Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q3 2024
Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 46
- −1 vs. Q2 2024
- Shares held
- 12.3M
- −1.05M (−7.8%) vs. Q2 2024
- Total value
- $16.5M
- −$871.6K (−5.0%) vs. Q2 2024
- New holders
- 6
- 5 more added
- Sold out
- 7
- 12 more reduced
1 institution that held it in Q2 2024 haven't filed for Q3 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q2 2024: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q3 2024
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2024.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Anson Funds Management LP | 3,750,450 | $5.03M | 0.68% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,763,620 | $2.36M | 0.00% | −6,905−0.4% | Reduced |
| Acadian Asset Management LLC | 1,071,860 | $1.44M | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 974,653 | $1.31M | 0.00% | −1,299−0.1% | Reduced |
| Alphabet Inc. | 889,979 | $1.19M | 0.06% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 743,459 | $996.2K | 0.17% | −175,470−19.1% | Reduced |
| BlackRock, Inc. | 484,820 | $649.7K | 0.00% | +484,820 | New |
| Geode Capital Management, LLC | 481,187 | $644.9K | 0.00% | −11,000−2.2% | Reduced |
| Novo Holdings A/S | 468,902 | $628.3K | 0.03% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 402,885 | $539.9K | 0.05% | −132,451−24.7% | Reduced |
| AWM Investment Company, Inc. | 333,400 | $446.8K | 0.05% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 184,800 | $247.6K | 0.01% | 00.0% | Unchanged |
| State Street Corp | 130,511 | $174.9K | 0.00% | 00.0% | Unchanged |
| DAFNA Capital Management LLC | 125,000 | $167.5K | 0.04% | 00.0% | Unchanged |
| Northern Trust Corp | 111,497 | $149.4K | 0.00% | −806−0.7% | Reduced |
| Citadel Advisors LLC | 81,425 | $109.1K | 0.00% | −230,609−73.9% | Reduced |
| Susquehanna International Group, LLP | 44,219 | $59.3K | 0.00% | +21,146+91.6% | Added |
| Man Group plc | 38,481 | $51.6K | 0.00% | −34,988−47.6% | Reduced |
| Millennium Management LLC | 32,172 | $43.1K | 0.00% | −66,346−67.3% | Reduced |
| Mackenzie Financial Corp | 31,903 | $42.8K | 0.00% | −826−2.5% | Reduced |
| DLK Investment Management, LLC | 31,355 | $42.0K | 0.02% | 00.0% | Unchanged |
| Three Seasons Wealth, LLC | 30,000 | $40.2K | 0.02% | +15,000+100.0% | Added |
| Charles Schwab Investment Management Inc | 28,565 | $38.3K | 0.00% | 00.0% | Unchanged |
| Shay Capital LLC | 25,000 | $33.5K | 0.01% | 00.0% | Unchanged |
| UBS Group AG | 17,529 | $23.5K | 0.00% | +17,198+5,195.8% | Added |
| PFG Investments, LLC | 13,979 | $18.7K | 0.00% | +13,979 | New |
| Dimensional Fund Advisors LP | 10,003 | $13.4K | 0.00% | 00.0% | Unchanged |
| National Bank of Canada | 10,000 | $13.4K | 0.00% | +10,000 | New |
| Morgan Stanley | 6,971 | $9.34K | 0.00% | 00.0% | Unchanged |
| Russell Investments Group, Ltd. | 6,400 | $8.58K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 5,654 | $7.58K | 0.00% | +96+1.7% | Added |
| FMR LLC | 3,139 | $4.21K | 0.00% | +250+8.7% | Added |
| CIBC Private Wealth Group, LLC | 2,880 | $3.86K | 0.00% | +2,880 | New |
| WR Wealth Planners, LLC | 2,600 | $3.48K | 0.00% | 00.0% | Unchanged |
| Cullen/Frost Bankers, Inc. | 2,000 | $2.68K | 0.00% | 00.0% | Unchanged |
| Simplex Trading, LLC | 921 | $1.00K | 0.00% | +921 | New |
| JPMorgan Chase & Co | 472 | $632 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 295 | $395 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 269 | $360 | 0.00% | −7−2.5% | Reduced |
| Wells Fargo & Company | 200 | $268 | 0.00% | −800−80.0% | Reduced |
| CoreCap Advisors, LLC | 192 | $257 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $202 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $134 | 0.00% | 00.0% | Unchanged |
| Northwestern Mutual Wealth Management Co | 50 | $67 | 0.00% | +50 | New |
| Federation des caisses Desjardins du Quebec | 30 | $40 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 12 | $16 | 0.00% | 00.0% | Unchanged |
| Murchinson Ltd. | 0 | $0 | 0.00% | −873,910−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −67,728−100.0% | Sold out |
| Texas Yale Capital Corp. | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Royal Bank of Canada | 0 | $0 | 0.00% | −1,959−100.0% | Sold out |
| Allworth Financial LP | 0 | $0 | 0.00% | −600−100.0% | Sold out |
| Rhumbline Advisers | 0 | $0 | 0.00% | −458−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| BlackRock Inc. | – | – | – | – | Not filed |