Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
Q2 2025 vs. Q1 2025
How the institutions holding Spero Therapeutics, Inc. changed between Q1 2025 and Q2 2025.
All holders in Q2 2025All holders in Q1 2025
| Measure | Q1 2025 | Q2 2025 | Change |
|---|---|---|---|
| Holders | 38 | 44 | +6 |
| Shares | 15.1M | 11.1M | −4.03M (−26.7%) |
| Value | $10.9M | $32.1M | +$21.3M (+195.4%) |
New holders (16)
Institutions that held Spero Therapeutics, Inc. at the end of Q2 2025 but not at the end of Q1 2025.
| Institution | Shares | Value | % of portfolio |
|---|---|---|---|
| Schonfeld Strategic Advisors LLC | 510,834 | $1.48M | 0.01% |
| EAM Investors, LLC | 239,140 | $693.5K | 0.11% |
| Stonepine Capital Management, LLC | 156,888 | $455.0K | 0.45% |
| Ionic Capital Management LLC | 150,000 | $435.0K | 0.49% |
| Susquehanna International Group, LLP | 69,814 | $202.5K | 0.00% |
| XTX Topco Ltd | 34,551 | $100.2K | 0.00% |
| Capital Asset Advisory Services LLC | 32,548 | $94.4K | 0.00% |
| Axxcess Wealth Management, LLC | 32,548 | $94.4K | 0.00% |
| Quadrature Capital Ltd | 31,205 | $90.5K | 0.00% |
| Cubist Systematic Strategies, LLC | 27,140 | $78.7K | 0.00% |
| Invesco Ltd. | 14,968 | $43.4K | 0.00% |
| Group One Trading, L.P. | 8,239 | $23.9K | 0.00% |
| Royal Bank of Canada | 5,739 | $17.0K | 0.00% |
| Raymond James Financial Inc | 3,082 | $8.94K | 0.00% |
| Tower Research Capital LLC (TRC) | 603 | $1.75K | 0.00% |
| Advisor Group Holdings, Inc. | 290 | $841 | 0.00% |
Sold out (10)
Institutions that held Spero Therapeutics, Inc. at the end of Q1 2025 and filed for Q2 2025 without it.
| Institution | Shares, Q1 2025 | Value, Q1 2025 |
|---|---|---|
| Murchinson Ltd. | 873,910 | $629.2K |
| Atlas Venture Life Science Advisors, LLC | 305,255 | $219.8K |
| Mackenzie Financial Corp | 209,031 | $150.5K |
| DAFNA Capital Management LLC | 125,000 | $90.0K |
| Squarepoint Ops LLC | 92,939 | $66.9K |
| Prudential Financial Inc | 56,000 | $40.3K |
| DLK Investment Management, LLC | 29,825 | $21.5K |
| EP Wealth Advisors, LLC | 16,500 | $11.9K |
| FMR LLC | 5,056 | $3.64K |
| CoreCap Advisors, LLC | 50 | $36 |