Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q4 2023
Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2023. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 50
- −2 vs. Q3 2023
- Shares held
- 13.8M
- +1.25M (+9.9%) vs. Q3 2023
- Total value
- $19.6M
- +$4.42M (+29.1%) vs. Q3 2023
- New holders
- 6
- 10 more added
- Sold out
- 8
- 10 more reduced
2 institutions that held it in Q3 2023 haven't filed for Q4 2023 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2023: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q4 2023
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2023.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Royal Bank of Canada | 315 | $0 | 0.00% | +15+5.0% | Added |
| Tower Research Capital LLC (TRC) | 1 | $1 | 0.00% | −571−99.8% | Reduced |
| Qube Research & Technologies Ltd | 1 | $1 | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 12 | $18 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 50 | $74 | 0.00% | −200−80.0% | Reduced |
| Advisor Group Holdings, Inc. | 97 | $143 | 0.00% | 00.0% | Unchanged |
| GWM Advisors LLC | 100 | $147 | 0.00% | 00.0% | Unchanged |
| US Bancorp | 151 | $222 | 0.00% | 00.0% | Unchanged |
| FMR LLC | 189 | $278 | 0.00% | +189 | New |
| JPMorgan Chase & Co | 236 | $347 | 0.00% | 00.0% | Unchanged |
| UBS Group AG | 329 | $484 | 0.00% | −26,806−98.8% | Reduced |
| Rhumbline Advisers | 458 | $673 | 0.00% | 00.0% | Unchanged |
| Wells Fargo & Company | 533 | $784 | 0.00% | +18+3.5% | Added |
| Allworth Financial LP | 600 | $882 | 0.00% | 00.0% | Unchanged |
| Federation des caisses Desjardins du Quebec | 730 | $1.07K | 0.00% | 00.0% | Unchanged |
| Group One Trading, L.P. | 4,590 | $6.75K | 0.00% | −29,600−86.6% | Reduced |
| Bank of America Corp | 5,750 | $8.45K | 0.00% | −3,032−34.5% | Reduced |
| Russell Investments Group, Ltd. | 6,400 | $9.41K | 0.00% | 00.0% | Unchanged |
| Texas Yale Capital Corp. | 10,000 | $14.7K | 0.00% | 00.0% | Unchanged |
| Dimensional Fund Advisors LP | 10,003 | $14.7K | 0.00% | −1,750−14.9% | Reduced |
| Two Sigma Securities, LLC | 10,301 | $15.1K | 0.00% | +10,301 | New |
| Morgan Stanley | 12,035 | $17.7K | 0.00% | +3,047+33.9% | Added |
| Three Seasons Wealth, LLC | 15,000 | $22.1K | 0.02% | +15,000 | New |
| Bourgeon Capital Management LLC | 15,100 | $22.2K | 0.00% | 00.0% | Unchanged |
| Susquehanna International Group, LLP | 18,086 | $26.6K | 0.00% | −2,097−10.4% | Reduced |
| Mackenzie Financial Corp | 21,462 | $31.5K | 0.00% | +4,264+24.8% | Added |
| Prudential Financial Inc | 28,200 | $41.5K | 0.00% | 00.0% | Unchanged |
| Charles Schwab Investment Management Inc | 28,565 | $42.0K | 0.00% | 00.0% | Unchanged |
| DLK Investment Management, LLC | 31,355 | $46.1K | 0.02% | +31,355 | New |
| Citadel Advisors LLC | 32,274 | $47.4K | 0.00% | +32,274 | New |
| XTX Topco Ltd | 65,966 | $97.0K | 0.02% | +7,598+13.0% | Added |
| Northern Trust Corp | 88,881 | $130.7K | 0.00% | 00.0% | Unchanged |
| Squarepoint Ops LLC | 122,802 | $180.5K | 0.00% | −6,695−5.2% | Reduced |
| DAFNA Capital Management LLC | 125,000 | $183.8K | 0.04% | 00.0% | Unchanged |
| State Street Corp | 130,511 | $191.9K | 0.00% | 00.0% | Unchanged |
| Bridgeway Capital Management, LLC | 134,800 | $198.2K | 0.00% | 00.0% | Unchanged |
| Millennium Management LLC | 148,857 | $218.8K | 0.00% | +29,163+24.4% | Added |
| AWM Investment Company, Inc. | 333,400 | $490.1K | 0.06% | 00.0% | Unchanged |
| Acadian Asset Management LLC | 343,856 | $505.0K | 0.00% | +71,832+26.4% | Added |
| Ameriprise Financial Inc | 402,963 | $592.4K | 0.00% | −60,678−13.1% | Reduced |
| Geode Capital Management, LLC | 412,707 | $606.8K | 0.00% | 00.0% | Unchanged |
| BlackRock Inc. | 480,599 | $706.5K | 0.00% | −1,210−0.3% | Reduced |
| Renaissance Technologies LLC | 547,465 | $805.0K | 0.00% | +300+0.1% | Added |
| Murchinson Ltd. | 862,700 | $1.27M | 0.24% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $1.31M | 0.06% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 1,013,438 | $1.49M | 0.18% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 1,067,711 | $1.57M | 0.70% | +1,067,711 | New |
| Vanguard Group Inc | 1,643,757 | $2.42M | 0.00% | +86,161+5.5% | Added |
| Anson Funds Management LP | 4,297,699 | $6.32M | 1.31% | +138,127+3.3% | Added |
| Novo Holdings A/S | 468,902 | – | – | 00.0% | Unchanged |
| Rock Springs Capital Management LP | 0 | $0 | 0.00% | −57,373−100.0% | Sold out |
| HRT Financial LP | 0 | $0 | 0.00% | −18,627−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −17,023−100.0% | Sold out |
| ERn Financial, LLC | 0 | $0 | 0.00% | −15,766−100.0% | Sold out |
| WR Wealth Planners, LLC | 0 | $0 | 0.00% | −2,600−100.0% | Sold out |
| Cullen/Frost Bankers, Inc. | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Beaird Harris Wealth Management, LLC | 0 | $0 | 0.00% | −202−100.0% | Sold out |
| Heritage Wealth Advisors | 0 | $0 | 0.00% | −187−100.0% | Sold out |
| Atlas Venture Associates IX, LLC | – | – | – | – | Not filed |
| OUP Management Co., LLC | – | – | – | – | Not filed |