Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q2 2021
Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2021. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 89
- −6 vs. Q1 2021
- Shares held
- 17.5M
- −1.06M (−5.7%) vs. Q1 2021
- Total value
- $244.2M
- −$28.9M (−10.6%) vs. Q1 2021
- New holders
- 14
- 29 more added
- Sold out
- 20
- 21 more reduced
Compare with Q1 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q2 2021
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Rockefeller Capital Management L.P. | 10 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 51 | $1.00K | 0.00% | 00.0% | Unchanged |
| Carroll Financial Associates, Inc. | 110 | $1.00K | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $1.00K | 0.00% | −10−16.7% | Reduced |
| BDO Wealth Advisors, LLC | 75 | $1.00K | 0.00% | +75 | New |
| Aspire Private Capital, LLC | 100 | $1.00K | 0.00% | +100 | New |
| Toth Financial Advisory Corp | 172 | $2.00K | 0.00% | 00.0% | Unchanged |
| Harbour Investments, Inc. | 115 | $2.00K | 0.00% | 00.0% | Unchanged |
| TCI Wealth Advisors, Inc. | 146 | $2.00K | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $2.61K | 0.00% | +187 | New |
| Laurel Wealth Advisors LLC | 200 | $3.00K | 0.00% | +200 | New |
| C M Bidwell & Associates Ltd | 372 | $5.00K | 0.00% | +372 | New |
| Brewin Dolphin Ltd | 478 | $6.67K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 516 | $7.00K | 0.00% | +223+76.1% | Added |
| Simplex Trading, LLC | 507 | $7.00K | 0.00% | +507 | New |
| Brewin Dolphin Wealth Management Ltd | 600 | $8.38K | 0.00% | 00.0% | Unchanged |
| Geneos Wealth Management Inc. | 590 | $9.00K | 0.00% | −3,611−86.0% | Reduced |
| Penserra Capital Management LLC | 675 | $9.00K | 0.00% | +55+8.9% | Added |
| Atlas Capital Advisors LLC | 727 | $10.1K | 0.00% | +726+72,600.0% | Added |
| BNP Paribas Arbitrage, SA | 947 | $13.2K | 0.00% | −13,382−93.4% | Reduced |
| Steward Partners Investment Advisory, LLC | 1,000 | $14.0K | 0.00% | −1,200−54.5% | Reduced |
| Cullen/Frost Bankers, Inc. | 1,000 | $14.0K | 0.00% | 00.0% | Unchanged |
| Ameritas Investment Partners, Inc. | 1,713 | $24.0K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 1,893 | $27.0K | 0.00% | −29,134−93.9% | Reduced |
| Liberty Wealth Management LLC | 2,000 | $28.0K | 0.01% | 00.0% | Unchanged |
| Banque Cantonale Vaudoise | 2,000 | $28.0K | 0.00% | 00.0% | Unchanged |
| Cutler Group LP | 2,060 | $28.0K | 0.00% | +100+5.1% | Added |
| Royal Bank of Canada | 2,157 | $30.0K | 0.00% | +96+4.7% | Added |
| Bollard Group LLC | 2,215 | $31.0K | 0.00% | 00.0% | Unchanged |
| Institutional & Family Asset Management, LLC | 2,500 | $35.0K | 0.01% | +2,500 | New |
| Legal & General Group Plc | 2,559 | $36.0K | 0.00% | +390+18.0% | Added |
| US Bancorp | 3,000 | $42.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,459 | $48.0K | 0.00% | +164+5.0% | Added |
| Bedel Financial Consulting, Inc. | 3,837 | $54.0K | 0.02% | +3,837 | New |
| Patriot Financial Group Insurance Agency, LLC | 4,750 | $66.0K | 0.01% | +4,750 | New |
| Barclays PLC | 5,564 | $77.0K | 0.00% | −16,076−74.3% | Reduced |
| Metropolitan Life Insurance Co | 6,987 | $97.5K | 0.00% | +1,802+34.8% | Added |
| Bank of America Corp | 7,701 | $107.0K | 0.00% | −11,118−59.1% | Reduced |
| Tower Research Capital LLC (TRC) | 8,384 | $117.0K | 0.00% | +5,238+166.5% | Added |
| MetLife Investment Management | 9,977 | $139.3K | 0.00% | +7,949+392.0% | Added |
| Radnor Capital Management, LLC | 10,000 | $140.0K | 0.05% | 00.0% | Unchanged |
| Voya Investment Management LLC | 10,124 | $141.0K | 0.00% | +10,124 | New |
| Advisor Group Holdings, Inc. | 10,063 | $143.0K | 0.00% | −32,150−76.2% | Reduced |
| ExodusPoint Capital Management, LP | 10,933 | $153.0K | 0.00% | +10,933 | New |
| State Board of Administration of Florida Retirement System | 11,007 | $154.0K | 0.00% | +11,007 | New |
| ProShare Advisors LLC | 11,608 | $162.0K | 0.00% | +11,608 | New |
| Citadel Advisors LLC | 11,812 | $165.0K | 0.00% | −8,268−41.2% | Reduced |
| Summit Global Investments | 13,100 | $183.0K | 0.01% | +13,100 | New |
| American International Group, Inc. | 13,559 | $189.0K | 0.00% | +1,643+13.8% | Added |
| Alliancebernstein L.P. | 14,234 | $199.0K | 0.00% | +3,400+31.4% | Added |
| Deutsche Bank AG | 15,215 | $213.0K | 0.00% | +1,262+9.0% | Added |
| Manufacturers Life Insurance Company, The | 15,941 | $223.0K | 0.00% | +2,484+18.5% | Added |
| Russell Investments Group, Ltd. | 17,369 | $241.0K | 0.00% | −31,798−64.7% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $244.0K | 0.01% | 00.0% | Unchanged |
| Rhumbline Advisers | 18,565 | $259.0K | 0.00% | +126+0.7% | Added |
| Janney Montgomery Scott LLC | 23,500 | $328.0K | 0.00% | +8,500+56.7% | Added |
| Rafferty Asset Management, LLC | 23,898 | $334.0K | 0.00% | −45,065−65.3% | Reduced |
| IndexIQ Advisors LLC | 27,484 | $384.0K | 0.01% | −1,984−6.7% | Reduced |
| Parametric Portfolio Associates LLC | 29,947 | $418.0K | 0.00% | −1,490−4.7% | Reduced |
| California State Teachers Retirement System | 33,446 | $467.0K | 0.00% | +2,523+8.2% | Added |
| D.A. Davidson & Co. | 34,000 | $475.0K | 0.01% | +500+1.5% | Added |
| Citigroup Inc | 39,330 | $549.0K | 0.00% | −46,618−54.2% | Reduced |
| Wells Fargo & Company | 39,847 | $556.0K | 0.00% | +21,927+122.4% | Added |
| Susquehanna International Group, LLP | 41,458 | $579.0K | 0.00% | −27,725−40.1% | Reduced |
| Stifel Financial Corp | 49,069 | $685.0K | 0.00% | +500+1.0% | Added |
| New York State Common Retirement Fund | 49,891 | $696.0K | 0.00% | −8,638−14.8% | Reduced |
| Charles Schwab Investment Management Inc | 60,496 | $845.0K | 0.00% | +7,138+13.4% | Added |
| Nuveen Asset Management, LLC | 64,042 | $894.0K | 0.00% | −308−0.5% | Reduced |
| Bank of New York Mellon Corp | 66,595 | $930.0K | 0.00% | +3,423+5.4% | Added |
| Morgan Stanley | 69,772 | $974.0K | 0.00% | −119,177−63.1% | Reduced |
| Letko, Brosseau & Associates Inc | 73,659 | $1.03M | 0.01% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 115,856 | $1.62M | 0.00% | +47,287+69.0% | Added |
| Goldman Sachs Group Inc | 136,262 | $1.90M | 0.00% | −119,538−46.7% | Reduced |
| Northern Trust Corp | 260,886 | $3.64M | 0.00% | +21,308+8.9% | Added |
| Granahan Investment Management Inc | 332,639 | $4.64M | 0.09% | −9,474−2.8% | Reduced |
| AWM Investment Company, Inc. | 372,755 | $5.20M | 0.51% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 374,443 | $5.23M | 0.00% | +31,937+9.3% | Added |
| Geode Capital Management, LLC | 413,761 | $5.78M | 0.00% | +50,150+13.8% | Added |
| Ameriprise Financial Inc | 438,837 | $6.13M | 0.00% | +4,049+0.9% | Added |
| Novo Holdings A/S | 468,902 | $6.55M | 0.29% | 00.0% | Unchanged |
| Artal Group S.A. | 500,000 | $6.98M | 0.16% | 00.0% | Unchanged |
| State Street Corp | 810,738 | $11.3M | 0.00% | −545,805−40.2% | Reduced |
| Alphabet Inc. | 889,979 | $12.4M | 0.25% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 965,928 | $13.5M | 0.27% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,276,790 | $17.8M | 0.00% | +170,094+15.4% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $19.2M | 3.38% | 00.0% | Unchanged |
| BlackRock Inc. | 1,778,822 | $24.8M | 0.00% | +2,226+0.1% | Added |
| BVF Inc | 2,137,978 | $29.8M | 1.12% | 00.0% | Unchanged |
| Aquilo Capital Management, LLC | 3,829,209 | $53.5M | 13.89% | 00.0% | Unchanged |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −181,578−100.0% | Sold out |
| Alyeska Investment Group, L.P. | 0 | $0 | 0.00% | −49,602−100.0% | Sold out |
| California Public Employees Retirement System | 0 | $0 | 0.00% | −30,600−100.0% | Sold out |
| Sentinel Pension Advisors Inc | 0 | $0 | 0.00% | −26,410−100.0% | Sold out |
| Los Angeles Capital Management LLC | 0 | $0 | 0.00% | −27,960−100.0% | Sold out |
| Qube Research & Technologies Ltd | 0 | $0 | 0.00% | −24,878−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −24,528−100.0% | Sold out |
| State of Wisconsin Investment Board | 0 | $0 | 0.00% | −20,700−100.0% | Sold out |
| Vontobel Holding Ltd. | 0 | $0 | 0.00% | −13,865−100.0% | Sold out |
| Millennium Management LLC | 0 | $0 | 0.00% | −12,635−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −11,496−100.0% | Sold out |