Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q1 2023
Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 48
- −10 vs. Q4 2022
- Shares held
- 14.3M
- +44.6K (+0.3%) vs. Q4 2022
- Total value
- $20.6M
- −$3.97M (−16.2%) vs. Q4 2022
- New holders
- 3
- 15 more added
- Sold out
- 13
- 7 more reduced
2 institutions that held it in Q4 2022 haven't filed for Q1 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q1 2023
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q4 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| JPMorgan Chase & Co | 236 | $0 | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $73 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $145 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $219 | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $271 | 0.00% | 00.0% | Unchanged |
| Beaird Harris Wealth Management, LLC | 202 | $293 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 250 | $358 | 0.00% | 00.0% | Unchanged |
| TD Waterhouse Canada Inc. | 300 | $456 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 511 | $741 | 0.00% | +103+25.2% | Added |
| Allworth Financial LP | 600 | $870 | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 541 | $1.00K | 0.00% | −32,623−98.4% | Reduced |
| Federation des caisses Desjardins du Quebec | 700 | $1.01K | 0.00% | +700 | New |
| Cullen/Frost Bankers, Inc. | 2,000 | $2.90K | 0.00% | 00.0% | Unchanged |
| WR Wealth Planners, LLC | 2,600 | $3.77K | 0.00% | +2,600 | New |
| Advisor Group Holdings, Inc. | 3,124 | $4.86K | 0.00% | +47+1.5% | Added |
| Federated Hermes, Inc. | 4,853 | $7.04K | 0.00% | +4,744+4,352.3% | Added |
| Russell Investments Group, Ltd. | 6,400 | $9.28K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $14.5K | 0.00% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 11,753 | $17.0K | 0.00% | 00.0% | Unchanged |
| Morgan Stanley | 15,230 | $22.1K | 0.00% | −1,847−10.8% | Reduced |
| Bank of America Corp | 18,417 | $26.7K | 0.00% | +10,479+132.0% | Added |
| Invesco Ltd. | 18,979 | $27.5K | 0.00% | +6,906+57.2% | Added |
| Bourgeon Capital Management LLC | 25,600 | $37.1K | 0.01% | +12,500+95.4% | Added |
| Susquehanna International Group, LLP | 26,544 | $38.5K | 0.00% | −24,105−47.6% | Reduced |
| Charles Schwab Investment Management Inc | 28,565 | $41.4K | 0.00% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 32,100 | $46.5K | 0.00% | −7,695−19.3% | Reduced |
| UBS Group AG | 41,523 | $60.2K | 0.00% | −4,159−9.1% | Reduced |
| Marshall Wace, LLP | 64,388 | $93.4K | 0.00% | +13,471+26.5% | Added |
| Northern Trust Corp | 86,256 | $125.1K | 0.00% | +16,672+24.0% | Added |
| Group One Trading, L.P. | 87,104 | $126.3K | 0.01% | +81,363+1,417.2% | Added |
| Bridgeway Capital Management, LLC | 109,800 | $159.2K | 0.00% | +109,800 | New |
| State Street Corp | 110,711 | $160.5K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 119,861 | $173.8K | 0.04% | −226,873−65.4% | Reduced |
| DAFNA Capital Management LLC | 125,000 | $181.3K | 0.05% | 00.0% | Unchanged |
| OUP Management Co., LLC | 249,070 | $361.2K | 0.72% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 337,856 | $489.9K | 0.00% | +80,572+31.3% | Added |
| Renaissance Technologies LLC | 410,300 | $595.0K | 0.00% | +67,400+19.7% | Added |
| Novo Holdings A/S | 468,902 | $679.9K | 0.05% | 00.0% | Unchanged |
| BlackRock Inc. | 489,813 | $710.2K | 0.00% | +1,730+0.4% | Added |
| Millennium Management LLC | 494,541 | $717.0K | 0.00% | −381,857−43.6% | Reduced |
| Rock Springs Capital Management LP | 669,533 | $970.8K | 0.02% | 00.0% | Unchanged |
| Murchinson Ltd. | 805,621 | $1.11M | 0.21% | +42,921+5.6% | Added |
| Alphabet Inc. | 889,979 | $1.29M | 0.07% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $1.50M | 0.20% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 1,300,400 | $1.89M | 0.26% | 00.0% | Unchanged |
| Atlas Venture Associates IX, LLC | 1,376,968 | $2.00M | 9.37% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,426,571 | $2.07M | 0.00% | +372,183+35.3% | Added |
| Anson Funds Management LP | 3,344,862 | $4.85M | 1.53% | +325,254+10.8% | Added |
| Oasis Management Co Ltd. | 0 | $0 | 0.00% | −288,000−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −34,369−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −23,523−100.0% | Sold out |
| CI Private Wealth, LLC | 0 | $0 | 0.00% | −17,500−100.0% | Sold out |
| Prudential Financial Inc | 0 | $0 | 0.00% | −14,600−100.0% | Sold out |
| Sentinel Pension Advisors Inc | 0 | $0 | 0.00% | −12,000−100.0% | Sold out |
| Stifel Financial Corp | 0 | $0 | 0.00% | −10,766−100.0% | Sold out |
| Colony Group LLC | 0 | $0 | 0.00% | −10,000−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −9,206−100.0% | Sold out |
| Belpointe Asset Management LLC | 0 | $0 | 0.00% | −4,560−100.0% | Sold out |
| BNP Paribas Arbitrage, SA | 0 | $0 | 0.00% | −668−100.0% | Sold out |
| Aspire Private Capital, LLC | 0 | $0 | 0.00% | −100−100.0% | Sold out |
| Steward Financial Group LLC | 0 | $0 | 0.00% | −354−100.0% | Sold out |
| Gofen & Glossberg LLC | – | – | – | – | Not filed |
| CoreCap Advisors, LLC | – | – | – | – | Not filed |