Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q1 2026
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Mar 31, 2026. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 137
- +16 vs. Q4 2025
- Shares held
- 323.4M
- +74.5M (+29.9%) vs. Q4 2025
- Total value
- $504.5M
- +$218.3M (+76.3%) vs. Q4 2025
- New holders
- 31
- 41 more added
- Sold out
- 15
- 26 more reduced
5 institutions that held it in Q4 2025 haven't filed for Q1 2026 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q4 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q1 2026
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q4 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Headlands Technologies LLC | 191,322 | $298.5K | 0.03% | +55,209+40.6% | Added |
| Catalyst Funds Management Pty Ltd | 207,900 | $324.3K | 0.05% | +167,600+415.9% | Added |
| Morgan Stanley | 219,862 | $343.0K | 0.00% | +26,827+13.9% | Added |
| XTX Topco Ltd | 314,614 | $490.8K | 0.01% | +218,524+227.4% | Added |
| Tang Capital Management LLC | 399,700 | $623.5K | 0.03% | +399,700 | New |
| Acadian Asset Management LLC | 445,288 | $693.0K | 0.00% | −194,842−30.4% | Reduced |
| Northern Trust Corp | 494,666 | $771.7K | 0.00% | +82,502+20.0% | Added |
| Compagnie Lombard Odier SCmA | 510,000 | $795.6K | 0.01% | +100,000+24.4% | Added |
| Invesco Ltd. | 512,426 | $799.4K | 0.00% | −82,457−13.9% | Reduced |
| Bank of America Corp | 526,103 | $820.7K | 0.00% | +424,006+415.3% | Added |
| Vanguard Portfolio Management LLC | 546,600 | $852.7K | 0.00% | +546,600 | New |
| ADAR1 Capital Management, LLC | 750,000 | $1.17M | 0.07% | +750,000 | New |
| Mackenzie Financial Corp | 772,677 | $1.21M | 0.00% | +772,677 | New |
| Hennion & Walsh Asset Management, Inc. | 848,138 | $1.32M | 0.04% | −53,084−5.9% | Reduced |
| Ishara Investments LP | 902,000 | $1.41M | 1.42% | +22,000+2.5% | Added |
| Gsa Capital Partners LLP | 930,089 | $1.45M | 0.09% | −66,146−6.6% | Reduced |
| State Street Corp | 964,038 | $1.50M | 0.00% | +79,300+9.0% | Added |
| Goldman Sachs Group Inc | 1,070,517 | $1.67M | 0.00% | +149,313+16.2% | Added |
| Citadel Advisors LLC | 1,094,901 | $1.71M | 0.00% | −616,074−36.0% | Reduced |
| Two Sigma Investments, LP | 1,199,632 | $1.87M | 0.00% | +562,324+88.2% | Added |
| Charles Schwab Investment Management Inc | 1,311,298 | $2.05M | 0.00% | +256,175+24.3% | Added |
| Vanguard Fiduciary Trust Co | 1,332,284 | $2.08M | 0.00% | +1,332,284 | New |
| Renaissance Technologies LLC | 1,600,500 | $2.50M | 0.00% | +1,337,246+508.0% | Added |
| CIBC Bancorp USA Inc. | 1,800,000 | $2.81M | 0.00% | +1,800,000 | New |
| Susquehanna International Group, LLP | 2,121,164 | $3.31M | 0.00% | +913,922+75.7% | Added |
| Marshall Wace, LLP | 2,376,304 | $3.71M | 0.00% | +1,113,937+88.2% | Added |
| UBS Group AG | 2,483,182 | $3.87M | 0.00% | −524,055−17.4% | Reduced |
| Jane Street Group, LLC | 2,665,938 | $4.16M | 0.00% | +941,634+54.6% | Added |
| Geode Capital Management, LLC | 3,169,111 | $4.95M | 0.00% | +669,089+26.8% | Added |
| BlackRock, Inc. | 3,322,219 | $5.18M | 0.00% | +129,771+4.1% | Added |
| Millennium Management LLC | 4,944,731 | $7.71M | 0.01% | +122,998+2.6% | Added |
| Point72 Asset Management, L.P. | 7,814,606 | $12.2M | 0.02% | +7,530,581+2,651.4% | Added |
| Vanguard Capital Management LLC | 9,519,167 | $14.8M | 0.00% | +9,519,167 | New |
| Sessa Capital IM, L.P. | 17,912,961 | $27.9M | 0.53% | +14,912,961+497.1% | Added |
| Siren, L.L.C. | 44,303,518 | $69.1M | 1.92% | +5,384,615+13.8% | Added |
| FMR LLC | 45,056,338 | $70.3M | 0.00% | +7,222,131+19.1% | Added |
| Artal Group S.A. | 154,734,327 | $241.4M | 23.89% | +18,553,846+13.6% | Added |
| Two Sigma Advisers, LP | 0 | $0 | 0.00% | −180,977−100.0% | Sold out |
| Lighthouse Investment Partners, LLC | 0 | $0 | 0.00% | −126,600−100.0% | Sold out |
| Monaco Asset Management SAM | 0 | $0 | 0.00% | −117,188−100.0% | Sold out |
| Two Sigma Securities, LLC | 0 | $0 | 0.00% | −114,632−100.0% | Sold out |
| Caxton Associates LLP | 0 | $0 | 0.00% | −71,027−100.0% | Sold out |
| Squarepoint Ops LLC | 0 | $0 | 0.00% | −60,472−100.0% | Sold out |
| Optiver Holding B.V. | 0 | $0 | 0.00% | −52,595−100.0% | Sold out |
| Virtu Financial LLC | 0 | $0 | 0.00% | −36,468−100.0% | Sold out |
| Vermillion & White Wealth Management Group, LLC | 0 | $0 | 0.00% | −32,000−100.0% | Sold out |
| Tower Research Capital LLC (TRC) | 0 | $0 | 0.00% | −29,093−100.0% | Sold out |
| Tiaa Trust, National Association | 0 | $0 | 0.00% | −20,000−100.0% | Sold out |
| StoneX Group Inc. | 0 | $0 | 0.00% | −16,234−100.0% | Sold out |
| Simplex Trading, LLC | 0 | $0 | 0.00% | −14,758−100.0% | Sold out |
| Lazard Asset Management LLC | 0 | $0 | 0.00% | −14,090−100.0% | Sold out |
| Golden State Wealth Management, LLC | 0 | $0 | 0.00% | −3,700−100.0% | Sold out |
| Vanguard Group Inc | – | – | – | – | Not filed |
| CIBC Private Wealth Group, LLC | – | – | – | – | Not filed |
| Global Retirement Partners, LLC | – | – | – | – | Not filed |
| Comerica Bank | – | – | – | – | Not filed |
| Motiv8 Investments LLC | – | – | – | – | Not filed |