Spero Therapeutics, Inc.
SPRO- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001701108
No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.
13F holders, Q3 2022
Institutional positions in Spero Therapeutics, Inc. as of Sep 30, 2022. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 69
- −10 vs. Q2 2022
- Shares held
- 19.9M
- −1.11M (−5.3%) vs. Q2 2022
- Total value
- $39.7M
- +$24.2M (+155.8%) vs. Q2 2022
- New holders
- 14
- 11 more added
- Sold out
- 24
- 20 more reduced
Compare with Q2 2022: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 59 | $47.5M |
| Q1 2026 | 50 | $48.3M |
| Q4 2025 | 56 | $49.2M |
| Q3 2025 | 47 | $21.3M |
| Q2 2025 | 44 | $32.1M |
| Q1 2025 | 38 | $10.9M |
| Q4 2024 | 50 | $16.1M |
| Q3 2024 | 46 | $16.5M |
| Q2 2024 | 48 | $18.0M |
| Q1 2024 | 54 | $23.7M |
| Q4 2023 | 50 | $19.6M |
| Q3 2023 | 54 | $17.2M |
| Q2 2023 | 56 | $20.8M |
| Q1 2023 | 48 | $20.6M |
| Q4 2022 | 60 | $24.6M |
| Q3 2022 | 69 | $39.7M |
| Q2 2022 | 79 | $15.5M |
| Q1 2022 | 100 | $176.1M |
| Q4 2021 | 84 | $316.7M |
| Q3 2021 | 88 | $338.3M |
| Q2 2021 | 89 | $244.2M |
| Q1 2021 | 95 | $273.1M |
Institutions, Q3 2022
Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q2 2022.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Wells Fargo & Company | 403 | $0 | 0.00% | −488−54.8% | Reduced |
| US Bancorp | 151 | $0 | 0.00% | 00.0% | Unchanged |
| Daiwa Securities Group Inc. | 110 | $0 | 0.00% | 00.0% | Unchanged |
| Investors Research Corp | 50 | $0 | 0.00% | 00.0% | Unchanged |
| Aspire Private Capital, LLC | 100 | $0 | 0.00% | 00.0% | Unchanged |
| Royal Bank of Canada | 43 | $0 | 0.00% | +43 | New |
| Heritage Wealth Advisors | 187 | $374 | 0.00% | 00.0% | Unchanged |
| PFS Partners, LLC | 250 | $500 | 0.00% | 00.0% | Unchanged |
| Citigroup Inc | 495 | $1.00K | 0.00% | −13,867−96.6% | Reduced |
| TD Waterhouse Canada Inc. | 500 | $1.00K | 0.00% | 00.0% | Unchanged |
| Allworth Financial LP | 600 | $1.00K | 0.00% | +498+488.2% | Added |
| Beaird Harris Wealth Management, LLC | 282 | $1.00K | 0.00% | 00.0% | Unchanged |
| Crewe Advisors LLC | 258 | $1.00K | 0.00% | +258 | New |
| China Universal Asset Management Co., Ltd. | 329 | $1.00K | 0.00% | +329 | New |
| BNP Paribas Arbitrage, SA | 522 | $1.04K | 0.00% | −26,654−98.1% | Reduced |
| Atlas Capital Advisors LLC | 727 | $1.45K | 0.00% | +727 | New |
| Simplex Trading, LLC | 1,000 | $2.00K | 0.00% | −8,300−89.2% | Reduced |
| JPMorgan Chase & Co | 1,588 | $3.00K | 0.00% | +313+24.5% | Added |
| Federated Hermes, Inc. | 1,952 | $4.00K | 0.00% | −627−24.3% | Reduced |
| Cullen/Frost Bankers, Inc. | 2,000 | $4.00K | 0.00% | 00.0% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,950 | $4.00K | 0.00% | 00.0% | Unchanged |
| Quantbot Technologies LP | 2,900 | $5.00K | 0.00% | +2,900 | New |
| Russell Investments Group, Ltd. | 6,400 | $12.0K | 0.00% | 00.0% | Unchanged |
| Bank of America Corp | 9,781 | $19.0K | 0.00% | −8,794−47.3% | Reduced |
| Dimensional Fund Advisors LP | 10,003 | $20.0K | 0.00% | −274,953−96.5% | Reduced |
| Man Group plc | 11,184 | $22.0K | 0.00% | +11,184 | New |
| LMR Partners LLP | 11,508 | $23.0K | 0.00% | 00.0% | Unchanged |
| Sentinel Pension Advisors Inc | 12,000 | $24.0K | 0.01% | −30,000−71.4% | Reduced |
| Stifel Financial Corp | 12,506 | $25.0K | 0.00% | −13,722−52.3% | Reduced |
| Weitzel Financial Services, Inc. | 14,200 | $28.4K | 0.02% | +14,200 | New |
| Jane Street Group, LLC | 15,496 | $31.0K | 0.00% | +15,496 | New |
| Qube Research & Technologies Ltd | 15,948 | $32.0K | 0.00% | −1,716−9.7% | Reduced |
| Squarepoint Ops LLC | 16,423 | $33.0K | 0.00% | +16,423 | New |
| Gofen & Glossberg LLC | 17,500 | $35.0K | 0.00% | 00.0% | Unchanged |
| Tower Research Capital LLC (TRC) | 18,239 | $37.0K | 0.00% | −6,838−27.3% | Reduced |
| Morgan Stanley | 19,254 | $38.0K | 0.00% | −175,177−90.1% | Reduced |
| Williams Jones Wealth Management, LLC. | 19,000 | $38.0K | 0.00% | 00.0% | Unchanged |
| Bourgeon Capital Management LLC | 20,600 | $41.0K | 0.01% | +3,000+17.0% | Added |
| UBS Group AG | 22,908 | $46.0K | 0.00% | +22,153+2,934.2% | Added |
| Advisor Group Holdings, Inc. | 24,817 | $50.0K | 0.00% | +22,022+787.9% | Added |
| Group One Trading, L.P. | 55,100 | $110.0K | 0.00% | +30,856+127.3% | Added |
| Goldman Sachs Group Inc | 55,438 | $111.0K | 0.00% | −247,763−81.7% | Reduced |
| Acadian Asset Management LLC | 61,152 | $121.0K | 0.00% | −33,825−35.6% | Reduced |
| Susquehanna International Group, LLP | 69,286 | $139.0K | 0.00% | +15,141+28.0% | Added |
| Northern Trust Corp | 69,963 | $140.0K | 0.00% | −50.0% | Reduced |
| Letko, Brosseau & Associates Inc | 73,659 | $147.0K | 0.00% | 00.0% | Unchanged |
| State Street Corp | 91,311 | $183.0K | 0.00% | −9,073−9.0% | Reduced |
| DAFNA Capital Management LLC | 125,000 | $250.0K | 0.07% | +125,000 | New |
| AQR Capital Management LLC | 186,682 | $373.0K | 0.00% | +31,208+20.1% | Added |
| Marshall Wace, LLP | 186,570 | $374.0K | 0.00% | +150,201+413.0% | Added |
| Bank of Montreal | 202,300 | $415.0K | 0.00% | +202,300 | New |
| Renaissance Technologies LLC | 214,700 | $429.0K | 0.00% | −724,317−77.1% | Reduced |
| OUP Management Co., LLC | 249,070 | $498.0K | 0.78% | 00.0% | Unchanged |
| Oasis Management Co Ltd. | 288,000 | $576.0K | 0.10% | 00.0% | Unchanged |
| Geode Capital Management, LLC | 290,258 | $580.0K | 0.00% | 00.0% | Unchanged |
| Novo Holdings A/S | 468,902 | $938.0K | 0.05% | 00.0% | Unchanged |
| Artal Group S.A. | 500,000 | $1.00M | 0.05% | 00.0% | Unchanged |
| Millennium Management LLC | 688,396 | $1.38M | 0.00% | +373,753+118.8% | Added |
| BlackRock Inc. | 692,138 | $1.39M | 0.00% | +1,385+0.2% | Added |
| Murchinson Ltd. | 762,700 | $1.52M | 0.44% | +762,700 | New |
| Rock Springs Capital Management LP | 770,710 | $1.54M | 0.04% | 00.0% | Unchanged |
| Alphabet Inc. | 889,979 | $1.78M | 0.09% | 00.0% | Unchanged |
| Atlas Venture Life Science Advisors, LLC | 1,031,160 | $2.06M | 0.23% | 00.0% | Unchanged |
| Vanguard Group Inc | 1,053,723 | $2.11M | 0.00% | −192,269−15.4% | Reduced |
| Atlas Venture Associates IX, LLC | 1,376,968 | $2.75M | 8.16% | 00.0% | Unchanged |
| Anson Funds Management LP | 1,473,872 | $2.95M | 0.57% | +1,473,872 | New |
| BVF Inc | 1,929,376 | $3.86M | 0.16% | −1,160,239−37.6% | Reduced |
| AWM Investment Company, Inc. | 2,300,400 | $4.60M | 0.70% | +2,300,400 | New |
| Aquilo Capital Management, LLC | 3,403,210 | $6.81M | 2.86% | −1,918,021−36.0% | Reduced |
| D. E. Shaw & Co., Inc. | 0 | $0 | 0.00% | −649,334−100.0% | Sold out |
| Two Sigma Investments, LP | 0 | $0 | 0.00% | −437,280−100.0% | Sold out |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −176,157−100.0% | Sold out |
| Assenagon Asset Management S.A. | 0 | $0 | 0.00% | −131,020−100.0% | Sold out |
| Citadel Advisors LLC | 0 | $0 | 0.00% | −108,351−100.0% | Sold out |
| Ergoteles LLC | 0 | $0 | 0.00% | −102,408−100.0% | Sold out |
| Knoll Capital Management, LLC | 0 | $0 | 0.00% | −70,000−100.0% | Sold out |
| Kingsbury Capital Investment Advisors LLC | 0 | $0 | 0.00% | −60,844−100.0% | Sold out |
| Diametric Capital, LP | 0 | $0 | 0.00% | −20,700−100.0% | Sold out |
| Bank of New York Mellon Corp | 0 | $0 | 0.00% | −14,966−100.0% | Sold out |
| Boothbay Fund Management, LLC | 0 | $0 | 0.00% | −12,853−100.0% | Sold out |
| D.A. Davidson & Co. | 0 | $0 | 0.00% | −10,800−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −10,450−100.0% | Sold out |
| Prelude Capital Management, LLC | 0 | $0 | 0.00% | −10,726−100.0% | Sold out |
| Dynamic Technology Lab Private Ltd | 0 | $0 | 0.00% | −10,664−100.0% | Sold out |
| FMR LLC | 0 | $0 | 0.00% | −4,120−100.0% | Sold out |
| Legal & General Group Plc | 0 | $0 | 0.00% | −1,934−100.0% | Sold out |
| Banque Cantonale Vaudoise | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Barclays PLC | 0 | $0 | 0.00% | −204−100.0% | Sold out |
| New York State Common Retirement Fund | 0 | $0 | 0.00% | −223−100.0% | Sold out |
| Credit Suisse AG | 0 | $0 | 0.00% | −13−100.0% | Sold out |
| Captrust Financial Advisors | 0 | $0 | 0.00% | −473−100.0% | Sold out |
| CoreCap Advisors, LLC | 0 | $0 | 0.00% | −142−100.0% | Sold out |
| Steward Financial Group LLC | 0 | $0 | 0.00% | −354−100.0% | Sold out |