Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 59
- +9 vs. Q1 2026
- Shares held
- 21.4M
- +804.5K (+3.9%) vs. Q1 2026
- Total value
- $47.5M
- −$808.9K (−1.7%) vs. Q1 2026
- New holders
- 21
- 16 more added
- Sold out
- 12
- 6 more reduced
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $49.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.5M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $143.1M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $25.5M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $179.6M |
| Q4 2021 | 84 | $318.3M |
| Q3 2021 | 87 | $338.2M |
| Q2 2021 | 88 | $244.1M |
| Q1 2021 | 94 | $273.1M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Farther Finance Advisors, LLC | 10 | $22 | 0.00% | 00.0% | Unchanged |
| SBI Securities Co., Ltd. | 13 | $29 | 0.00% | +4+44.4% | Added |
| US Bancorp | 151 | $334 | 0.00% | 00.0% | Unchanged |
| Rialto Wealth Management, LLC | 172 | $381 | 0.00% | +172 | New |
| Wells Fargo & Company | 200 | $442 | 0.00% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 236 | $533 | 0.00% | 00.0% | Unchanged |
| Advisor Group Holdings, Inc. | 290 | $640 | 0.00% | 00.0% | Unchanged |
| FMR LLC | 300 | $663 | 0.00% | +300 | New |
| Morgan Stanley | 914 | $2.02K | 0.00% | −3,638−79.9% | Reduced |
| Royal Bank of Canada | 2,014 | $4.00K | 0.00% | +2,014 | New |
| Jones Financial Companies LLLP | 7,678 | $17.4K | 0.00% | 00.0% | Unchanged |
| FNY Investment Advisers, LLC | 8,300 | $18.0K | 0.01% | +3,000+56.6% | Added |
| Citigroup Inc | 9,625 | $21.3K | 0.00% | −9,510−49.7% | Reduced |
| Prudential Financial Inc | 10,400 | $23.0K | 0.00% | +10,400 | New |
| Two Sigma Securities, LLC | 10,576 | $23.4K | 0.00% | +10,576 | New |
| Group One Trading, L.P. | 10,869 | $24.0K | 0.00% | +10,869 | New |
| SG Americas Securities, LLC | 11,268 | $25.0K | 0.00% | +11,268 | New |
| Qube Research & Technologies Ltd | 13,644 | $30.2K | 0.00% | +13,644 | New |
| Susquehanna Fundamental Investments, LLC | 16,095 | $35.6K | 0.00% | +16,095 | New |
| Susquehanna Portfolio Strategies, LLC | 17,628 | $39.0K | 0.00% | +17,628 | New |
| DLK Investment Management, LLC | 31,355 | $40.8K | 0.02% | +31,355 | New |
| Assenagon Asset Management S.A. | 18,636 | $41.2K | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 19,298 | $42.6K | 0.00% | +19,298 | New |
| Oppenheimer & Co Inc | 22,850 | $50.5K | 0.00% | +22,850 | New |
| Global Retirement Partners, LLC | 25,000 | $55.3K | 0.00% | +25,000 | New |
| Vanguard Global Advisers, LLC | 25,446 | $56.2K | 0.00% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 28,565 | $63.1K | 0.00% | 00.0% | Unchanged |
| Three Seasons Wealth, LLC | 30,000 | $66.3K | 0.01% | 00.0% | Unchanged |
| Capital Asset Advisory Services LLC | 32,548 | $71.9K | 0.00% | 00.0% | Unchanged |
| Axxcess Wealth Management, LLC | 32,548 | $71.9K | 0.00% | +32,548 | New |
| American Century Companies Inc | 36,811 | $81.4K | 0.00% | +36,811 | New |
| XTX Topco Ltd | 50,536 | $111.7K | 0.00% | +50,536 | New |
| Verdad Advisers, LP | 51,335 | $113.5K | 0.11% | +17,880+53.4% | Added |
| Simplex Trading, LLC | 61,312 | $135.5K | 0.00% | +31,008+102.3% | Added |
| Invesco Ltd. | 64,245 | $142.0K | 0.00% | +18,871+41.6% | Added |
| Shay Capital LLC | 72,391 | $160.0K | 0.02% | +2,037+2.9% | Added |
| Federation des caisses Desjardins du Quebec | 91,900 | $202.2K | 0.00% | +91,900 | New |
| Ionic Capital Management LLC | 102,698 | $227.0K | 0.21% | −93,241−47.6% | Reduced |
| Point72 Asset Management, L.P. | 104,377 | $230.7K | 0.00% | +44,709+74.9% | Added |
| Northern Trust Corp | 108,274 | $239.3K | 0.00% | −12,710−10.5% | Reduced |
| Bridgeway Capital Management, LLC | 114,800 | $253.7K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 139,680 | $308.7K | 0.00% | +136,671+4,542.1% | Added |
| Jane Street Group, LLC | 158,097 | $349.4K | 0.00% | +51,752+48.7% | Added |
| State Street Corp | 214,751 | $474.6K | 0.00% | 00.0% | Unchanged |
| Goldman Sachs Group Inc | 256,985 | $567.9K | 0.00% | +256,985 | New |
| Dimensional Fund Advisors LP | 274,820 | $607.6K | 0.00% | +245,052+823.2% | Added |
| Gsa Capital Partners LLP | 285,906 | $632.0K | 0.04% | +7,602+2.7% | Added |
| Vanguard Fiduciary Trust Co | 287,648 | $635.7K | 0.00% | +23,533+8.9% | Added |
| Arrowstreet Capital, Limited Partnership | 332,970 | $735.9K | 0.00% | +332,970 | New |
| Two Sigma Investments, LP | 382,814 | $846.0K | 0.00% | −502,817−56.8% | Reduced |
| Raymond James Financial Inc | 521,705 | $1.15M | 0.00% | +521,705 | New |
| Geode Capital Management, LLC | 566,329 | $1.25M | 0.00% | +46,407+8.9% | Added |
| BlackRock, Inc. | 594,404 | $1.31M | 0.00% | +161,202+37.2% | Added |
| Susquehanna International Group, LLP | 759,290 | $1.68M | 0.00% | +426,175+127.9% | Added |
| Alphabet Inc. | 889,979 | $1.97M | 0.00% | 00.0% | Unchanged |
| Renaissance Technologies LLC | 947,904 | $2.09M | 0.00% | −241,331−20.3% | Reduced |
| Vanguard Capital Management LLC | 2,036,226 | $4.50M | 0.00% | +236,346+13.1% | Added |
| Pfizer Inc | 2,362,348 | $5.34M | 3.13% | 00.0% | Unchanged |
| GSK plc | 9,190,606 | $20.3M | 3.37% | 00.0% | Unchanged |
| Anson Funds Management LP | 0 | $0 | 0.00% | −421,956−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −376,458−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −194,301−100.0% | Sold out |
| Marshall Wace, LLP | 0 | $0 | 0.00% | −157,072−100.0% | Sold out |
| Quadrature Capital Ltd | 0 | $0 | 0.00% | −40,128−100.0% | Sold out |
| Omers Administration Corp | 0 | $0 | 0.00% | −39,400−100.0% | Sold out |
| Schonfeld Strategic Advisors LLC | 0 | $0 | 0.00% | −20,314−100.0% | Sold out |
| Occudo Quantitative Strategies LP | 0 | $0 | 0.00% | −16,421−100.0% | Sold out |
| Intrepid Family Office LLC | 0 | $0 | 0.00% | −16,279−100.0% | Sold out |
| Torrey Growth & Income Advisors | 0 | $0 | 0.00% | −17,025−100.0% | Sold out |
| BNP Paribas Arbitrage, SA | 0 | $0 | 0.00% | −40−100.0% | Sold out |
| Caitong International Asset Management Co., Ltd | 0 | $0 | 0.00% | −3−100.0% | Sold out |