Rhythm Pharmaceuticals, Inc.
RYTM- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001649904
In the last 90 days, Rhythm Pharmaceuticals, Inc. insiders filed 0 open-market purchases and 6 sales; 304 institutions reported holding it in 13F filings for Q2 2026, worth $8.55B in total; Duquesne Family Office is the only superinvestor holding it.
13F holders, Q4 2025
Institutional positions in Rhythm Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 281
- +19 vs. Q3 2025
- Shares held
- 72.9M
- +2.01M (+2.8%) vs. Q3 2025
- Total value
- $7.80B
- +$602.5M (+8.4%) vs. Q3 2025
- New holders
- 58
- 107 more added
- Sold out
- 39
- 89 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting RYTM on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 304 | $8.55B |
| Q1 2026 | 285 | $6.42B |
| Q4 2025 | 281 | $7.80B |
| Q3 2025 | 264 | $7.20B |
| Q2 2025 | 227 | $4.20B |
| Q1 2025 | 228 | $3.44B |
| Q4 2024 | 203 | $3.63B |
| Q3 2024 | 176 | $3.55B |
| Q2 2024 | 165 | $2.85B |
| Q1 2024 | 167 | $2.95B |
| Q4 2023 | 169 | $3.07B |
| Q3 2023 | 144 | $1.56B |
| Q2 2023 | 116 | $1.09B |
| Q1 2023 | 126 | $1.08B |
| Q4 2022 | 115 | $1.81B |
| Q3 2022 | 101 | $1.45B |
| Q2 2022 | 90 | $190.8M |
| Q1 2022 | 111 | $562.7M |
| Q4 2021 | 98 | $483.6M |
| Q3 2021 | 97 | $626.3M |
| Q2 2021 | 105 | $905.6M |
| Q1 2021 | 124 | $1.01B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Rhythm Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Xponance, Inc. | 4,269 | $457.0K | 0.00% | +107+2.6% | Added |
| Ameritas Investment Partners, Inc. | 4,365 | $467.2K | 0.01% | 00.0% | Unchanged |
| Mackenzie Financial Corp | 4,398 | $468.6K | 0.00% | 00.0% | Unchanged |
| Verition Fund Management LLC | 4,504 | $482.1K | 0.00% | +4,504 | New |
| Vestmark Advisory Solutions, Inc. | 4,560 | $488.1K | 0.01% | +4,560 | New |
| Caption Management, LLC | 4,614 | $493.9K | 0.02% | +4,614 | New |
| The PNC Financial Services Group, Inc. | 4,659 | $498.7K | 0.00% | +442+10.5% | Added |
| PSP Research LLC | 4,738 | $507.2K | 0.44% | +4,738 | New |
| Gotham Asset Management, LLC | 4,851 | $519.3K | 0.00% | −4−0.1% | Reduced |
| Two Sigma Securities, LLC | 4,943 | $529.1K | 0.07% | +4,943 | New |
| Voleon Capital Management LP | 5,025 | $537.9K | 0.01% | −21,872−81.3% | Reduced |
| AlphaCentric Advisors LLC | 5,052 | $540.8K | 0.54% | +5,052 | New |
| LPL Financial LLC | 5,427 | $580.9K | 0.00% | +1,437+36.0% | Added |
| Public Employees Retirement Association of Colorado | 5,463 | $585.0K | 0.00% | 00.0% | Unchanged |
| Quantedge Capital Pte Ltd | 5,600 | $599.4K | 0.29% | −12,200−68.5% | Reduced |
| Jasper Ridge Partners, L.P. | 5,639 | $603.6K | 0.01% | 00.0% | Unchanged |
| Legato Capital Management LLC | 5,723 | $612.6K | 0.05% | +5,723 | New |
| Great West Life Assurance Co | 5,797 | $621.0K | 0.00% | −8,598−59.7% | Reduced |
| Virtus Investment Advisers, Inc. | 6,017 | $644.1K | 0.18% | −1,035−14.7% | Reduced |
| Exchange Traded Concepts, LLC | 6,080 | $650.8K | 0.01% | −306−4.8% | Reduced |
| Acadian Asset Management LLC | 6,105 | $652.0K | 0.00% | +6,105 | New |
| Principal Financial Group Inc | 6,198 | $663.4K | 0.00% | −6,400−50.8% | Reduced |
| E. Ohman J:or Asset Management AB | 6,589 | $705.3K | 0.02% | −1,624−19.8% | Reduced |
| Jump Financial, LLC | 6,759 | $723.5K | 0.01% | +6,759 | New |
| Leo Wealth, LLC | 6,952 | $744.1K | 0.05% | −915−11.6% | Reduced |
| Bellevue Group AG | 7,504 | $803.2K | 0.02% | −1,549−17.1% | Reduced |
| Allianz Asset Management GmbH | 8,000 | $856.3K | 0.00% | −4,100−33.9% | Reduced |
| Teacher Retirement System of Texas | 8,359 | $894.7K | 0.00% | −4,601−35.5% | Reduced |
| Headlands Technologies LLC | 8,632 | $924.0K | 0.08% | +8,632 | New |
| Virginia Retirement Systems Et Al | 9,200 | $984.8K | 0.01% | +2,500+37.3% | Added |
| Fred Alger Management, LLC | 9,301 | $995.6K | 0.00% | −3,034−24.6% | Reduced |
| Man Group plc | 9,558 | $1.02M | 0.00% | −119,772−92.6% | Reduced |
| Toth Financial Advisory Corp | 10,000 | $1.07M | 0.12% | 00.0% | Unchanged |
| Cannon Financial Strategists, Inc. | 10,000 | $1.07M | 0.15% | 00.0% | Unchanged |
| Knights of Columbus Asset Advisors LLC | 10,314 | $1.10M | 0.06% | +10,314 | New |
| XTX Topco Ltd | 10,433 | $1.12M | 0.03% | +10,433 | New |
| China Universal Asset Management Co., Ltd. | 10,875 | $1.16M | 0.09% | −767−6.6% | Reduced |
| Hennion & Walsh Asset Management, Inc. | 10,908 | $1.17M | 0.04% | −33,823−75.6% | Reduced |
| DnB Asset Management AS | 11,163 | $1.19M | 0.00% | +5,635+101.9% | Added |
| SG Americas Securities, LLC | 11,741 | $1.26M | 0.00% | −7,813−40.0% | Reduced |
| Rockefeller Capital Management L.P. | 11,771 | $1.26M | 0.00% | +2,903+32.7% | Added |
| STRS Ohio | 12,000 | $1.28M | 0.00% | −2,800−18.9% | Reduced |
| KLP Kapitalforvaltning AS | 12,000 | $1.28M | 0.00% | +1,000+9.1% | Added |
| Guggenheim Capital LLC | 12,401 | $1.33M | 0.01% | +10,116+442.7% | Added |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 12,435 | $1.33M | 0.00% | +1,709+15.9% | Added |
| ProShare Advisors LLC | 12,622 | $1.35M | 0.00% | +1,323+11.7% | Added |
| Citigroup Inc | 12,720 | $1.36M | 0.00% | −360−2.8% | Reduced |
| Nisa Investment Advisors, LLC | 13,139 | $1.41M | 0.00% | −115−0.9% | Reduced |
| Stifel Financial Corp | 13,247 | $1.42M | 0.00% | −1,208−8.4% | Reduced |
| Police & Firemen's Retirement System of New Jersey | 14,183 | $1.52M | 0.01% | −423−2.9% | Reduced |
| State Board of Administration of Florida Retirement System | 14,650 | $1.57M | 0.00% | 00.0% | Unchanged |
| Arizona State Retirement System | 15,762 | $1.69M | 0.01% | +148+0.9% | Added |
| Handelsbanken Fonder AB | 17,521 | $1.88M | 0.01% | +2,000+12.9% | Added |
| Captrust Financial Advisors | 18,325 | $1.96M | 0.00% | +67+0.4% | Added |
| Advisors Asset Management, Inc. | 18,524 | $1.98M | 0.03% | +4,346+30.7% | Added |
| Wedge Capital Management L L P | 19,247 | $2.06M | 0.04% | −2,997−13.5% | Reduced |
| State of New Jersey Common Pension Fund D | 19,270 | $2.06M | 0.01% | −1,649−7.9% | Reduced |
| Profund Advisors LLC | 21,046 | $2.25M | 0.07% | +8,589+68.9% | Added |
| Intech Investment Management LLC | 21,350 | $2.29M | 0.02% | −2,962−12.2% | Reduced |
| Penserra Capital Management LLC | 21,514 | $2.30M | 0.03% | −8,922−29.3% | Reduced |
| Atom Investors LP | 22,929 | $2.45M | 0.19% | +22,929 | New |
| Creative Planning | 25,206 | $2.70M | 0.00% | +261+1.0% | Added |
| Los Angeles Capital Management LLC | 24,334 | $2.72M | 0.01% | +7,613+45.5% | Added |
| Lazard Asset Management LLC | 25,571 | $2.74M | 0.00% | −4,668−15.4% | Reduced |
| MetLife Investment Management | 29,174 | $3.12M | 0.02% | −1,188−3.9% | Reduced |
| EFG International AG | 29,291 | $3.14M | 0.06% | +29,291 | New |
| Magnetar Financial LLC | 29,598 | $3.17M | 0.03% | +29,598 | New |
| D. E. Shaw & Co., Inc. | 31,356 | $3.36M | 0.00% | +27,771+774.6% | Added |
| Dimensional Fund Advisors LP | 32,018 | $3.43M | 0.00% | +3,640+12.8% | Added |
| Squarepoint Ops LLC | 32,829 | $3.51M | 0.01% | +32,829 | New |
| Silvercrest Asset Management Group LLC | 34,127 | $3.65M | 0.03% | +43+0.1% | Added |
| Nicholas Investment Partners, LP | 34,710 | $3.72M | 0.27% | +34,710 | New |
| Mirae Asset Global ETFs Holdings Ltd. | 34,901 | $3.73M | 0.01% | +7,779+28.7% | Added |
| Rhenman & Partners Asset Management AB | 35,000 | $3.75M | 0.35% | 00.0% | Unchanged |
| State of Wisconsin Investment Board | 36,079 | $3.86M | 0.01% | −4,697−11.5% | Reduced |
| SEI Investments Co | 37,432 | $4.01M | 0.00% | +5,774+18.2% | Added |
| Kennedy Capital Management, Inc. | 39,887 | $4.27M | 0.09% | +312+0.8% | Added |
| PFM Health Sciences, LP | 40,210 | $4.30M | 0.44% | −7,952−16.5% | Reduced |
| Harbor Capital Advisors, Inc. | 40,896 | $4.38M | 0.34% | +3,691+9.9% | Added |
| Raymond James Financial Inc | 41,115 | $4.40M | 0.00% | −2,978−6.8% | Reduced |
| Hillsdale Investment Management Inc. | 42,300 | $4.53M | 0.12% | −300−0.7% | Reduced |
| HighVista Strategies LLC | 42,867 | $4.59M | 1.18% | +5,385+14.4% | Added |
| Harvest Investment Services, LLC | 43,953 | $4.70M | 0.89% | −4,187−8.7% | Reduced |
| WCM Investment Management, LLC | 44,805 | $4.78M | 0.01% | −2,928−6.1% | Reduced |
| Victory Capital Management Inc | 45,381 | $4.86M | 0.00% | +2,498+5.8% | Added |
| Nan Fung Group Holdings Ltd | 49,120 | $5.26M | 4.71% | 00.0% | Unchanged |
| ADAR1 Capital Management, LLC | 51,349 | $5.50M | 0.41% | +1,778+3.6% | Added |
| Prudential Financial Inc | 53,145 | $5.69M | 0.01% | −19,865−27.2% | Reduced |
| Granahan Investment Management Inc | 53,452 | $5.72M | 0.24% | +3,724+7.5% | Added |
| California State Teachers Retirement System | 53,537 | $5.73M | 0.01% | +4,603+9.4% | Added |
| TD Asset Management Inc | 55,050 | $5.89M | 0.00% | −4,514−7.6% | Reduced |
| Legal & General Group Plc | 55,075 | $5.90M | 0.00% | −2,301−4.0% | Reduced |
| Rafferty Asset Management, LLC | 55,526 | $5.94M | 0.02% | −208−0.4% | Reduced |
| EAM Investors, LLC | 57,327 | $6.14M | 0.68% | −1,153−2.0% | Reduced |
| StemPoint Capital LP | 58,915 | $6.31M | 1.08% | −32,529−35.6% | Reduced |
| PDT Partners, LLC | 59,436 | $6.36M | 0.41% | −26,700−31.0% | Reduced |
| Manufacturers Life Insurance Company, The | 59,609 | $6.37M | 0.01% | −1,308−2.1% | Reduced |
| Voloridge Investment Management, LLC | 60,575 | $6.48M | 0.02% | −307,688−83.6% | Reduced |
| Castleark Management LLC | 64,479 | $6.90M | 0.20% | +21,940+51.6% | Added |
| Norges Bank | 66,213 | $7.09M | 0.00% | +66,213 | New |