Skip to main content
Livermore
Livermore
ZHEN

Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

13F holders, Q3 2023

Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
54
−2 vs. Q2 2023
Shares held
14.2M
−176.8K (−1.2%) vs. Q2 2023
Total value
$17.2M
−$3.66M (−17.6%) vs. Q2 2023
New holders
5
12 more added
Sold out
7
14 more reduced

Compare with Q2 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ3 2023: 54 institutions
Q1 2021: 95 institutionsQ2 2021: 89 institutionsQ3 2021: 88 institutionsQ4 2021: 84 institutionsQ1 2022: 100 institutionsQ2 2022: 79 institutionsQ3 2022: 69 institutionsQ4 2022: 60 institutionsQ1 2023: 48 institutionsQ2 2023: 56 institutionsQ3 2023: 54 institutionsQ4 2023: 50 institutionsQ1 2024: 54 institutionsQ2 2024: 48 institutionsQ3 2024: 46 institutionsQ4 2024: 50 institutionsQ1 2025: 38 institutionsQ2 2025: 44 institutionsQ3 2025: 47 institutionsQ4 2025: 56 institutionsQ1 2026: 50 institutionsQ2 2026: 59 institutions
Value heldQ3 2023: $17.2M
Q1 2021: $273.1MQ2 2021: $244.2MQ3 2021: $338.3MQ4 2021: $316.7MQ1 2022: $176.1MQ2 2022: $15.5MQ3 2022: $39.7MQ4 2022: $24.6MQ1 2023: $20.6MQ2 2023: $20.8MQ3 2023: $17.2MQ4 2023: $19.6MQ1 2024: $23.7MQ2 2024: $18.0MQ3 2024: $16.5MQ4 2024: $16.1MQ1 2025: $10.9MQ2 2025: $32.1MQ3 2025: $21.3MQ4 2025: $49.2MQ1 2026: $48.3MQ2 2026: $47.5M
Institutions holding SPRO and their total value by quarter
QuarterHoldersValue
Q2 202659$47.5M
Q1 202650$48.3M
Q4 202556$49.2M
Q3 202547$21.3M
Q2 202544$32.1M
Q1 202538$10.9M
Q4 202450$16.1M
Q3 202446$16.5M
Q2 202448$18.0M
Q1 202454$23.7M
Q4 202350$19.6M
Q3 202354$17.2M
Q2 202356$20.8M
Q1 202348$20.6M
Q4 202260$24.6M
Q3 202269$39.7M
Q2 202279$15.5M
Q1 2022100$176.1M
Q4 202184$316.7M
Q3 202188$338.3M
Q2 202189$244.2M
Q1 202195$273.1M

Institutions, Q3 2023

Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2023.

Institutions holding SPRO in Q3 2023
InstitutionSharesValue% of portfolioChange in sharesAction
Royal Bank of Canada300$00.00%+300New
Qube Research & Technologies Ltd1$10.00%+1New
BNP Paribas Arbitrage, SA12$150.00%+12New
Advisor Group Holdings, Inc.97$1170.00%−2,092−95.6%Reduced
GWM Advisors LLC100$1210.00%00.0%Unchanged
US Bancorp151$1830.00%00.0%Unchanged
Heritage Wealth Advisors187$2260.00%00.0%Unchanged
Beaird Harris Wealth Management, LLC202$2450.00%00.0%Unchanged
JPMorgan Chase & Co236$2860.00%00.0%Unchanged
PFS Partners, LLC250$3030.00%00.0%Unchanged
Rhumbline Advisers458$5540.00%00.0%Unchanged
Wells Fargo & Company515$6230.00%−14−2.6%Reduced
Tower Research Capital LLC (TRC)572$6920.00%+537+1,534.3%Added
Allworth Financial LP600$7260.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec730$8830.00%00.0%Unchanged
Cullen/Frost Bankers, Inc.2,000$2.42K0.00%00.0%Unchanged
WR Wealth Planners, LLC2,600$3.15K0.00%00.0%Unchanged
Russell Investments Group, Ltd.6,400$7.74K0.00%00.0%Unchanged
Bank of America Corp8,782$10.6K0.00%−4,455−33.7%Reduced
Morgan Stanley8,988$10.9K0.00%−542−5.7%Reduced
Texas Yale Capital Corp.10,000$12.1K0.00%00.0%Unchanged
Dimensional Fund Advisors LP11,753$14.2K0.00%00.0%Unchanged
Bourgeon Capital Management LLC15,100$18.3K0.00%00.0%Unchanged
ERn Financial, LLC15,766$19.1K0.00%+15,766New
Mackenzie Financial Corp17,198$20.1K0.00%00.0%Unchanged
Two Sigma Investments, LP17,023$20.6K0.00%−67,512−79.9%Reduced
HRT Financial LP18,627$22.0K0.00%+18,627New
Susquehanna International Group, LLP20,183$24.4K0.00%−24,176−54.5%Reduced
UBS Group AG27,135$32.8K0.00%+64+0.2%Added
Prudential Financial Inc28,200$34.1K0.00%+3,800+15.6%Added
Charles Schwab Investment Management Inc28,565$34.6K0.00%00.0%Unchanged
Group One Trading, L.P.34,190$41.4K0.00%−57,780−62.8%Reduced
Rock Springs Capital Management LP57,373$69.4K0.00%−612,160−91.4%Reduced
XTX Topco Ltd58,368$70.6K0.01%−48,016−45.1%Reduced
Northern Trust Corp88,881$107.5K0.00%+136+0.2%Added
Millennium Management LLC119,694$144.8K0.00%−254,156−68.0%Reduced
DAFNA Capital Management LLC125,000$151.3K0.05%00.0%Unchanged
Squarepoint Ops LLC129,497$156.7K0.00%+51,434+65.9%Added
State Street Corp130,511$157.9K0.00%+19,800+17.9%Added
Bridgeway Capital Management, LLC134,800$163.1K0.00%+25,000+22.8%Added
OUP Management Co., LLC249,070$301.4K0.68%00.0%Unchanged
Acadian Asset Management LLC272,024$327.0K0.00%+98,485+56.8%Added
AWM Investment Company, Inc.333,400$403.4K0.06%−50,000−13.0%Reduced
Geode Capital Management, LLC412,707$499.5K0.00%+21,902+5.6%Added
Ameriprise Financial Inc463,641$561.0K0.00%−4,319−0.9%Reduced
Novo Holdings A/S468,902$567.4K0.04%00.0%Unchanged
BlackRock Inc.481,809$583.0K0.00%−41,995−8.0%Reduced
Renaissance Technologies LLC547,165$662.0K0.00%−46,266−7.8%Reduced
Murchinson Ltd.862,700$1.04M0.16%+100,000+13.1%Added
Alphabet Inc.889,979$1.08M0.07%00.0%Unchanged
Atlas Venture Life Science Advisors, LLC1,013,438$1.23M0.19%00.0%Unchanged
Atlas Venture Associates IX, LLC1,353,303$1.64M13.93%00.0%Unchanged
Vanguard Group Inc1,557,596$1.88M0.00%+31,122+2.0%Added
Anson Funds Management LP4,159,572$5.03M1.67%+714,710+20.7%Added
Royce & Associates LP0$00.00%−22,851−100.0%Sold out
Virtu Financial LLC0$00.00%−22,195−100.0%Sold out
Citadel Advisors LLC0$00.00%−14,956−100.0%Sold out
Federated Hermes, Inc.0$00.00%−2,647−100.0%Sold out
Simplex Trading, LLC0$00.00%−2,281−100.0%Sold out
Investors Research Corp0$00.00%−50−100.0%Sold out
FMR LLC0$00.00%−4−100.0%Sold out