Praxis Precision Medicines, Inc.
PRAX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001689548
No open-market purchases or sales by Praxis Precision Medicines, Inc. insiders were filed in the last 90 days; 309 institutions reported holding it in 13F filings for Q2 2026, worth $11.3B in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Praxis Precision Medicines, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 250
- +100 vs. Q3 2025
- Shares held
- 29.5M
- +4.80M (+19.5%) vs. Q3 2025
- Total value
- $8.69B
- +$7.38B (+564.4%) vs. Q3 2025
- New holders
- 115
- 87 more added
- Sold out
- 15
- 44 more reduced
2 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting PRAX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 309 | $11.3B |
| Q1 2026 | 291 | $10.2B |
| Q4 2025 | 250 | $8.69B |
| Q3 2025 | 152 | $1.31B |
| Q2 2025 | 144 | $1.02B |
| Q1 2025 | 150 | $889.3M |
| Q4 2024 | 162 | $1.67B |
| Q3 2024 | 134 | $1.09B |
| Q2 2024 | 113 | $762.1M |
| Q1 2024 | 111 | $971.3M |
| Q4 2023 | 60 | $178.6M |
| Q3 2023 | 74 | $195.6M |
| Q2 2023 | 78 | $134.6M |
| Q1 2023 | 87 | $43.1M |
| Q4 2022 | 104 | $108.1M |
| Q3 2022 | 108 | $95.7M |
| Q2 2022 | 95 | $105.5M |
| Q1 2022 | 103 | $463.4M |
| Q4 2021 | 100 | $863.1M |
| Q3 2021 | 93 | $791.5M |
| Q2 2021 | 80 | $751.0M |
| Q1 2021 | 68 | $1.19B |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Praxis Precision Medicines, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Canada Pension Plan Investment Board | 69,712 | $20.5M | 0.01% | +69,712 | New |
| Alyeska Investment Group, L.P. | 74,376 | $21.9M | 0.06% | −67,140−47.4% | Reduced |
| American Century Companies Inc | 75,366 | $22.2M | 0.01% | +60,098+393.6% | Added |
| Invesco Ltd. | 77,088 | $22.7M | 0.00% | +56,220+269.4% | Added |
| Bank of New York Mellon Corp | 77,897 | $23.0M | 0.00% | +21,609+38.4% | Added |
| Algert Global LLC | 80,640 | $23.8M | 0.37% | −80,178−49.9% | Reduced |
| Silverarc Capital Management, LLC | 82,465 | $24.3M | 3.52% | +31,255+61.0% | Added |
| Acuta Capital Partners, LLC | 83,036 | $24.5M | 16.62% | +33,285+66.9% | Added |
| Ikarian Capital, LLC | 86,581 | $25.5M | 3.30% | +58,010+203.0% | Added |
| First Trust Advisors LP | 88,704 | $26.1M | 0.02% | +59,738+206.2% | Added |
| UBS Group AG | 89,200 | $26.3M | 0.01% | −7,612−7.9% | Reduced |
| OrbiMed Advisors LLC | 94,500 | $27.9M | 0.57% | +94,500 | New |
| Velan Capital Investment Management LP | 100,781 | $29.7M | 17.28% | −32,024−24.1% | Reduced |
| Woodline Partners LP | 105,412 | $31.1M | 0.12% | −312,257−74.8% | Reduced |
| Candriam Luxembourg S.C.A. | 110,590 | $32.6M | 0.16% | +47,724+75.9% | Added |
| Sofinnova Investments, Inc. | 125,722 | $37.1M | 1.60% | −47,111−27.3% | Reduced |
| Standard Life Aberdeen plc | 134,992 | $39.8M | 0.06% | +134,992 | New |
| Qube Research & Technologies Ltd | 168,897 | $49.8M | 0.07% | +111,593+194.7% | Added |
| Wellington Management Group LLP | 176,562 | $52.0M | 0.01% | +115,321+188.3% | Added |
| Affinity Asset Advisors, LLC | 185,000 | $54.5M | 3.92% | +185,000 | New |
| Northern Trust Corp | 192,284 | $56.7M | 0.01% | +23,931+14.2% | Added |
| Charles Schwab Investment Management Inc | 198,301 | $58.4M | 0.01% | +36,640+22.7% | Added |
| Pictet Asset Management Holding SA | 240,588 | $71.1M | 0.07% | +240,588 | New |
| T. Rowe Price Investment Management, Inc. | 276,392 | $81.5M | 0.05% | +276,392 | New |
| Hood River Capital Management LLC | 289,467 | $85.3M | 0.94% | +289,467 | New |
| Vivo Capital, LLC | 328,895 | $96.9M | 6.27% | +130,000+65.4% | Added |
| Franklin Resources Inc | 356,074 | $104.9M | 0.03% | +41,917+13.3% | Added |
| Soleus Capital Management, L.P. | 362,966 | $107.0M | 4.54% | −496,200−57.8% | Reduced |
| Ra Capital Management, L.P. | 373,787 | $110.2M | 1.13% | +373,787 | New |
| Logos Global Management LP | 375,000 | $110.5M | 7.37% | +250,000+200.0% | Added |
| Assenagon Asset Management S.A. | 408,787 | $120.5M | 0.18% | −992−0.2% | Reduced |
| Point72 Asset Management, L.P. | 492,346 | $145.1M | 0.23% | −1,003,640−67.1% | Reduced |
| Bank of America Corp | 522,763 | $154.1M | 0.01% | +39,902+8.3% | Added |
| Barclays PLC | 530,751 | $156.4M | 0.06% | +454,114+592.6% | Added |
| Geode Capital Management, LLC | 562,379 | $165.8M | 0.01% | +105,347+23.1% | Added |
| Goldman Sachs Group Inc | 716,184 | $211.1M | 0.03% | +123,163+20.8% | Added |
| Price T Rowe Associates Inc | 785,987 | $231.7M | 0.02% | −217,503−21.7% | Reduced |
| State Street Corp | 882,215 | $260.0M | 0.01% | −24,893−2.7% | Reduced |
| Morgan Stanley | 889,889 | $262.3M | 0.02% | +246,394+38.3% | Added |
| Deerfield Management Company, L.P. (Series C) | 903,351 | $266.3M | 3.41% | +62,500+7.4% | Added |
| Driehaus Capital Management LLC | 933,061 | $275.0M | 1.87% | +432,510+86.4% | Added |
| Cormorant Asset Management, LP | 950,000 | $280.0M | 15.87% | −50,000−5.0% | Reduced |
| Adage Capital Partners GP, L.L.C. | 965,313 | $284.5M | 0.43% | −1,408,772−59.3% | Reduced |
| Baker Bros. Advisors LP | 1,126,488 | $332.0M | 1.94% | +437,000+63.4% | Added |
| Orbis Allan Gray Ltd | 1,255,162 | $369.9M | 1.55% | +1,255,162 | New |
| FMR LLC | 1,358,675 | $400.5M | 0.02% | +1,315,464+3,044.3% | Added |
| Vanguard Group Inc | 1,460,933 | $430.6M | 0.01% | +193,647+15.3% | Added |
| Perceptive Advisors LLC | 1,995,986 | $588.3M | 10.78% | +431,432+27.6% | Added |
| BlackRock, Inc. | 2,078,500 | $612.6M | 0.01% | +277,420+15.4% | Added |
| Janus Henderson Group PLC | 3,240,086 | $954.8M | 0.43% | +476,227+17.2% | Added |
| 5AM Venture Management, LLC | 0 | $0 | 0.00% | −170,000−100.0% | Sold out |
| Kennedy Capital Management, Inc. | 0 | $0 | 0.00% | −76,218−100.0% | Sold out |
| Tri Locum Partners LP | 0 | $0 | 0.00% | −75,986−100.0% | Sold out |
| Sphera Funds Management Ltd. | 0 | $0 | 0.00% | −57,901−100.0% | Sold out |
| Jane Street Group, LLC | 0 | $0 | 0.00% | −31,687−100.0% | Sold out |
| Knott David M Jr | 0 | $0 | 0.00% | −28,000−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −22,529−100.0% | Sold out |
| Dark Forest Capital Management LP | 0 | $0 | 0.00% | −21,684−100.0% | Sold out |
| PCG Wealth Advisors, LLC | 0 | $0 | 0.00% | −14,483−100.0% | Sold out |
| Alps Advisors Inc | 0 | $0 | 0.00% | −10,424−100.0% | Sold out |
| Freestone Grove Partners LP | 0 | $0 | 0.00% | −8,269−100.0% | Sold out |
| Phoenix Holdings Ltd. | 0 | $0 | 0.00% | −6,817−100.0% | Sold out |
| Gsa Capital Partners LLP | 0 | $0 | 0.00% | −5,740−100.0% | Sold out |
| Jefferies Financial Group Inc. | 0 | $0 | 0.00% | −2,000−100.0% | Sold out |
| Clear Street Markets LLC | 0 | $0 | 0.00% | −164−100.0% | Sold out |
| FSA Wealth Management LLC | – | – | – | – | Not filed |
| Hemington Wealth Management | – | – | – | – | Not filed |