 50,485 | $808.0K | 0.00% | −6,016−10.6% | Reduced |
| Bourgeon Capital Management LLC | 51,246 | $820.0K | 0.17% | +9,500+22.8% | Added |
| New York State Common Retirement Fund | 53,728 | $860.0K | 0.00% | −17,492−24.6% | Reduced |
| Charles Schwab Investment Management Inc | 65,547 | $1.05M | 0.00% | +1,961+3.1% | Added |
| Letko, Brosseau & Associates Inc | 73,659 | $1.18M | 0.02% | 00.0% | Unchanged |
| Bank of New York Mellon Corp | 75,000 | $1.20M | 0.00% | +793+1.1% | Added |
| Williams Jones Wealth Management, LLC. | 75,000 | $1.20M | 0.02% | −30,500−28.9% | Reduced |
| Susquehanna International Group, LLP | 75,183 | $1.20M | 0.00% | +35,435+89.1% | Added |
| JPMorgan Chase & Co | 97,185 | $1.56M | 0.00% | −7,749−7.4% | Reduced |
| Goldman Sachs Group Inc | 138,611 | $2.22M | 0.00% | +1,032+0.8% | Added |
| Royal Bank of Canada | 182,595 | $2.92M | 0.00% | +2,493+1.4% | Added |
| OUP Management Co., LLC | 249,070 | $3.99M | 1.80% | +249,070 | New |
| Northern Trust Corp | 253,200 | $4.05M | 0.00% | −4,739−1.8% | Reduced |
| Ameriprise Financial Inc | 363,534 | $5.82M | 0.00% | −13,561−3.6% | Reduced |
| Dimensional Fund Advisors LP | 371,222 | $5.94M | 0.00% | +41,589+12.6% | Added |
| AWM Investment Company, Inc. | 372,755 | $5.97M | 0.60% | 00.0% | Unchanged |
| Granahan Investment Management Inc | 378,932 | $6.07M | 0.12% | −176,682−31.8% | Reduced |
| Geode Capital Management, LLC | 457,184 | $7.32M | 0.00% | +12,270+2.8% | Added |
| Novo Holdings A/S | 468,902 | $7.51M | 0.36% | 00.0% | Unchanged |
| Artal Group S.A. | 500,000 | $8.01M | 0.24% | 00.0% | Unchanged |
| State Street Corp | 843,955 | $13.5M | 0.00% | +41,264+5.1% | Added |
| Alphabet Inc. | 889,979 | $14.2M | 0.34% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 945,313 | $15.1M | 0.35% | +3,770+0.4% | Added |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $16.5M | 1.52% | +1,031,160 | New |
| Vanguard Group Inc | 1,351,378 | $21.6M | 0.00% | +58,880+4.6% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $22.0M | 9.62% | 00.0% | Unchanged |
| BVF Inc | 1,585,615 | $25.4M | 0.92% | −223,737−12.4% | Reduced |
| BlackRock Inc. | 1,798,777 | $28.8M | 0.00% | −3,751−0.2% | Reduced |
| Aquilo Capital Management, LLC | 4,964,181 | $79.5M | 19.54% | +400,493+8.8% | Added |
| Brandywine Global Investment Management, LLC | 0 | $0 | 0.00% | −58,400−100.0% | Sold out |
| Campbell & CO Investment Adviser LLC | 0 | $0 | 0.00% | −23,900−100.0% | Sold out |
| Parametric Portfolio Associates LLC | 0 | $0 | 0.00% | −11,308−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −10,617−100.0% | Sold out |
| Voya Investment Management LLC | 0 | $0 | 0.00% | −10,124−100.0% | Sold out |
| Institutional & Family Asset Management, LLC | 0 | $0 | 0.00% | −2,500−100.0% | Sold out |
| Liberty Wealth Management LLC | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Cutler Group LP | 0 | $0 | 0.00% | −1,260−100.0% | Sold out |
| Steward Partners Investment Advisory, LLC | 0 | $0 | 0.00% | −1,000−100.0% | Sold out |
| Penserra Capital Management LLC | 0 | $0 | 0.00% | −730−100.0% | Sold out |
| Brewin Dolphin Ltd | 0 | $0 | 0.00% | −478−100.0% | Sold out |
| TCI Wealth Advisors, Inc. | 0 | $0 | 0.00% | −146−100.0% | Sold out |
| Harbour Investments, Inc. | 0 | $0 | 0.00% | −115−100.0% | Sold out |