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Praxis Precision Medicines, Inc.

PRAX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001689548

No open-market purchases or sales by Praxis Precision Medicines, Inc. insiders were filed in the last 90 days; 309 institutions reported holding it in 13F filings for Q2 2026, worth $11.3B in total; no superinvestor holds it.

13F holders, Q2 2025

Institutional positions in Praxis Precision Medicines, Inc. as of Jun 30, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
144
−6 vs. Q1 2025
Shares held
24.2M
+699.7K (+3.0%) vs. Q1 2025
Total value
$1.02B
+$126.3M (+14.2%) vs. Q1 2025
New holders
25
65 more added
Sold out
31
36 more reduced

Compare with Q1 2025: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting PRAX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ2 2025: 144 institutions
Q1 2021: 68 institutionsQ2 2021: 80 institutionsQ3 2021: 93 institutionsQ4 2021: 100 institutionsQ1 2022: 103 institutionsQ2 2022: 95 institutionsQ3 2022: 108 institutionsQ4 2022: 104 institutionsQ1 2023: 87 institutionsQ2 2023: 78 institutionsQ3 2023: 74 institutionsQ4 2023: 60 institutionsQ1 2024: 111 institutionsQ2 2024: 113 institutionsQ3 2024: 134 institutionsQ4 2024: 162 institutionsQ1 2025: 150 institutionsQ2 2025: 144 institutionsQ3 2025: 152 institutionsQ4 2025: 250 institutionsQ1 2026: 291 institutionsQ2 2026: 309 institutions
Value heldQ2 2025: $1.02B
Q1 2021: $1.19BQ2 2021: $751.0MQ3 2021: $791.5MQ4 2021: $863.1MQ1 2022: $463.4MQ2 2022: $105.5MQ3 2022: $95.7MQ4 2022: $108.1MQ1 2023: $43.1MQ2 2023: $134.6MQ3 2023: $195.6MQ4 2023: $178.6MQ1 2024: $971.3MQ2 2024: $762.1MQ3 2024: $1.09BQ4 2024: $1.67BQ1 2025: $889.3MQ2 2025: $1.02BQ3 2025: $1.31BQ4 2025: $8.69BQ1 2026: $10.2BQ2 2026: $11.3B
Institutions holding PRAX and their total value by quarter
QuarterHoldersValue
Q2 2026309$11.3B
Q1 2026291$10.2B
Q4 2025250$8.69B
Q3 2025152$1.31B
Q2 2025144$1.02B
Q1 2025150$889.3M
Q4 2024162$1.67B
Q3 2024134$1.09B
Q2 2024113$762.1M
Q1 2024111$971.3M
Q4 202360$178.6M
Q3 202374$195.6M
Q2 202378$134.6M
Q1 202387$43.1M
Q4 2022104$108.1M
Q3 2022108$95.7M
Q2 202295$105.5M
Q1 2022103$463.4M
Q4 2021100$863.1M
Q3 202193$791.5M
Q2 202180$751.0M
Q1 202168$1.19B

Institutions, Q2 2025

Shares, value and share of portfolio for each institution holding Praxis Precision Medicines, Inc.; share changes are against Q1 2025.

Institutions holding PRAX in Q2 2025
InstitutionSharesValue% of portfolioChange in sharesAction
HighVista Strategies LLC67,288$2.83M1.04%+28,002+71.3%Added
Kennedy Capital Management, Inc.70,445$2.96M0.07%+5,180+7.9%Added
Acuta Capital Partners, LLC74,087$3.12M4.35%−13,054−15.0%Reduced
Pictet Asset Management Holding SA79,143$3.33M0.00%+555+0.7%Added
Ally Bridge Group (NY) LLC80,880$3.40M2.83%−14,702−15.4%Reduced
PFM Health Sciences, LP84,713$3.56M0.31%−76,153−47.3%Reduced
UBS Group AG86,534$3.64M0.00%−106,375−55.1%Reduced
Barclays PLC88,724$3.73M0.00%+56,956+179.3%Added
UBS Asset Management Americas Inc96,945$4.08M0.00%+9,864+11.3%Added
Schonfeld Strategic Advisors LLC100,702$4.23M0.03%+94,628+1,557.9%Added
Sphera Funds Management Ltd.109,757$4.62M1.21%−30,903−22.0%Reduced
Boothbay Fund Management, LLC118,121$4.97M0.16%+71,495+153.3%Added
Verition Fund Management LLC118,482$4.98M0.03%−81,175−40.7%Reduced
Alyeska Investment Group, L.P.125,000$5.26M0.02%−25,000−16.7%Reduced
Velan Capital Investment Management LP149,334$6.28M6.28%−35,666−19.3%Reduced
Charles Schwab Investment Management Inc152,444$6.41M0.00%+11,364+8.1%Added
Vivo Capital, LLC167,600$7.05M0.72%+167,600New
5AM Venture Management, LLC170,000$7.15M2.75%00.0%Unchanged
Tri Locum Partners LP195,432$8.22M2.49%+111,773+133.6%Added
Northern Trust Corp213,712$8.99M0.00%+48,529+29.4%Added
Standard Life Aberdeen plc214,056$9.00M0.02%+126,153+143.5%Added
Logos Global Management LP225,000$9.46M1.26%+225,000New
Goldman Sachs Group Inc225,992$9.50M0.00%+48,728+27.5%Added
Ikarian Capital, LLC276,950$11.6M3.85%+131,448+90.3%Added
Franklin Resources Inc314,150$13.2M0.00%+230.0%Added
Balyasny Asset Management LLC369,254$15.5M0.04%−33,749−8.4%Reduced
CIBC Asset Management Inc388,759$16.3M0.05%00.0%Unchanged
Geode Capital Management, LLC451,731$19.0M0.00%+33,715+8.1%Added
Bank of America Corp453,403$19.1M0.00%−7,304−1.6%Reduced
Driehaus Capital Management LLC530,988$22.3M0.18%+49,390+10.3%Added
Assenagon Asset Management S.A.604,298$25.4M0.04%+96,898+19.1%Added
Deerfield Management Company, L.P. (Series C)686,931$28.9M0.52%+67,000+10.8%Added
Baker Bros. Advisors LP689,488$29.0M0.28%+357,955+108.0%Added
State Street Corp698,093$29.4M0.00%−38,946−5.3%Reduced
Perceptive Advisors LLC752,921$31.7M1.19%−227,973−23.2%Reduced
Point72 Asset Management, L.P.954,075$40.1M0.09%+620,541+186.1%Added
Soleus Capital Management, L.P.966,740$40.7M2.81%−173,000−15.2%Reduced
Vanguard Group Inc1,215,644$51.1M0.00%+128,624+11.8%Added
Morgan Stanley1,226,339$51.6M0.00%+12,670+1.0%Added
Price T Rowe Associates Inc1,473,075$61.9M0.01%+377,350+34.4%Added
BlackRock, Inc.1,590,128$66.9M0.00%+173,193+12.2%Added
Cormorant Asset Management, LP1,625,000$68.3M5.09%−120,000−6.9%Reduced
Adage Capital Partners GP, L.L.C.1,974,585$83.0M0.14%+231,827+13.3%Added
Janus Henderson Group PLC2,533,405$106.5M0.05%+1,026,969+68.2%Added
VR Adviser, LLC0$00.00%−989,985−100.0%Sold out
Capital Research Global Investors0$00.00%−853,746−100.0%Sold out
Walleye Capital LLC0$00.00%−131,756−100.0%Sold out
Sio Capital Management, LLC0$00.00%−112,500−100.0%Sold out
First Turn Management, LLC0$00.00%−71,775−100.0%Sold out
Millennium Management LLC0$00.00%−69,181−100.0%Sold out
ExodusPoint Capital Management, LP0$00.00%−39,975−100.0%Sold out
Moody Aldrich Partners LLC0$00.00%−30,221−100.0%Sold out
Atom Investors LP0$00.00%−19,779−100.0%Sold out
PCG Wealth Advisors, LLC0$00.00%−16,413−100.0%Sold out
Group One Trading, L.P.0$00.00%−10,927−100.0%Sold out
XTX Topco Ltd0$00.00%−10,043−100.0%Sold out
Corebridge Financial, Inc.0$00.00%−8,448−100.0%Sold out
LMR Partners LLP0$00.00%−7,774−100.0%Sold out
Engineers Gate Manager LP0$00.00%−7,606−100.0%Sold out
Y-Intercept (Hong Kong) Ltd0$00.00%−6,250−100.0%Sold out
Shay Capital LLC0$00.00%−5,500−100.0%Sold out
Graham Capital Management, L.P.0$00.00%−5,449−100.0%Sold out
Ameriprise Financial Inc0$00.00%−5,408−100.0%Sold out
SG Americas Securities, LLC0$00.00%−3,004−100.0%Sold out
Aster Capital Management (DIFC) Ltd0$00.00%−62−100.0%Sold out
Quantbot Technologies LP0$00.00%−47−100.0%Sold out
Comerica Bank0$00.00%−40−100.0%Sold out
Clear Street Markets LLC0$00.00%−40−100.0%Sold out
CoreCap Advisors, LLC0$00.00%−20−100.0%Sold out
UMA Financial Services, Inc.0$00.00%−17−100.0%Sold out
Coldstream Capital Management Inc0$00.00%−13−100.0%Sold out
Principal Securities, Inc.0$00.00%−6−100.0%Sold out
TD Private Client Wealth LLC0$00.00%−11−100.0%Sold out
Stephens Consulting, LLC0$00.00%−10−100.0%Sold out
Creative Financial Designs Inc0$00.00%−6−100.0%Sold out