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Spero Therapeutics, Inc.

SPRO
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001701108

No open-market purchases or sales by Spero Therapeutics, Inc. insiders were filed in the last 90 days; 59 institutions reported holding it in 13F filings for Q2 2026, worth $47.5M in total; no superinvestor holds it.

13F holders, Q4 2024

Institutional positions in Spero Therapeutics, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
50
+4 vs. Q3 2024
Shares held
15.7M
+3.34M (+27.0%) vs. Q3 2024
Total value
$16.1M
−$390.7K (−2.4%) vs. Q3 2024
New holders
12
13 more added
Sold out
8
9 more reduced

Compare with Q3 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting SPRO on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2024: 50 institutions
Q1 2021: 95 institutionsQ2 2021: 89 institutionsQ3 2021: 88 institutionsQ4 2021: 84 institutionsQ1 2022: 100 institutionsQ2 2022: 79 institutionsQ3 2022: 69 institutionsQ4 2022: 60 institutionsQ1 2023: 48 institutionsQ2 2023: 56 institutionsQ3 2023: 54 institutionsQ4 2023: 50 institutionsQ1 2024: 54 institutionsQ2 2024: 48 institutionsQ3 2024: 46 institutionsQ4 2024: 50 institutionsQ1 2025: 38 institutionsQ2 2025: 44 institutionsQ3 2025: 47 institutionsQ4 2025: 56 institutionsQ1 2026: 50 institutionsQ2 2026: 59 institutions
Value heldQ4 2024: $16.1M
Q1 2021: $273.1MQ2 2021: $244.2MQ3 2021: $338.3MQ4 2021: $316.7MQ1 2022: $176.1MQ2 2022: $15.5MQ3 2022: $39.7MQ4 2022: $24.6MQ1 2023: $20.6MQ2 2023: $20.8MQ3 2023: $17.2MQ4 2023: $19.6MQ1 2024: $23.7MQ2 2024: $18.0MQ3 2024: $16.5MQ4 2024: $16.1MQ1 2025: $10.9MQ2 2025: $32.1MQ3 2025: $21.3MQ4 2025: $49.2MQ1 2026: $48.3MQ2 2026: $47.5M
Institutions holding SPRO and their total value by quarter
QuarterHoldersValue
Q2 202659$47.5M
Q1 202650$48.3M
Q4 202556$49.2M
Q3 202547$21.3M
Q2 202544$32.1M
Q1 202538$10.9M
Q4 202450$16.1M
Q3 202446$16.5M
Q2 202448$18.0M
Q1 202454$23.7M
Q4 202350$19.6M
Q3 202354$17.2M
Q2 202356$20.8M
Q1 202348$20.6M
Q4 202260$24.6M
Q3 202269$39.7M
Q2 202279$15.5M
Q1 2022100$176.1M
Q4 202184$316.7M
Q3 202188$338.3M
Q2 202189$244.2M
Q1 202195$273.1M

Institutions, Q4 2024

Shares, value and share of portfolio for each institution holding Spero Therapeutics, Inc.; share changes are against Q3 2024.

Institutions holding SPRO in Q4 2024
InstitutionSharesValue% of portfolioChange in sharesAction
BNP Paribas Arbitrage, SA12$120.00%00.0%Unchanged
Federation des caisses Desjardins du Quebec30$310.00%00.0%Unchanged
CoreCap Advisors, LLC50$520.00%−142−74.0%Reduced
GWM Advisors LLC100$1030.00%00.0%Unchanged
UBS Group AG141$1450.00%−17,388−99.2%Reduced
Richards, Merrill & Peterson, Inc.150$1550.00%+150New
Wells Fargo & Company200$2060.00%00.0%Unchanged
SBI Securities Co., Ltd.213$2190.00%+213New
Advisor Group Holdings, Inc.295$3040.00%00.0%Unchanged
Tower Research Capital LLC (TRC)929$9570.00%+660+245.4%Added
Cullen/Frost Bankers, Inc.2,000$2.06K0.00%00.0%Unchanged
WR Wealth Planners, LLC2,600$2.68K0.00%00.0%Unchanged
FMR LLC4,289$4.42K0.00%+1,150+36.6%Added
Simplex Trading, LLC5,110$5.00K0.00%+4,189+454.8%Added
US Bancorp5,151$5.31K0.00%+5,000+3,311.3%Added
Bank of America Corp5,547$5.71K0.00%−107−1.9%Reduced
Morgan Stanley6,971$7.18K0.00%00.0%Unchanged
National Bank of Canada10,000$10.3K0.00%00.0%Unchanged
Texas Yale Capital Corp.10,000$10.3K0.00%+10,000New
Dimensional Fund Advisors LP10,003$10.3K0.00%00.0%Unchanged
HRT Financial LP14,692$15.0K0.00%+14,692New
PFG Investments, LLC24,534$25.3K0.00%+10,555+75.5%Added
Charles Schwab Investment Management Inc28,565$29.4K0.00%00.0%Unchanged
DLK Investment Management, LLC28,955$29.8K0.01%−2,400−7.7%Reduced
Susquehanna International Group, LLP29,755$30.6K0.00%−14,464−32.7%Reduced
Three Seasons Wealth, LLC30,000$30.9K0.02%00.0%Unchanged
XTX Topco Ltd30,138$31.0K0.00%+30,138New
Virtu Financial LLC46,046$47.0K0.00%+46,046New
Prudential Financial Inc49,200$50.7K0.00%+49,200New
Jane Street Group, LLC52,869$54.5K0.00%+52,869New
Squarepoint Ops LLC55,051$56.7K0.00%+55,051New
JPMorgan Chase & Co61,624$63.5K0.00%+61,388+26,011.9%Added
Northern Trust Corp86,447$89.0K0.00%−25,050−22.5%Reduced
DAFNA Capital Management LLC125,000$128.8K0.03%00.0%Unchanged
State Street Corp148,911$153.4K0.00%+18,400+14.1%Added
Citadel Advisors LLC172,872$178.1K0.00%+91,447+112.3%Added
Bridgeway Capital Management, LLC184,800$190.3K0.00%00.0%Unchanged
Mackenzie Financial Corp187,559$193.2K0.00%+155,656+487.9%Added
Atlas Venture Life Science Advisors, LLC305,255$314.4K0.04%−97,630−24.2%Reduced
Monimus Capital Management, LP310,908$320.2K0.30%+310,908New
Geode Capital Management, LLC481,128$495.7K0.00%−590.0%Reduced
BlackRock, Inc.485,352$499.9K0.00%+532+0.1%Added
ADAR1 Capital Management, LLC801,277$825.3K0.17%+57,818+7.8%Added
Murchinson Ltd.873,910$900.1K0.41%+873,910New
Alphabet Inc.889,979$916.7K0.05%00.0%Unchanged
Acadian Asset Management LLC1,039,922$1.07M0.00%−31,938−3.0%Reduced
Renaissance Technologies LLC1,105,591$1.14M0.00%+130,938+13.4%Added
Vanguard Group Inc1,763,620$1.82M0.00%00.0%Unchanged
Pfizer Inc2,362,348$2.43M0.09%+2,362,348New
Anson Funds Management LP3,839,886$3.96M0.49%+89,436+2.4%Added
Novo Holdings A/S0$00.00%−468,902−100.0%Sold out
AWM Investment Company, Inc.0$00.00%−333,400−100.0%Sold out
Man Group plc0$00.00%−38,481−100.0%Sold out
Millennium Management LLC0$00.00%−32,172−100.0%Sold out
Shay Capital LLC0$00.00%−25,000−100.0%Sold out
Russell Investments Group, Ltd.0$00.00%−6,400−100.0%Sold out
CIBC Private Wealth Group, LLC0$00.00%−2,880−100.0%Sold out
Northwestern Mutual Wealth Management Co0$00.00%−50−100.0%Sold out