Spruce Biosciences, Inc.

SPRB

Exchange: Nasdaq
Industry: Pharmaceutical Preparations
SEC CIK: 0001683553

SEC filings (opens in a new tab)

No open-market purchases or sales by Spruce Biosciences, Inc. insiders were filed in the last 90 days; 65 institutions reported holding it in 13F filings for Q2 2026, worth $116.3M in total; no superinvestor holds it.

Q2 2026 vs. Q1 2026

How the institutions holding Spruce Biosciences, Inc. changed between Q1 2026 and Q2 2026.

All holders in Q2 2026 All holders in Q1 2026

13F holders of SPRB: Q1 2026 compared with Q2 2026
Measure	Q1 2026	Q2 2026	Change
Holders	32	65	+33
Shares	739.8K	2.15M	+1.41M (+191.0%)
Value	$48.3M	$116.3M	+$67.9M (+140.5%)

New holders (37)

Institutions that held Spruce Biosciences, Inc. at the end of Q2 2026 but not at the end of Q1 2026.

Institutions new to SPRB in Q2 2026
Institution	Shares	Value	% of portfolio
AIGH Capital Management LLC	250,000	$13.5M	1.22%
OrbiMed Advisors LLC	200,000	$10.8M	0.20%
AWM Investment Company, Inc.	146,988	$7.94M	0.69%
Cable Car Capital LLC	60,000	$3.24M	0.07%
Eversept Partners, LP	40,000	$2.16M	0.12%
Affinity Asset Advisors, LLC	30,000	$1.62M	0.08%
Stonepine Capital Management, LLC	28,795	$1.55M	1.18%
Point72 Asset Management, L.P.	28,278	$1.53M	0.00%
Northern Trust Corp	21,083	$1.14M	0.00%
Rosalind Advisors, Inc.	20,000	$1.08M	0.41%
Knott David M Jr	20,000	$1.08M	0.57%
Ameriprise Financial Inc	18,834	$1.02M	0.00%
Vanguard Portfolio Management LLC	18,496	$998.8K	0.00%
Dimensional Fund Advisors LP	8,813	$476.6K	0.00%
State Board of Administration of Florida Retirement System	7,182	$387.8K	0.00%
Bank of New York Mellon Corp	6,779	$366.1K	0.00%
Charles Schwab Investment Management Inc	5,896	$318.4K	0.00%
Renaissance Technologies LLC	4,700	$253.8K	0.00%
Pale Fire Capital SE	3,818	$206.2K	0.01%
Rhumbline Advisers	3,519	$190.0K	0.00%
SkyView Investment Advisors, LLC	3,000	$162.0K	0.13%
Deutsche Bank AG	2,652	$143.2K	0.00%
Wells Fargo & Company	2,329	$125.8K	0.00%
New York State Common Retirement Fund	1,900	$102.6K	0.00%
Mirae Asset Global ETFs Holdings Ltd.	1,252	$67.6K	0.00%
JPMorgan Chase & Co	1,127	$63.0K	0.00%
Police & Firemen's Retirement System of New Jersey	864	$46.7K	0.00%
Barclays PLC	674	$36.4K	0.00%
BNP Paribas Arbitrage, SA	453	$24.5K	0.00%
FMR LLC	343	$18.5K	0.00%
Legal & General Group Plc	264	$14.2K	0.00%
Ameritas Investment Partners, Inc.	247	$13.3K	0.00%
Russell Investments Group, Ltd.	217	$11.7K	0.00%
SBI Securities Co., Ltd.	201	$10.9K	0.00%
Royal Bank of Canada	166	$8.00K	0.00%
Sterling Capital Management LLC	43	$2.32K	0.00%
Friedenthal Financial	7	$378	0.00%

Sold out (4)

Institutions that held Spruce Biosciences, Inc. at the end of Q1 2026 and filed for Q2 2026 without it.

Institutions that sold out of SPRB in Q2 2026
Institution	Shares, Q1 2026	Value, Q1 2026
Wellington Management Group LLP	48,796	$3.19M
Squadron Capital Management LLC	12,200	$797.3K
Resolute Capital Asset Partners LLC	4,000	$261.4K
Sound Income Strategies, LLC	200	$13.9K