Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q3 2021
Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 88
- −1 vs. Q2 2021
- Shares held
- 18.4M
- +885.2K (+5.1%) vs. Q2 2021
- Total value
- $338.3M
- +$94.2M (+38.6%) vs. Q2 2021
- New holders
- 6
- 22 more added
- Sold out
- 7
- 26 more reduced
Compare with Q2 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q3 2021
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Investors Research Corp | 50 | $1.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 115 | $2.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $2.00K | 0.00% | +59+115.7% | Added |
| Carroll Financial Associates, Inc. | 110 | $2.00K | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $2.00K | 0.00% | 00.0% | Unchanged |
| Toth Financial Advisory Corp | 172 | $3.00K | 0.00% | 00.0% | Unchanged |
| TCI Wealth Advisors, Inc. | 146 | $3.00K | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $3.44K | 0.00% | 00.0% | Unchanged |
| Laurel Wealth Advisors LLC | 200 | $4.00K | 0.00% | 00.0% | Unchanged |
| C M Bidwell & Associates Ltd | 372 | $7.00K | 0.00% | 00.0% | Unchanged |
| Brewin Dolphin Ltd | 478 | $8.80K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 516 | $9.00K | 0.00% | 00.0% | Unchanged |
| Geneos Wealth Management Inc. | 590 | $10.0K | 0.00% | 00.0% | Unchanged |
| Brewin Dolphin Wealth Management Ltd | 600 | $11.0K | 0.00% | 00.0% | Unchanged |
| Penserra Capital Management LLC | 730 | $13.0K | 0.00% | +55+8.1% | Added |
| Atlas Capital Advisors LLC | 727 | $13.4K | 0.00% | 00.0% | Unchanged |
| US Bancorp | 1,000 | $18.0K | 0.00% | −2,000−66.7% | Reduced |
| Cullen/Frost Bankers, Inc. | 1,000 | $18.0K | 0.00% | 00.0% | Unchanged |
| Steward Partners Investment Advisory, LLC | 1,000 | $18.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 1,007 | $19.0K | 0.00% | −7,377−88.0% | Reduced |
| Cutler Group LP | 1,260 | $23.0K | 0.00% | −800−38.8% | Reduced |
| Ameritas Investment Partners, Inc. | 1,713 | $32.0K | 0.00% | 00.0% | Unchanged |
| Liberty Wealth Management LLC | 2,000 | $37.0K | 0.01% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 2,000 | $37.0K | 0.00% | 00.0% | Unchanged |
| Bollard Group LLC | 2,215 | $41.0K | 0.00% | 00.0% | Unchanged |
| Legal & General Group Plc | 2,467 | $45.0K | 0.00% | −92−3.6% | Reduced |
| Advisor Group Holdings, Inc. | 2,548 | $46.0K | 0.00% | −7,515−74.7% | Reduced |
| Institutional & Family Asset Management, LLC | 2,500 | $46.0K | 0.01% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,553 | $65.0K | 0.00% | +94+2.7% | Added |
| Bedel Financial Consulting, Inc. | 3,837 | $71.0K | 0.02% | 00.0% | Unchanged |
| Patriot Financial Group Insurance Agency, LLC | 4,150 | $76.0K | 0.01% | −600−12.6% | Reduced |
| BNP Paribas Arbitrage, SA | 4,343 | $80.0K | 0.00% | +3,396+358.6% | Added |
| Metropolitan Life Insurance Co | 6,987 | $128.6K | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 7,766 | $144.0K | 0.00% | −32,081−80.5% | Reduced |
| Russell Investments Group, Ltd. | 8,147 | $149.0K | 0.00% | −9,222−53.1% | Reduced |
| Barclays PLC | 9,965 | $183.0K | 0.00% | +4,401+79.1% | Added |
| MetLife Investment Management | 9,977 | $183.7K | 0.00% | 00.0% | Unchanged |
| Radnor Capital Management, LLC | 10,000 | $184.0K | 0.11% | 00.0% | Unchanged |
| Voya Investment Management LLC | 10,124 | $186.0K | 0.00% | 00.0% | Unchanged |
| SG Americas Securities, LLC | 10,617 | $195.0K | 0.00% | +10,617 | New |
| State Board of Administration of Florida Retirement System | 11,007 | $203.0K | 0.00% | 00.0% | Unchanged |
| Parametric Portfolio Associates LLC | 11,308 | $208.0K | 0.00% | −18,639−62.2% | Reduced |
| Alliancebernstein L.P. | 11,934 | $220.0K | 0.00% | −2,300−16.2% | Reduced |
| California State Teachers Retirement System | 13,044 | $240.0K | 0.00% | −20,402−61.0% | Reduced |
| American International Group, Inc. | 13,245 | $244.0K | 0.00% | −314−2.3% | Reduced |
| Bank of America Corp | 13,668 | $251.0K | 0.00% | +5,967+77.5% | Added |
| Manufacturers Life Insurance Company, The | 14,276 | $263.0K | 0.00% | −1,665−10.4% | Reduced |
| Deutsche Bank AG | 14,763 | $272.0K | 0.00% | −452−3.0% | Reduced |
| Citigroup Inc | 16,085 | $296.0K | 0.00% | −23,245−59.1% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $322.0K | 0.01% | 00.0% | Unchanged |
| Rafferty Asset Management, LLC | 18,789 | $346.0K | 0.00% | −5,109−21.4% | Reduced |
| Rhumbline Advisers | 19,590 | $361.0K | 0.00% | +1,025+5.5% | Added |
| Sentinel Pension Advisors Inc | 20,200 | $372.0K | 0.13% | +20,200 | New |
| Campbell & CO Investment Adviser LLC | 23,900 | $440.0K | 0.14% | +23,900 | New |
| Janney Montgomery Scott LLC | 26,000 | $479.0K | 0.00% | +2,500+10.6% | Added |
| UBS Group AG | 28,822 | $530.0K | 0.00% | +26,929+1,422.6% | Added |
| IndexIQ Advisors LLC | 30,543 | $562.0K | 0.02% | +3,059+11.1% | Added |
| Susquehanna International Group, LLP | 39,748 | $732.0K | 0.00% | −1,710−4.1% | Reduced |
| Bourgeon Capital Management LLC | 41,746 | $769.0K | 0.16% | +41,746 | New |
| D.A. Davidson & Co. | 43,000 | $792.0K | 0.01% | +9,000+26.5% | Added |
| Stifel Financial Corp | 47,316 | $871.0K | 0.00% | −1,753−3.6% | Reduced |
| Morgan Stanley | 56,501 | $1.04M | 0.00% | −13,271−19.0% | Reduced |
| Brandywine Global Investment Management, LLC | 58,400 | $1.07M | 0.01% | +58,400 | New |
| Charles Schwab Investment Management Inc | 63,586 | $1.17M | 0.00% | +3,090+5.1% | Added |
| New York State Common Retirement Fund | 71,220 | $1.31M | 0.00% | +21,329+42.8% | Added |
| Letko, Brosseau & Associates Inc | 73,659 | $1.36M | 0.02% | 00.0% | Unchanged |
| Nuveen Asset Management, LLC | 71,121 | $1.36M | 0.00% | +7,079+11.1% | Added |
| Bank of New York Mellon Corp | 74,207 | $1.37M | 0.00% | +7,612+11.4% | Added |
| JPMorgan Chase & Co | 104,934 | $1.93M | 0.00% | −10,922−9.4% | Reduced |
| Williams Jones Wealth Management, LLC. | 105,500 | $1.94M | 0.03% | +105,500 | New |
| Goldman Sachs Group Inc | 137,579 | $2.53M | 0.00% | +1,317+1.0% | Added |
| Royal Bank of Canada | 180,102 | $3.32M | 0.00% | +177,945+8,249.7% | Added |
| Northern Trust Corp | 257,939 | $4.75M | 0.00% | −2,947−1.1% | Reduced |
| Dimensional Fund Advisors LP | 329,633 | $6.07M | 0.00% | −44,810−12.0% | Reduced |
| AWM Investment Company, Inc. | 372,755 | $6.86M | 0.67% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 377,095 | $6.94M | 0.00% | −61,742−14.1% | Reduced |
| Geode Capital Management, LLC | 444,914 | $8.19M | 0.00% | +31,153+7.5% | Added |
| Novo Holdings A/S | 468,902 | $8.63M | 0.45% | 00.0% | Unchanged |
| Artal Group S.A. | 500,000 | $9.21M | 0.23% | 00.0% | Unchanged |
| Granahan Investment Management Inc | 555,614 | $10.2M | 0.19% | +222,975+67.0% | Added |
| State Street Corp | 802,691 | $14.8M | 0.00% | −8,047−1.0% | Reduced |
| Alphabet Inc. | 889,979 | $16.4M | 0.39% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 941,543 | $17.3M | 0.36% | −24,385−2.5% | Reduced |
| Vanguard Group Inc | 1,292,498 | $23.8M | 0.00% | +15,708+1.2% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $25.4M | 8.43% | 00.0% | Unchanged |
| BlackRock Inc. | 1,802,528 | $33.2M | 0.00% | +23,706+1.3% | Added |
| BVF Inc | 1,809,352 | $33.3M | 1.30% | −328,626−15.4% | Reduced |
| Aquilo Capital Management, LLC | 4,563,688 | $84.0M | 19.77% | +734,479+19.2% | Added |
| Summit Global Investments | 0 | $0 | 0.00% | −13,100−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −11,812−100.0% | Sold out |
| ProShare Advisors LLC | 0 | $0 | 0.00% | −11,608−100.0% | Sold out |
| ExodusPoint Capital Management, LP | 0 | $0 | 0.00% | −10,933−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −507−100.0% | Sold out |
| BDO Wealth Advisors, LLC | 0 | $0 | 0.00% | −75−100.0% | Sold out |
| Rockefeller Capital Management L.P. | 0 | $0 | 0.00% | −10−100.0% | Sold out |