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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

13F holders, Q2 2023

Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
56
+8 vs. Q1 2023
Shares held
14.4M
+112.9K (+0.8%) vs. Q1 2023
Total value
$20.8M
+$223.6K (+1.1%) vs. Q1 2023
New holders
11
11 more added
Sold out
3
13 more reduced

Compare with Q1 2023: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2023: 56 institutions
Q1 2021: 95 institutionsQ2 2021: 89 institutionsQ3 2021: 88 institutionsQ4 2021: 84 institutionsQ1 2022: 100 institutionsQ2 2022: 79 institutionsQ3 2022: 69 institutionsQ4 2022: 60 institutionsQ1 2023: 48 institutionsQ2 2023: 56 institutionsQ3 2023: 54 institutionsQ4 2023: 50 institutionsQ1 2024: 54 institutionsQ2 2024: 48 institutionsQ3 2024: 46 institutionsQ4 2024: 50 institutionsQ1 2025: 38 institutionsQ2 2025: 44 institutionsQ3 2025: 47 institutionsQ4 2025: 56 institutionsQ1 2026: 50 institutionsQ2 2026: 59 institutions
Value heldQ2 2023: $20.8M
Q1 2021: $273.1MQ2 2021: $244.2MQ3 2021: $338.3MQ4 2021: $316.7MQ1 2022: $176.1MQ2 2022: $15.5MQ3 2022: $39.7MQ4 2022: $24.6MQ1 2023: $20.6MQ2 2023: $20.8MQ3 2023: $17.2MQ4 2023: $19.6MQ1 2024: $23.7MQ2 2024: $18.0MQ3 2024: $16.5MQ4 2024: $16.1MQ1 2025: $10.9MQ2 2025: $32.1MQ3 2025: $21.3MQ4 2025: $49.2MQ1 2026: $48.3MQ2 2026: $47.5M
Institutions holding SPRO and their total value by quarter
QuarterHoldersValue
Q2 202659$47.5M
Q1 202650$48.3M
Q4 202556$49.2M
Q3 202547$21.3M
Q2 202544$32.1M
Q1 202538$10.9M
Q4 202450$16.1M
Q3 202446$16.5M
Q2 202448$18.0M
Q1 202454$23.7M
Q4 202350$19.6M
Q3 202354$17.2M
Q2 202356$20.8M
Q1 202348$20.6M
Q4 202260$24.6M
Q3 202269$39.7M
Q2 202279$15.5M
Q1 2022100$176.1M
Q4 202184$316.7M
Q3 202188$338.3M
Q2 202189$244.2M
Q1 202195$273.1M

Institutions, Q2 2023

Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2023.

Institutions holding SPRO in Q2 2023
InstitutionSharesValue% of portfolioChange in sharesAction
FMR LLC4$60.00%+4New
Tower Research Capital LLC (TRC)35$510.00%−506−93.5%Reduced
Investors Research Corp50$730.00%00.0%Unchanged
GWM Advisors LLC100$1450.00%00.0%Unchanged
US Bancorp151$2190.00%00.0%Unchanged
Heritage Wealth Advisors187$2710.00%00.0%Unchanged
Beaird Harris Wealth Management, LLC202$2930.00%00.0%Unchanged
JPMorgan Chase & Co236$3420.00%00.0%Unchanged
PFS Partners, LLC250$3580.00%00.0%Unchanged
Rhumbline Advisers458$6640.00%+458New
Wells Fargo & Company529$7670.00%+18+3.5%Added
Allworth Financial LP600$8700.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec730$1.06K0.00%+30+4.3%Added
Cullen/Frost Bankers, Inc.2,000$2.90K0.00%00.0%Unchanged
Simplex Trading, LLC2,281$3.00K0.00%+2,281New
Advisor Group Holdings, Inc.2,189$3.26K0.00%−935−29.9%Reduced
WR Wealth Planners, LLC2,600$3.77K0.00%00.0%Unchanged
Federated Hermes, Inc.2,647$3.84K0.00%−2,206−45.5%Reduced
Russell Investments Group, Ltd.6,400$9.28K0.00%00.0%Unchanged
Morgan Stanley9,530$13.8K0.00%−5,700−37.4%Reduced
Texas Yale Capital Corp.10,000$14.5K0.00%00.0%Unchanged
Dimensional Fund Advisors LP11,753$17.0K0.00%00.0%Unchanged
Bank of America Corp13,237$19.2K0.00%−5,180−28.1%Reduced
Citadel Advisors LLC14,956$21.7K0.00%+14,956New
Bourgeon Capital Management LLC15,100$21.9K0.01%−10,500−41.0%Reduced
Mackenzie Financial Corp17,198$25.3K0.00%+17,198New
Virtu Financial LLC22,195$32.0K0.00%+22,195New
Royce & Associates LP22,851$33.1K0.00%+22,851New
Prudential Financial Inc24,400$35.4K0.00%+24,400New
UBS Group AG27,071$39.3K0.00%−14,452−34.8%Reduced
Charles Schwab Investment Management Inc28,565$41.4K0.00%00.0%Unchanged
Susquehanna International Group, LLP44,359$64.3K0.00%+17,815+67.1%Added
Squarepoint Ops LLC78,063$113.2K0.00%+78,063New
Two Sigma Investments, LP84,535$122.6K0.00%+52,435+163.3%Added
Northern Trust Corp88,745$128.7K0.00%+2,489+2.9%Added
Group One Trading, L.P.91,970$133.4K0.01%+4,866+5.6%Added
XTX Topco Ltd106,384$154.3K0.03%−13,477−11.2%Reduced
Bridgeway Capital Management, LLC109,800$159.2K0.00%00.0%Unchanged
State Street Corp110,711$160.5K0.00%00.0%Unchanged
DAFNA Capital Management LLC125,000$181.3K0.05%00.0%Unchanged
Acadian Asset Management LLC173,539$250.0K0.00%+173,539New
OUP Management Co., LLC249,070$361.2K0.62%00.0%Unchanged
Millennium Management LLC373,850$542.1K0.00%−120,691−24.4%Reduced
AWM Investment Company, Inc.383,400$555.9K0.08%−917,000−70.5%Reduced
Geode Capital Management, LLC390,805$566.7K0.00%+52,949+15.7%Added
Ameriprise Financial Inc467,960$678.5K0.00%+467,960New
Novo Holdings A/S468,902$679.9K0.05%00.0%Unchanged
BlackRock Inc.523,804$759.5K0.00%+33,991+6.9%Added
Renaissance Technologies LLC593,431$860.0K0.00%+183,131+44.6%Added
Rock Springs Capital Management LP669,533$970.8K0.02%00.0%Unchanged
Murchinson Ltd.762,700$1.11M0.14%−42,921−5.3%Reduced
Alphabet Inc.889,979$1.29M0.07%00.0%Unchanged
Atlas Venture Life Science Advisors, LLC1,013,438$1.47M0.18%−17,722−1.7%Reduced
Atlas Venture Associates IX, LLC1,353,303$1.96M10.74%−23,665−1.7%Reduced
Vanguard Group Inc1,526,474$2.21M0.00%+99,903+7.0%Added
Anson Funds Management LP3,444,862$5.00M1.50%+100,000+3.0%Added
Marshall Wace, LLP0$00.00%−64,388−100.0%Sold out
Invesco Ltd.0$00.00%−18,979−100.0%Sold out
TD Waterhouse Canada Inc.0$00.00%−300−100.0%Sold out