Spruce Biosciences, Inc.
SPRB- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001683553
No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.
13F holders, Q2 2026
Institutional positions in Spruce Biosciences, Inc. as of Jun 30, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 65
- +33 vs. Q1 2026
- Shares held
- 2.15M
- +1.41M (+191.0%) vs. Q1 2026
- Total value
- $116.3M
- +$67.9M (+140.5%) vs. Q1 2026
- New holders
- 37
- 16 more added
- Sold out
- 4
- 3 more reduced
Compare with Q1 2026: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting SPRB on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 65 | $116.3M |
| Q1 2026 | 32 | $48.3M |
| Q4 2025 | 32 | $65.6M |
| Q3 2025 | 9 | $25.1M |
| Q2 2025 | 3 | $146.6K |
| Q1 2025 | 31 | $3.03M |
| Q4 2024 | 31 | $4.69M |
| Q3 2024 | 30 | $6.41M |
| Q2 2024 | 38 | $8.61M |
| Q1 2024 | 50 | $14.1M |
| Q4 2023 | 40 | $94.4M |
| Q3 2023 | 41 | $72.0M |
| Q2 2023 | 39 | $68.7M |
| Q1 2023 | 44 | $74.5M |
| Q4 2022 | 31 | $20.0M |
| Q3 2022 | 36 | $24.7M |
| Q2 2022 | 38 | $28.5M |
| Q1 2022 | 43 | $34.4M |
| Q4 2021 | 50 | $79.0M |
| Q3 2021 | 44 | $118.1M |
| Q2 2021 | 41 | $225.3M |
| Q1 2021 | 40 | $313.2M |
Institutions, Q2 2026
Shares, value and share of portfolio for each institution holding Spruce Biosciences, Inc.; share changes are against Q1 2026.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Cassaday & Co Wealth Management LLC | 2 | $108 | 0.00% | 00.0% | Unchanged |
| Friedenthal Financial | 7 | $378 | 0.00% | +7 | New |
| Caldwell Sutter Capital, Inc. | 13 | $702 | 0.00% | 00.0% | Unchanged |
| Jones Financial Companies LLLP | 30 | $1.65K | 0.00% | −163−84.5% | Reduced |
| Sterling Capital Management LLC | 43 | $2.32K | 0.00% | +43 | New |
| Royal Bank of Canada | 166 | $8.00K | 0.00% | +166 | New |
| SBI Securities Co., Ltd. | 201 | $10.9K | 0.00% | +201 | New |
| Russell Investments Group, Ltd. | 217 | $11.7K | 0.00% | +217 | New |
| Tower Research Capital LLC (TRC) | 246 | $13.3K | 0.00% | +106+75.7% | Added |
| Ameritas Investment Partners, Inc. | 247 | $13.3K | 0.00% | +247 | New |
| Legal & General Group Plc | 264 | $14.2K | 0.00% | +264 | New |
| FMR LLC | 343 | $18.5K | 0.00% | +343 | New |
| Vanguard Global Advisers, LLC | 452 | $24.4K | 0.00% | 00.0% | Unchanged |
| BNP Paribas Arbitrage, SA | 453 | $24.5K | 0.00% | +453 | New |
| Barclays PLC | 674 | $36.4K | 0.00% | +674 | New |
| Police & Firemen's Retirement System of New Jersey | 864 | $46.7K | 0.00% | +864 | New |
| Lion Point Capital, LP | 1,000 | $54.0K | 0.26% | 00.0% | Unchanged |
| JPMorgan Chase & Co | 1,127 | $63.0K | 0.00% | +1,127 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 1,252 | $67.6K | 0.00% | +1,252 | New |
| Citigroup Inc | 1,265 | $68.3K | 0.00% | +326+34.7% | Added |
| New York State Common Retirement Fund | 1,900 | $102.6K | 0.00% | +1,900 | New |
| Wells Fargo & Company | 2,329 | $125.8K | 0.00% | +2,329 | New |
| Deutsche Bank AG | 2,652 | $143.2K | 0.00% | +2,652 | New |
| SkyView Investment Advisors, LLC | 3,000 | $162.0K | 0.13% | +3,000 | New |
| Rhumbline Advisers | 3,519 | $190.0K | 0.00% | +3,519 | New |
| Pale Fire Capital SE | 3,818 | $206.2K | 0.01% | +3,818 | New |
| Morgan Stanley | 4,411 | $238.2K | 0.00% | +2,996+211.7% | Added |
| Renaissance Technologies LLC | 4,700 | $253.8K | 0.00% | +4,700 | New |
| Charles Schwab Investment Management Inc | 5,896 | $318.4K | 0.00% | +5,896 | New |
| Bank of New York Mellon Corp | 6,779 | $366.1K | 0.00% | +6,779 | New |
| State Board of Administration of Florida Retirement System | 7,182 | $387.8K | 0.00% | +7,182 | New |
| Persistent Asset Partners Ltd | 7,677 | $414.6K | 0.13% | +5,149+203.7% | Added |
| Dimensional Fund Advisors LP | 8,813 | $476.6K | 0.00% | +8,813 | New |
| Balyasny Asset Management LLC | 12,138 | $655.5K | 0.00% | −27,862−69.7% | Reduced |
| Vanguard Fiduciary Trust Co | 18,361 | $991.5K | 0.00% | +12,847+233.0% | Added |
| Vanguard Portfolio Management LLC | 18,496 | $998.8K | 0.00% | +18,496 | New |
| Ameriprise Financial Inc | 18,834 | $1.02M | 0.00% | +18,834 | New |
| Rosalind Advisors, Inc. | 20,000 | $1.08M | 0.41% | +20,000 | New |
| Knott David M Jr | 20,000 | $1.08M | 0.57% | +20,000 | New |
| Northern Trust Corp | 21,083 | $1.14M | 0.00% | +21,083 | New |
| ExodusPoint Capital Management, LP | 22,000 | $1.19M | 0.01% | 00.0% | Unchanged |
| UBS Group AG | 23,381 | $1.26M | 0.00% | +19,462+496.6% | Added |
| Quinn Opportunity Partners LLC | 26,810 | $1.45M | 0.07% | 00.0% | Unchanged |
| Point72 Asset Management, L.P. | 28,278 | $1.53M | 0.00% | +28,278 | New |
| Stonepine Capital Management, LLC | 28,795 | $1.55M | 1.18% | +28,795 | New |
| Diadema Partners LP | 30,000 | $1.62M | 0.57% | +20,000+200.0% | Added |
| Affinity Asset Advisors, LLC | 30,000 | $1.62M | 0.08% | +30,000 | New |
| Goldman Sachs Group Inc | 32,348 | $1.75M | 0.00% | +26,842+487.5% | Added |
| Carlyle Group Inc. | 38,620 | $2.09M | 0.02% | 00.0% | Unchanged |
| Eversept Partners, LP | 40,000 | $2.16M | 0.12% | +40,000 | New |
| StemPoint Capital LP | 41,388 | $2.23M | 0.39% | +35,028+550.8% | Added |
| Boothbay Fund Management, LLC | 42,080 | $2.27M | 0.04% | 00.0% | Unchanged |
| State Street Corp | 50,450 | $2.72M | 0.00% | +45,050+834.3% | Added |
| Citadel Advisors LLC | 51,905 | $2.80M | 0.00% | −18,094−25.8% | Reduced |
| Cable Car Capital LLC | 60,000 | $3.24M | 0.07% | +60,000 | New |
| ADAR1 Capital Management, LLC | 67,717 | $3.66M | 0.17% | +9,117+15.6% | Added |
| Geode Capital Management, LLC | 70,548 | $3.81M | 0.00% | +57,659+447.4% | Added |
| Alyeska Investment Group, L.P. | 81,671 | $4.41M | 0.01% | +30,000+58.1% | Added |
| Vanguard Capital Management LLC | 119,331 | $6.44M | 0.00% | +100,994+550.8% | Added |
| Ikarian Capital, LLC | 121,356 | $6.55M | 1.07% | 00.0% | Unchanged |
| AWM Investment Company, Inc. | 146,988 | $7.94M | 0.69% | +146,988 | New |
| Millennium Management LLC | 160,981 | $8.69M | 0.01% | +49,093+43.9% | Added |
| BlackRock, Inc. | 187,836 | $10.1M | 0.00% | +170,898+1,009.0% | Added |
| OrbiMed Advisors LLC | 200,000 | $10.8M | 0.20% | +200,000 | New |
| AIGH Capital Management LLC | 250,000 | $13.5M | 1.22% | +250,000 | New |
| Wellington Management Group LLP | 0 | $0 | 0.00% | −48,796−100.0% | Sold out |
| Squadron Capital Management LLC | 0 | $0 | 0.00% | −12,200−100.0% | Sold out |
| Resolute Capital Asset Partners LLC | 0 | $0 | 0.00% | −4,000−100.0% | Sold out |
| Sound Income Strategies, LLC | 0 | $0 | 0.00% | −200−100.0% | Sold out |