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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

13F holders, Q1 2021

Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
94
No complete 13F data for Q4 2020
Shares held
18.6M
No complete 13F data for Q4 2020
Total value
$273.1M
No complete 13F data for Q4 2020

Holders and value by quarter

Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ1 2021: 94 institutions
Q1 2021: 94 institutionsQ2 2021: 88 institutionsQ3 2021: 87 institutionsQ4 2021: 84 institutionsQ1 2022: 100 institutionsQ2 2022: 79 institutionsQ3 2022: 69 institutionsQ4 2022: 60 institutionsQ1 2023: 48 institutionsQ2 2023: 56 institutionsQ3 2023: 54 institutionsQ4 2023: 50 institutionsQ1 2024: 54 institutionsQ2 2024: 48 institutionsQ3 2024: 46 institutionsQ4 2024: 50 institutionsQ1 2025: 38 institutionsQ2 2025: 44 institutionsQ3 2025: 47 institutionsQ4 2025: 56 institutionsQ1 2026: 50 institutionsQ2 2026: 59 institutions
Value heldQ1 2021: $273.1M
Q1 2021: $273.1MQ2 2021: $244.1MQ3 2021: $338.2MQ4 2021: $316.7MQ1 2022: $176.1MQ2 2022: $15.5MQ3 2022: $39.7MQ4 2022: $24.6MQ1 2023: $20.6MQ2 2023: $20.8MQ3 2023: $17.2MQ4 2023: $19.6MQ1 2024: $23.7MQ2 2024: $18.0MQ3 2024: $16.5MQ4 2024: $16.1MQ1 2025: $10.9MQ2 2025: $32.1MQ3 2025: $21.3MQ4 2025: $49.2MQ1 2026: $48.3MQ2 2026: $47.5M
Institutions holding SPRO and their total value by quarter
QuarterHoldersValue
Q2 202659$47.5M
Q1 202650$48.3M
Q4 202556$49.2M
Q3 202547$21.3M
Q2 202544$32.1M
Q1 202538$10.9M
Q4 202450$16.1M
Q3 202446$16.5M
Q2 202448$18.0M
Q1 202454$23.7M
Q4 202350$19.6M
Q3 202354$17.2M
Q2 202356$20.8M
Q1 202348$20.6M
Q4 202260$24.6M
Q3 202269$39.7M
Q2 202279$15.5M
Q1 2022100$176.1M
Q4 202184$316.7M
Q3 202187$338.2M
Q2 202188$244.1M
Q1 202194$273.1M

Institutions, Q1 2021

Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc..

Livermore's 13F data starts with Q1 2021, so Q1 2021 has no change from the previous quarter.

Institutions holding SPRO in Q1 2021
InstitutionSharesValue% of portfolioChange in sharesAction
Aquilo Capital Management, LLC3,829,209$56.4M15.37%––
BVF Inc2,137,978$31.5M1.18%––
BlackRock Inc.1,776,596$26.2M0.00%––
Atlas Venture Associates IX, LLC1,376,968$20.3M3.41%––
State Street Corp1,356,543$20.0M0.00%––
Vanguard Group Inc1,106,696$16.3M0.00%––
Rock Springs Capital Management LP965,928$14.2M0.31%––
Alphabet Inc.889,979$13.1M0.53%––
Artal Group S.A.500,000$7.36M0.16%––
Novo Holdings A/S468,902$6.90M0.29%––
Ameriprise Financial Inc434,788$6.40M0.00%––
AWM Investment Company, Inc.372,755$5.49M0.61%––
Geode Capital Management, LLC363,611$5.35M0.00%––
Dimensional Fund Advisors LP342,506$5.04M0.00%––
Granahan Investment Management Inc342,113$5.04M0.11%––
Goldman Sachs Group Inc255,800$3.77M0.00%––
Northern Trust Corp239,578$3.53M0.00%––
Morgan Stanley188,949$2.78M0.00%––
Assenagon Asset Management S.A.181,578$2.67M0.01%––
Citigroup Inc85,948$1.26M0.00%––
Letko, Brosseau & Associates Inc73,659$1.08M0.01%––
Susquehanna International Group, LLP69,183$1.02M0.00%––
Rafferty Asset Management, LLC68,963$1.01M0.01%––
JPMorgan Chase & Co68,569$1.01M0.00%––
Nuveen Asset Management, LLC64,350$948.0K0.00%––
Bank of New York Mellon Corp63,172$931.0K0.00%––
New York State Common Retirement Fund58,529$862.0K0.00%––
Charles Schwab Investment Management Inc53,358$786.0K0.00%––
Alyeska Investment Group, L.P.49,602$730.0K0.01%––
Russell Investments Group, Ltd.49,167$723.0K0.00%––
Stifel Financial Corp48,569$714.0K0.00%––
Advisor Group Holdings, Inc.42,213$621.0K0.00%––
D.A. Davidson & Co.33,500$493.0K0.01%––
Parametric Portfolio Associates LLC31,437$463.0K0.00%––
UBS Group AG31,027$456.0K0.00%––
California State Teachers Retirement System30,923$455.0K0.00%––
California Public Employees Retirement System30,600$450.0K0.00%––
IndexIQ Advisors LLC29,468$434.0K0.02%––
Sentinel Pension Advisors Inc26,410$425.0K0.16%––
Los Angeles Capital Management LLC27,960$412.0K0.00%––
Qube Research & Technologies Ltd24,878$366.0K0.01%––
Two Sigma Advisers, LP24,528$361.0K0.00%––
Barclays PLC21,640$319.0K0.00%––
State of Wisconsin Investment Board20,700$305.0K0.00%––
Citadel Advisors LLC20,080$296.0K0.00%––
Bank of America Corp18,819$277.0K0.00%––
Rhumbline Advisers18,439$271.0K0.00%––
Wells Fargo & Company17,920$265.0K0.00%––
Gofen & Glossberg LLC17,500$258.0K0.01%––
Janney Montgomery Scott LLC15,000$221.0K0.00%––
BNP Paribas Arbitrage, SA14,329$210.9K0.00%––
Deutsche Bank AG13,953$205.0K0.00%––
Vontobel Holding Ltd.13,865$204.0K0.00%––
Manufacturers Life Insurance Company, The13,457$198.0K0.00%––
Millennium Management LLC12,635$186.0K0.00%––
American International Group, Inc.11,916$175.0K0.00%––
Jane Street Group, LLC11,496$169.0K0.00%––
Alliancebernstein L.P.10,834$159.0K0.00%––
Radnor Capital Management, LLC10,000$147.0K0.05%––
Federated Hermes, Inc.9,473$139.0K0.00%––
FMR LLC8,552$126.0K0.00%––
DekaBank Deutsche Girozentrale8,500$114.0K0.00%––
Metropolitan Life Insurance Co5,185$76.3K0.00%––
Geneos Wealth Management Inc.4,201$57.0K0.00%––
Zurcher Kantonalbank (Zurich Cantonalbank)3,295$49.0K0.00%––
Tower Research Capital LLC (TRC)3,146$46.0K0.00%––
US Bancorp3,000$44.0K0.00%––
Liberty Wealth Management LLC2,000$38.0K0.02%––
Bollard Group LLC2,215$33.0K0.00%––
Steward Partners Investment Advisory, LLC2,200$32.4K0.00%––
Legal & General Group Plc2,169$32.0K0.00%––
Panagora Asset Management Inc2,109$31.0K0.00%––
Royal Bank of Canada2,061$30.0K0.00%––
MetLife Investment Management2,028$29.9K0.00%––
Banque Cantonale Vaudoise2,000$29.0K0.00%––
Cutler Group LP1,960$28.0K0.00%––
Ameritas Investment Partners, Inc.1,713$25.0K0.00%––
Pacer Advisors, Inc.1,608$24.0K0.00%––
Cullen/Frost Bankers, Inc.1,000$15.0K0.00%––
Penserra Capital Management LLC620$9.00K0.00%––
Brewin Dolphin Wealth Management Ltd600$8.83K0.00%––
Bank of Montreal598$8.00K0.00%––
Brewin Dolphin Ltd478$7.04K0.00%––
Captrust Financial Advisors293$4.00K0.00%––
Toth Financial Advisory Corp172$3.00K0.00%––
Nisa Investment Advisors, LLC200$3.00K0.00%––
Harbour Investments, Inc.115$2.00K0.00%––
TCI Wealth Advisors, Inc.146$2.00K0.00%––
Daiwa Securities Group Inc.51$1.00K0.00%––
Carroll Financial Associates, Inc.110$1.00K0.00%––
Investors Research Corp60$1.00K0.00%––
Ellevest, Inc.6$00.00%––
Close Asset Management Ltd10$00.00%––
Rockefeller Capital Management L.P.10$00.00%––