Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q1 2022
Institutional positions in Spero Therapeutics, Inc. as of Mar 31, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 100
- +17 vs. Q4 2021
- Shares held
- 20.2M
- +451.6K (+2.3%) vs. Q4 2021
- Total value
- $176.1M
- −$140.6M (−44.4%) vs. Q4 2021
- New holders
- 25
- 15 more added
- Sold out
- 8
- 23 more reduced
1 institution that held it in Q4 2021 haven't filed for Q1 2022 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2021: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q1 2022
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q4 2021.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Investors Research Corp | 50 | $0 | 0.00% | 00.0% | Unchanged |
| Toth Financial Advisory Corp | 172 | $1.00K | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $1.00K | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $1.00K | 0.00% | 00.0% | Unchanged |
| FMR LLC | 103 | $1.00K | 0.00% | +103 | New |
| Quadrant Capital Group LLC | 106 | $1.00K | 0.00% | +106 | New |
| Beaird Harris Wealth Management, LLC | 282 | $2.00K | 0.00% | 00.0% | Unchanged |
| Heritage Wealth Advisors | 187 | $2.00K | 0.00% | 00.0% | Unchanged |
| Laurel Wealth Advisors LLC | 200 | $2.00K | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 250 | $2.17K | 0.00% | 00.0% | Unchanged |
| Steward Financial Group LLC | 354 | $3.00K | 0.00% | 00.0% | Unchanged |
| TCWP LLC | 425 | $3.00K | 0.00% | +425 | New |
| TD Waterhouse Canada Inc. | 500 | $3.54K | 0.00% | 00.0% | Unchanged |
| Captrust Financial Advisors | 516 | $4.00K | 0.00% | 00.0% | Unchanged |
| Atlas Capital Advisors LLC | 727 | $6.33K | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 755 | $7.00K | 0.00% | −32,327−97.7% | Reduced |
| Cullen/Frost Bankers, Inc. | 1,000 | $9.00K | 0.00% | 00.0% | Unchanged |
| Patriot Financial Group Insurance Agency, LLC | 1,200 | $10.0K | 0.00% | −2,950−71.1% | Reduced |
| US Bancorp | 1,151 | $10.0K | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 1,581 | $14.0K | 0.00% | −31,323−95.2% | Reduced |
| Ameritas Investment Partners, Inc. | 1,713 | $15.0K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,950 | $17.0K | 0.00% | −1,276−39.6% | Reduced |
| Banque Cantonale Vaudoise | 2,000 | $17.0K | 0.00% | 00.0% | Unchanged |
| Bollard Group LLC | 2,215 | $19.0K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 2,508 | $21.8K | 0.00% | −6,489−72.1% | Reduced |
| Legal & General Group Plc | 2,581 | $22.0K | 0.00% | +114+4.6% | Added |
| Bedel Financial Consulting, Inc. | 3,837 | $33.0K | 0.01% | 00.0% | Unchanged |
| Amalgamated Bank | 3,887 | $34.0K | 0.00% | +3,887 | New |
| Amalgamated Financial Corp. | 3,887 | $34.0K | 0.00% | +3,887 | New |
| Barclays PLC | 3,930 | $35.0K | 0.00% | −25,441−86.6% | Reduced |
| Simplex Trading, LLC | 6,346 | $55.0K | 0.00% | +6,346 | New |
| Russell Investments Group, Ltd. | 7,250 | $63.0K | 0.00% | 00.0% | Unchanged |
| Allspring Global Investments Holdings, LLC | 9,048 | $78.0K | 0.00% | −1,138−11.2% | Reduced |
| Bank of America Corp | 9,810 | $85.0K | 0.00% | −31,843−76.4% | Reduced |
| Radnor Capital Management, LLC | 10,000 | $87.0K | 0.02% | 00.0% | Unchanged |
| California State Teachers Retirement System | 10,256 | $89.0K | 0.00% | −2,482−19.5% | Reduced |
| Citadel Advisors LLC | 10,797 | $94.0K | 0.00% | +10,797 | New |
| Engineers Gate Manager LP | 10,957 | $95.0K | 0.00% | +10,957 | New |
| State Board of Administration of Florida Retirement System | 11,007 | $96.0K | 0.00% | 00.0% | Unchanged |
| HRT Financial LP | 11,277 | $98.0K | 0.00% | +11,277 | New |
| Manufacturers Life Insurance Company, The | 11,620 | $101.1K | 0.00% | −2,436−17.3% | Reduced |
| American International Group, Inc. | 12,015 | $105.0K | 0.00% | −845−6.6% | Reduced |
| Tower Research Capital LLC (TRC) | 12,423 | $108.0K | 0.00% | +3,655+41.7% | Added |
| Alliancebernstein L.P. | 12,934 | $113.0K | 0.00% | 00.0% | Unchanged |
| XTX Topco Ltd | 13,260 | $115.0K | 0.05% | +13,260 | New |
| Deutsche Bank AG | 13,885 | $121.0K | 0.00% | −1,658−10.7% | Reduced |
| Cubist Systematic Strategies, LLC | 14,144 | $123.0K | 0.00% | +14,144 | New |
| Wells Fargo & Company | 14,283 | $124.0K | 0.00% | −8,411−37.1% | Reduced |
| Jane Street Group, LLC | 15,622 | $136.0K | 0.00% | +15,622 | New |
| Two Sigma Advisers, LP | 16,400 | $143.0K | 0.00% | +16,400 | New |
| New York State Common Retirement Fund | 17,123 | $149.0K | 0.00% | −36,605−68.1% | Reduced |
| Gofen & Glossberg LLC | 17,500 | $152.0K | 0.00% | 00.0% | Unchanged |
| D. E. Shaw & Co., Inc. | 18,646 | $162.0K | 0.00% | +18,646 | New |
| Assenagon Asset Management S.A. | 23,123 | $201.0K | 0.00% | +23,123 | New |
| Trexquant Investment LP | 24,151 | $210.0K | 0.01% | +24,151 | New |
| Rhumbline Advisers | 24,740 | $215.0K | 0.00% | +5,479+28.4% | Added |
| Janney Montgomery Scott LLC | 25,500 | $222.0K | 0.00% | 00.0% | Unchanged |
| Gsa Capital Partners LLP | 25,916 | $225.0K | 0.03% | +25,916 | New |
| Williams Jones Wealth Management, LLC. | 26,000 | $226.0K | 0.00% | −49,000−65.3% | Reduced |
| Marshall Wace, LLP | 26,027 | $227.0K | 0.00% | +26,027 | New |
| State of Wisconsin Investment Board | 31,600 | $275.0K | 0.00% | 00.0% | Unchanged |
| Stifel Financial Corp | 37,728 | $328.0K | 0.00% | +7,842+26.2% | Added |
| Walleye Capital LLC | 40,009 | $348.0K | 0.01% | +40,009 | New |
| Sentinel Pension Advisors Inc | 42,000 | $365.0K | 0.12% | +11,800+39.1% | Added |
| D.A. Davidson & Co. | 43,800 | $381.0K | 0.00% | 00.0% | Unchanged |
| Parametric Portfolio Associates LLC | 44,168 | $384.0K | 0.00% | +44,168 | New |
| Nuveen Asset Management, LLC | 60,598 | $516.0K | 0.00% | 00.0% | Unchanged |
| Eversept Partners, LP | 59,639 | $518.9K | 0.05% | +59,639 | New |
| Millennium Management LLC | 61,261 | $533.0K | 0.00% | +61,261 | New |
| Bourgeon Capital Management LLC | 63,096 | $549.0K | 0.12% | +11,850+23.1% | Added |
| Charles Schwab Investment Management Inc | 65,547 | $571.0K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 67,084 | $584.0K | 0.00% | −8,099−10.8% | Reduced |
| Knoll Capital Management, LLC | 70,000 | $609.0K | 0.38% | +70,000 | New |
| Morgan Stanley | 72,996 | $635.0K | 0.00% | +22,511+44.6% | Added |
| Bank of New York Mellon Corp | 73,070 | $636.0K | 0.00% | −1,930−2.6% | Reduced |
| Letko, Brosseau & Associates Inc | 73,659 | $641.0K | 0.01% | 00.0% | Unchanged |
| Two Sigma Investments, LP | 78,908 | $686.0K | 0.00% | +78,908 | New |
| JPMorgan Chase & Co | 81,172 | $706.0K | 0.00% | −16,013−16.5% | Reduced |
| Renaissance Technologies LLC | 109,100 | $949.0K | 0.00% | +109,100 | New |
| Granahan Investment Management Inc | 113,322 | $986.0K | 0.02% | −265,610−70.1% | Reduced |
| Goldman Sachs Group Inc | 141,426 | $1.23M | 0.00% | +2,815+2.0% | Added |
| Royal Bank of Canada | 196,097 | $1.71M | 0.00% | +13,502+7.4% | Added |
| Northern Trust Corp | 238,452 | $2.07M | 0.00% | −14,748−5.8% | Reduced |
| OUP Management Co., LLC | 249,070 | $2.17M | 1.65% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 372,755 | $3.24M | 0.42% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 406,946 | $3.54M | 0.00% | +35,724+9.6% | Added |
| Novo Holdings A/S | 468,902 | $4.08M | 0.22% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 471,189 | $4.10M | 0.00% | +14,005+3.1% | Added |
| State Street Corp | 497,185 | $4.33M | 0.00% | −346,770−41.1% | Reduced |
| Artal Group S.A. | 500,000 | $4.35M | 0.18% | 00.0% | Unchanged |
| Ameriprise Financial Inc | 586,642 | $5.10M | 0.00% | +223,108+61.4% | Added |
| Alphabet Inc. | 889,979 | $7.74M | 0.25% | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 990,913 | $8.62M | 0.22% | +45,600+4.8% | Added |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $8.97M | 1.13% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,373,928 | $12.0M | 0.00% | +22,550+1.7% | Added |
| Atlas Venture Associates IX, LLC | 1,376,968 | $12.0M | 11.02% | 00.0% | Unchanged |
| BVF Inc | 1,585,615 | $13.8M | 0.55% | 00.0% | Unchanged |
| BlackRock Inc. | 1,794,081 | $15.6M | 0.00% | −4,696−0.3% | Reduced |
| Aquilo Capital Management, LLC | 5,281,504 | $45.9M | 13.41% | +317,323+6.4% | Added |
| Advisor Group Holdings, Inc. | 1,095 | – | – | −30−2.7% | Reduced |