Lexicon Pharmaceuticals, Inc.
LXRX- Exchange
- Nasdaq
- Industry
- Pharmaceutical Preparations
- SEC CIK
- 0001062822
No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.
13F holders, Q4 2025
Institutional positions in Lexicon Pharmaceuticals, Inc. as of Dec 31, 2025. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works
- Institutional holders
- 126
- +6 vs. Q3 2025
- Shares held
- 260.4M
- +5.41M (+2.1%) vs. Q3 2025
- Total value
- $299.5M
- −$44.8M (−13.0%) vs. Q3 2025
- New holders
- 23
- 28 more added
- Sold out
- 17
- 41 more reduced
4 institutions that held it in Q3 2025 haven't filed for Q4 2025 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.
Compare with Q3 2025: new holders, sold out and not filed yet
Holders and value by quarter
Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.
| Quarter | Holders | Value |
|---|---|---|
| Q2 2026 | 149 | $875.1M |
| Q1 2026 | 137 | $504.5M |
| Q4 2025 | 126 | $299.5M |
| Q3 2025 | 124 | $344.4M |
| Q2 2025 | 123 | $242.9M |
| Q1 2025 | 127 | $122.5M |
| Q4 2024 | 127 | $220.1M |
| Q3 2024 | 137 | $453.1M |
| Q2 2024 | 127 | $471.0M |
| Q1 2024 | 118 | $417.8M |
| Q4 2023 | 106 | $279.8M |
| Q3 2023 | 112 | $205.8M |
| Q2 2023 | 123 | $438.2M |
| Q1 2023 | 104 | $353.8M |
| Q4 2022 | 105 | $280.5M |
| Q3 2022 | 98 | $357.3M |
| Q2 2022 | 86 | $221.0M |
| Q1 2022 | 101 | $251.3M |
| Q4 2021 | 110 | $478.9M |
| Q3 2021 | 96 | $583.0M |
| Q2 2021 | 107 | $540.2M |
| Q1 2021 | 107 | $711.5M |
Institutions, Q4 2025
Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q3 2025.
| Institution | Shares | Value | % of portfolio | Change in shares | Action |
|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 284,025 | $326.6K | 0.00% | +284,025 | New |
| Compagnie Lombard Odier SCmA | 410,000 | $471.5K | 0.01% | 00.0% | Unchanged |
| Northern Trust Corp | 412,164 | $474.0K | 0.00% | +42,370+11.5% | Added |
| Invesco Ltd. | 594,883 | $684.1K | 0.00% | +73,480+14.1% | Added |
| Acadian Asset Management LLC | 640,130 | $732.0K | 0.00% | +603,225+1,634.5% | Added |
| Two Sigma Investments, LP | 637,308 | $732.9K | 0.00% | +78,300+14.0% | Added |
| Ishara Investments LP | 880,000 | $1.01M | 1.18% | +880,000 | New |
| State Street Corp | 884,738 | $1.02M | 0.00% | +4,617+0.5% | Added |
| Hennion & Walsh Asset Management, Inc. | 901,222 | $1.04M | 0.04% | +122,010+15.7% | Added |
| Goldman Sachs Group Inc | 921,204 | $1.06M | 0.00% | +861,857+1,452.2% | Added |
| Gsa Capital Partners LLP | 996,235 | $1.15M | 0.10% | −206,671−17.2% | Reduced |
| Charles Schwab Investment Management Inc | 1,055,123 | $1.21M | 0.00% | −89,509−7.8% | Reduced |
| Susquehanna International Group, LLP | 1,207,242 | $1.39M | 0.00% | +245,182+25.5% | Added |
| Marshall Wace, LLP | 1,262,367 | $1.45M | 0.00% | +1,262,367 | New |
| Citadel Advisors LLC | 1,710,975 | $1.97M | 0.00% | −923,052−35.0% | Reduced |
| Jane Street Group, LLC | 1,724,304 | $1.98M | 0.00% | +1,267,774+277.7% | Added |
| CIBC Private Wealth Group, LLC | 1,950,000 | $2.24M | 0.00% | −450,257−18.8% | Reduced |
| Geode Capital Management, LLC | 2,500,022 | $2.88M | 0.00% | +102,099+4.3% | Added |
| Sessa Capital IM, L.P. | 3,000,000 | $3.45M | 0.07% | 00.0% | Unchanged |
| UBS Group AG | 3,007,237 | $3.46M | 0.00% | +2,654,315+752.1% | Added |
| BlackRock, Inc. | 3,192,448 | $3.67M | 0.00% | −202,524−6.0% | Reduced |
| Millennium Management LLC | 4,821,733 | $5.54M | 0.00% | +991,073+25.9% | Added |
| Vanguard Group Inc | 9,606,549 | $11.0M | 0.00% | +84,675+0.9% | Added |
| FMR LLC | 37,834,207 | $43.5M | 0.00% | −845,541−2.2% | Reduced |
| Siren, L.L.C. | 38,918,903 | $44.8M | 1.34% | 00.0% | Unchanged |
| Artal Group S.A. | 136,180,481 | $156.6M | 21.91% | 00.0% | Unchanged |
| Jacobs Levy Equity Management, Inc | 0 | $0 | 0.00% | −692,727−100.0% | Sold out |
| China Universal Asset Management Co., Ltd. | 0 | $0 | 0.00% | −63,698−100.0% | Sold out |
| Commonwealth Equity Services, LLC | 0 | $0 | 0.00% | −35,738−100.0% | Sold out |
| JPMorgan Chase & Co | 0 | $0 | 0.00% | −30,037−100.0% | Sold out |
| Scientech Research LLC | 0 | $0 | 0.00% | −24,884−100.0% | Sold out |
| Ieq Capital, LLC | 0 | $0 | 0.00% | −16,266−100.0% | Sold out |
| Mirae Asset Global Investments Co., Ltd. | 0 | $0 | 0.00% | −14,049−100.0% | Sold out |
| ProShare Advisors LLC | 0 | $0 | 0.00% | −12,946−100.0% | Sold out |
| North Star Asset Management Inc | 0 | $0 | 0.00% | −11,500−100.0% | Sold out |
| SG Americas Securities, LLC | 0 | $0 | 0.00% | −10,830−100.0% | Sold out |
| GF Fund Management Co. Ltd. | 0 | $0 | 0.00% | −7,818−100.0% | Sold out |
| Advisory Services Network, LLC | 0 | $0 | 0.00% | −3,242−100.0% | Sold out |
| Daiwa Securities Group Inc. | 0 | $0 | 0.00% | −1,369−100.0% | Sold out |
| Federation des caisses Desjardins du Quebec | 0 | $0 | 0.00% | −571−100.0% | Sold out |
| Essential Partners LLC | 0 | $0 | 0.00% | −511−100.0% | Sold out |
| TFC Financial Management | 0 | $0 | 0.00% | −500−100.0% | Sold out |
| IFP Advisors, Inc | 0 | $0 | 0.00% | −1−100.0% | Sold out |
| Cubist Systematic Strategies, LLC | – | – | – | – | Not filed |
| Point72 Asia (Singapore) Pte. Ltd. | – | – | – | – | Not filed |
| Wolverine Trading, LLC | – | – | – | – | Not filed |
| Point72 (DIFC) Ltd | – | – | – | – | Not filed |