Spero Therapeutics, Inc.

SPRO

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001701108

SEC filings (opens in a new tab)

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

Q2 2022 vs. Q1 2022

How the institutions holding Spero Therapeutics, Inc. changed between Q1 2022 and Q2 2022.

All holders in Q2 2022 All holders in Q1 2022

13F holders of SPRO: Q1 2022 compared with Q2 2022
Measure	Q1 2022	Of which not filed for Q2 2022	Q2 2022	Change
Holders	100	2	79	−19
Shares	20.2M	48.1K	21.0M	+765.5K (+3.8%)
Value	$176.1M	$418.0K	$15.5M	−$160.1M (−91.2%)

2 institutions that held it in Q1 2022 haven't filed for Q2 2022 yet. Not filing isn't selling, so the changes leave them out.

New holders (16)

Institutions that held Spero Therapeutics, Inc. at the end of Q2 2022 but not at the end of Q1 2022.

Institutions new to SPRO in Q2 2022
Institution	Shares	Value	% of portfolio
Oasis Management Co Ltd.	288,000	$213.0K	0.04%
AQR Capital Management LLC	155,474	$115.0K	0.00%
Ergoteles LLC	102,408	$76.0K	0.00%
Acadian Asset Management LLC	94,977	$70.0K	0.00%
Kingsbury Capital Investment Advisors LLC	60,844	$45.0K	0.06%
Group One Trading, L.P.	24,244	$18.0K	0.00%
Diametric Capital, LP	20,700	$15.0K	0.01%
Qube Research & Technologies Ltd	17,664	$13.0K	0.00%
Boothbay Fund Management, LLC	12,853	$10.0K	0.00%
LMR Partners LLP	11,508	$9.00K	0.00%
Prelude Capital Management, LLC	10,726	$8.00K	0.00%
Dynamic Technology Lab Private Ltd	10,664	$8.00K	0.00%
Federated Hermes, Inc.	2,579	$2.00K	0.00%
Credit Suisse AG	13	$0	0.00%
Allworth Financial LP	102	$0	0.00%
CoreCap Advisors, LLC	142	$0	0.00%

Sold out (35)

Institutions that held Spero Therapeutics, Inc. at the end of Q1 2022 and filed for Q2 2022 without it.

Institutions that sold out of SPRO in Q2 2022
Institution	Shares, Q1 2022	Value, Q1 2022
Ameriprise Financial Inc	586,642	$5.10M
AWM Investment Company, Inc.	372,755	$3.24M
Royal Bank of Canada	196,097	$1.71M
Granahan Investment Management Inc	113,322	$986.0K
Charles Schwab Investment Management Inc	65,547	$571.0K
Eversept Partners, LP	59,639	$518.9K
Nuveen Asset Management, LLC	60,598	$516.0K
Walleye Capital LLC	40,009	$348.0K
State of Wisconsin Investment Board	31,600	$275.0K
Janney Montgomery Scott LLC	25,500	$222.0K
Rhumbline Advisers	24,740	$215.0K
Trexquant Investment LP	24,151	$210.0K
Jane Street Group, LLC	15,622	$136.0K
Cubist Systematic Strategies, LLC	14,144	$123.0K
Deutsche Bank AG	13,885	$121.0K
XTX Topco Ltd	13,260	$115.0K
Alliancebernstein L.P.	12,934	$113.0K
American International Group, Inc.	12,015	$105.0K
Manufacturers Life Insurance Company, The	11,620	$101.1K
HRT Financial LP	11,277	$98.0K
State Board of Administration of Florida Retirement System	11,007	$96.0K
Engineers Gate Manager LP	10,957	$95.0K
California State Teachers Retirement System	10,256	$89.0K
Radnor Capital Management, LLC	10,000	$87.0K
Allspring Global Investments Holdings, LLC	9,048	$78.0K
Amalgamated Bank	3,887	$34.0K
Bedel Financial Consulting, Inc.	3,837	$33.0K
Bollard Group LLC	2,215	$19.0K
Ameritas Investment Partners, Inc.	1,713	$15.0K
Patriot Financial Group Insurance Agency, LLC	1,200	$10.0K
Atlas Capital Advisors LLC	727	$6.33K
TCWP LLC	425	$3.00K
Laurel Wealth Advisors LLC	200	$2.00K
Toth Financial Advisory Corp	172	$1.00K
Quadrant Capital Group LLC	106	$1.00K

Not filed for Q2 2022 yet (2)

Institutions that held Spero Therapeutics, Inc. at the end of Q1 2022 and haven't filed a 13F for Q2 2022. Not filing isn't selling, so they aren't counted as sold out.

Institutions holding SPRO in Q1 2022 that haven't filed for Q2 2022
Institution	Shares, Q1 2022	Value, Q1 2022
Parametric Portfolio Associates LLC	44,168	$384.0K
Amalgamated Financial Corp.	3,887	$34.0K