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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

13F holders, Q2 2024

Institutional positions in Spero Therapeutics, Inc. as of Jun 30, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
48
−6 vs. Q1 2024
Shares held
13.9M
+120.0K (+0.9%) vs. Q1 2024
Total value
$18.0M
−$5.63M (−23.8%) vs. Q1 2024
New holders
5
12 more added
Sold out
11
8 more reduced

Compare with Q1 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2024: 48 institutions
Q1 2021: 95 institutionsQ2 2021: 89 institutionsQ3 2021: 88 institutionsQ4 2021: 84 institutionsQ1 2022: 100 institutionsQ2 2022: 79 institutionsQ3 2022: 69 institutionsQ4 2022: 60 institutionsQ1 2023: 48 institutionsQ2 2023: 56 institutionsQ3 2023: 54 institutionsQ4 2023: 50 institutionsQ1 2024: 54 institutionsQ2 2024: 48 institutionsQ3 2024: 46 institutionsQ4 2024: 50 institutionsQ1 2025: 38 institutionsQ2 2025: 44 institutionsQ3 2025: 47 institutionsQ4 2025: 56 institutionsQ1 2026: 50 institutionsQ2 2026: 59 institutions
Value heldQ2 2024: $18.0M
Q1 2021: $273.1MQ2 2021: $244.2MQ3 2021: $338.3MQ4 2021: $316.7MQ1 2022: $176.1MQ2 2022: $15.5MQ3 2022: $39.7MQ4 2022: $24.6MQ1 2023: $20.6MQ2 2023: $20.8MQ3 2023: $17.2MQ4 2023: $19.6MQ1 2024: $23.7MQ2 2024: $18.0MQ3 2024: $16.5MQ4 2024: $16.1MQ1 2025: $10.9MQ2 2025: $32.1MQ3 2025: $21.3MQ4 2025: $49.2MQ1 2026: $48.3MQ2 2026: $47.5M
Institutions holding SPRO and their total value by quarter
QuarterHoldersValue
Q2 202659$47.5M
Q1 202650$48.3M
Q4 202556$49.2M
Q3 202547$21.3M
Q2 202544$32.1M
Q1 202538$10.9M
Q4 202450$16.1M
Q3 202446$16.5M
Q2 202448$18.0M
Q1 202454$23.7M
Q4 202350$19.6M
Q3 202354$17.2M
Q2 202356$20.8M
Q1 202348$20.6M
Q4 202260$24.6M
Q3 202269$39.7M
Q2 202279$15.5M
Q1 2022100$176.1M
Q4 202184$316.7M
Q3 202188$338.3M
Q2 202189$244.2M
Q1 202195$273.1M

Institutions, Q2 2024

Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q1 2024.

Institutions holding SPRO in Q2 2024
InstitutionSharesValue% of portfolioChange in sharesAction
Qube Research & Technologies Ltd1$10.00%00.0%Unchanged
BNP Paribas Arbitrage, SA12$160.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec30$390.00%00.0%Unchanged
GWM Advisors LLC100$1300.00%00.0%Unchanged
US Bancorp151$1960.00%00.0%Unchanged
CoreCap Advisors, LLC192$2500.00%+50+35.2%Added
JPMorgan Chase & Co236$3070.00%00.0%Unchanged
Tower Research Capital LLC (TRC)276$3590.00%+60+27.8%Added
Advisor Group Holdings, Inc.295$3840.00%+248+527.7%Added
UBS Group AG331$4300.00%−5,397−94.2%Reduced
Rhumbline Advisers458$5950.00%00.0%Unchanged
Allworth Financial LP600$8400.00%00.0%Unchanged
Wells Fargo & Company1,000$1.30K0.00%+460+85.2%Added
Cullen/Frost Bankers, Inc.2,000$2.60K0.00%+2,000New
Royal Bank of Canada1,959$3.00K0.00%+1,959New
WR Wealth Planners, LLC2,600$3.38K0.00%00.0%Unchanged
FMR LLC2,889$3.76K0.00%+500+20.9%Added
Bank of America Corp5,558$7.22K0.00%+366+7.0%Added
Russell Investments Group, Ltd.6,400$8.32K0.00%00.0%Unchanged
Morgan Stanley6,971$9.06K0.00%−928−11.7%Reduced
Texas Yale Capital Corp.10,000$13.0K0.00%00.0%Unchanged
Dimensional Fund Advisors LP10,003$13.0K0.00%00.0%Unchanged
Three Seasons Wealth, LLC15,000$19.5K0.01%00.0%Unchanged
Susquehanna International Group, LLP23,073$30.0K0.00%+23,073New
Shay Capital LLC25,000$32.5K0.01%−281,967−91.9%Reduced
Charles Schwab Investment Management Inc28,565$37.1K0.00%00.0%Unchanged
DLK Investment Management, LLC31,355$40.8K0.02%00.0%Unchanged
Mackenzie Financial Corp32,729$42.5K0.00%+4,287+15.1%Added
Two Sigma Securities, LLC67,728$88.0K0.00%+67,728New
Man Group plc73,469$95.5K0.00%−140,557−65.7%Reduced
Millennium Management LLC98,518$128.1K0.00%−49,354−33.4%Reduced
Northern Trust Corp112,303$146.0K0.00%−2,256−2.0%Reduced
DAFNA Capital Management LLC125,000$162.5K0.04%00.0%Unchanged
State Street Corp130,511$169.7K0.00%00.0%Unchanged
Bridgeway Capital Management, LLC184,800$240.2K0.01%00.0%Unchanged
Citadel Advisors LLC312,034$405.6K0.00%+312,034New
AWM Investment Company, Inc.333,400$433.4K0.06%00.0%Unchanged
Novo Holdings A/S468,902$609.6K0.03%00.0%Unchanged
BlackRock Inc.483,402$628.4K0.00%+6,506+1.4%Added
Geode Capital Management, LLC492,187$640.0K0.00%+22,746+4.8%Added
Atlas Venture Life Science Advisors, LLC535,336$695.9K0.07%−72,277−11.9%Reduced
Murchinson Ltd.873,910$1.14M0.24%00.0%Unchanged
Alphabet Inc.889,979$1.16M0.06%00.0%Unchanged
ADAR1 Capital Management, LLC918,929$1.19M0.24%−8,000−0.9%Reduced
Renaissance Technologies LLC975,952$1.27M0.00%+121,492+14.2%Added
Acadian Asset Management LLC1,071,860$1.39M0.00%+309,262+40.6%Added
Vanguard Group Inc1,770,525$2.30M0.00%+117,093+7.1%Added
Anson Funds Management LP3,750,450$4.88M0.74%00.0%Unchanged
Bank of Montreal0$00.00%−79,500−100.0%Sold out
Squarepoint Ops LLC0$00.00%−79,401−100.0%Sold out
Bailard, Inc.0$00.00%−60,900−100.0%Sold out
Gsa Capital Partners LLP0$00.00%−28,319−100.0%Sold out
Prudential Financial Inc0$00.00%−25,400−100.0%Sold out
Virtu Financial LLC0$00.00%−18,180−100.0%Sold out
XTX Topco Ltd0$00.00%−15,013−100.0%Sold out
Lazard Asset Management LLC0$00.00%−1,248−100.0%Sold out
IFP Advisors, Inc0$00.00%−650−100.0%Sold out
Raleigh Capital Management Inc.0$00.00%−500−100.0%Sold out
PFS Partners, LLC0$00.00%−50−100.0%Sold out