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Lexicon Pharmaceuticals, Inc.

LXRX
Exchange
Nasdaq
Industry
Pharmaceutical Preparations
SEC CIK
0001062822

No open-market purchases or sales by Lexicon Pharmaceuticals, Inc. insiders were filed in the last 90 days; 149 institutions reported holding it in 13F filings for Q2 2026, worth $875.1M in total; no superinvestor holds it.

13F holders, Q4 2024

Institutional positions in Lexicon Pharmaceuticals, Inc. as of Dec 31, 2024. Investment managers with $100 million or more in US stocks report their long positions on Form 13F within 45 days after each quarter ends. How 13F works

Institutional holders
127
−9 vs. Q3 2024
Shares held
297.7M
+9.07M (+3.1%) vs. Q3 2024
Total value
$220.1M
−$232.9M (−51.4%) vs. Q3 2024
New holders
25
45 more added
Sold out
34
24 more reduced

1 institution that held it in Q3 2024 haven't filed for Q4 2024 yet. Not filing isn't selling, so they aren't counted as sold out or in the changes above.

Compare with Q3 2024: new holders, sold out and not filed yet

Holders and value by quarter

Institutions reporting LXRX on Form 13F each quarter since Q1 2021, and the total value they reported. Values are as of each quarter end, so they also move with the share price.

Institutional holdersQ4 2024: 127 institutions
Q1 2021: 107 institutionsQ2 2021: 107 institutionsQ3 2021: 96 institutionsQ4 2021: 110 institutionsQ1 2022: 101 institutionsQ2 2022: 86 institutionsQ3 2022: 98 institutionsQ4 2022: 105 institutionsQ1 2023: 104 institutionsQ2 2023: 123 institutionsQ3 2023: 112 institutionsQ4 2023: 106 institutionsQ1 2024: 118 institutionsQ2 2024: 127 institutionsQ3 2024: 137 institutionsQ4 2024: 127 institutionsQ1 2025: 127 institutionsQ2 2025: 123 institutionsQ3 2025: 124 institutionsQ4 2025: 126 institutionsQ1 2026: 137 institutionsQ2 2026: 149 institutions
Value heldQ4 2024: $220.1M
Q1 2021: $711.5MQ2 2021: $540.2MQ3 2021: $583.0MQ4 2021: $478.9MQ1 2022: $251.3MQ2 2022: $221.0MQ3 2022: $357.3MQ4 2022: $280.5MQ1 2023: $353.8MQ2 2023: $438.2MQ3 2023: $205.8MQ4 2023: $279.8MQ1 2024: $417.8MQ2 2024: $471.0MQ3 2024: $453.1MQ4 2024: $220.1MQ1 2025: $122.5MQ2 2025: $242.9MQ3 2025: $344.4MQ4 2025: $299.5MQ1 2026: $504.5MQ2 2026: $875.1M
Institutions holding LXRX and their total value by quarter
QuarterHoldersValue
Q2 2026149$875.1M
Q1 2026137$504.5M
Q4 2025126$299.5M
Q3 2025124$344.4M
Q2 2025123$242.9M
Q1 2025127$122.5M
Q4 2024127$220.1M
Q3 2024137$453.1M
Q2 2024127$471.0M
Q1 2024118$417.8M
Q4 2023106$279.8M
Q3 2023112$205.8M
Q2 2023123$438.2M
Q1 2023104$353.8M
Q4 2022105$280.5M
Q3 202298$357.3M
Q2 202286$221.0M
Q1 2022101$251.3M
Q4 2021110$478.9M
Q3 202196$583.0M
Q2 2021107$540.2M
Q1 2021107$711.5M

Institutions, Q4 2024

Shares, value and share of portfolio for each institution holding Lexicon Pharmaceuticals, Inc.; share changes are against Q3 2024.

Institutions holding LXRX in Q4 2024
InstitutionSharesValue% of portfolioChange in sharesAction
Covestor Ltd81$00.00%+15+22.7%Added
Farther Finance Advisors, LLC2$10.00%00.0%Unchanged
GWM Advisors LLC5$40.00%+5New
EverSource Wealth Advisors, LLC32$240.00%+32New
Coppell Advisory Solutions LLC52$370.00%00.0%Unchanged
CBIZ Investment Advisory Services, LLC71$520.00%+71New
Larson Financial Group LLC100$740.00%00.0%Unchanged
The PNC Financial Services Group, Inc.111$820.00%00.0%Unchanged
Comerica Bank122$900.00%+122New
Syntax Research, Inc.142$1050.00%00.0%Unchanged
Jones Financial Companies LLLP142$1050.00%+142New
Signaturefd, LLC388$2870.00%−786−67.0%Reduced
Steward Partners Investment Advisory, LLC400$2950.00%00.0%Unchanged
SJS Investment Consulting Inc.400$2960.00%00.0%Unchanged
Northwestern Mutual Wealth Management Co500$3690.00%00.0%Unchanged
Advisor Group Holdings, Inc.742$5490.00%00.0%Unchanged
Global Retirement Partners, LLC1,000$7390.00%00.0%Unchanged
Pinney & Scofield, Inc.1,000$7390.00%+1,000New
Optiver Holding B.V.1,200$8860.00%+1,200New
Daiwa Securities Group Inc.1,369$1.00K0.00%00.0%Unchanged
CWM, LLC1,131$1.00K0.00%+1,031+1,031.0%Added
US Bancorp1,624$1.20K0.00%+1,624New
Quintet Private Bank (Europe) S.A.1,928$1.42K0.00%00.0%Unchanged
Manchester Capital Management LLC2,380$1.76K0.00%00.0%Unchanged
Sterling Capital Management LLC2,477$1.83K0.00%+2,205+810.7%Added
Amalgamated Bank2,409$2.00K0.00%00.0%Unchanged
R Squared Ltd3,040$2.25K0.00%+3,040New
SBI Securities Co., Ltd.3,064$2.26K0.00%+3,064New
Nordwand Advisors, LLC4,000$2.95K0.00%00.0%Unchanged
Ameritas Investment Partners, Inc.8,867$6.55K0.00%00.0%Unchanged
Royal Bank of Canada9,911$7.00K0.00%−1,488−13.1%Reduced
Estabrook Capital Management10,000$7.38K0.00%00.0%Unchanged
Unique Wealth Strategies, LLC10,000$7.38K0.00%+10,000New
CIBC World Markets Corp10,744$7.93K0.00%+10,744New
Berger Financial Group, Inc10,929$8.07K0.00%00.0%Unchanged
North Star Asset Management Inc11,500$8.49K0.00%−1,050−8.4%Reduced
Raymond James Financial Inc11,912$8.80K0.00%+11,912New
Chemistry Wealth Management LLC12,000$8.86K0.00%00.0%Unchanged
Tower Research Capital LLC (TRC)12,155$8.98K0.00%+6,184+103.6%Added
Pinnacle Wealth Management Advisory Group, LLC12,445$9.19K0.00%00.0%Unchanged
Mirae Asset Global Investments Co., Ltd.12,046$9.32K0.00%−1,028−7.9%Reduced
HSBC Holdings PLC13,502$9.65K0.00%+13,502New
Captrust Financial Advisors13,358$9.87K0.00%+2,008+17.7%Added
Vermillion & White Wealth Management Group, LLC13,415$9.91K0.01%00.0%Unchanged
Truist Financial Corp14,000$10.3K0.00%+600+4.5%Added
State of Wisconsin Investment Board15,034$11.1K0.00%+2,602+20.9%Added
BNP Paribas Arbitrage, SA19,704$14.6K0.00%−12,149−38.1%Reduced
Tiaa Trust, National Association20,000$14.8K0.00%−7,057−26.1%Reduced
Victory Capital Management Inc20,859$15.4K0.00%−23,448−52.9%Reduced
Cambridge Investment Research Advisors, Inc.23,613$17.0K0.00%+23,613New
JustInvest LLC23,223$17.1K0.00%+3,301+16.6%Added
Citadel Advisors LLC25,832$19.1K0.00%−72,792−73.8%Reduced
KLP Kapitalforvaltning AS26,200$19.3K0.00%+26,200New
Manufacturers Life Insurance Company, The29,646$21.9K0.00%−18,402−38.3%Reduced
Police & Firemen's Retirement System of New Jersey29,715$21.9K0.00%+29,715New
Kestra Advisory Services, LLC31,500$23.3K0.00%+16,000+103.2%Added
New York State Common Retirement Fund33,702$24.9K0.00%00.0%Unchanged
University of Texas/Texas Am Investment Managment Co35,714$26.4K0.00%00.0%Unchanged
Voya Investment Management LLC38,418$28.4K0.00%00.0%Unchanged
Wedbush Securities Inc40,850$30.0K0.00%00.0%Unchanged
Bayesian Capital Management, LP42,000$31.0K0.00%+42,000New
Rpo LLC44,242$32.7K0.04%+44,242New
Great West Life Assurance Co46,013$34.0K0.00%00.0%Unchanged
ProShare Advisors LLC49,460$36.5K0.00%+6,404+14.9%Added
Renaissance Technologies LLC51,141$37.8K0.00%+51,141New
Pathstone Holdings, LLC54,051$39.9K0.00%−4,908−8.3%Reduced
SG Americas Securities, LLC55,308$41.0K0.00%+9,218+20.0%Added
Intech Investment Management LLC56,689$41.9K0.00%−16,751−22.8%Reduced
LPL Financial LLC57,007$42.1K0.00%−6,028−9.6%Reduced
Corebridge Financial, Inc.57,082$42.2K0.00%−4,309−7.0%Reduced
Wells Fargo & Company62,523$46.2K0.00%−13,966−18.3%Reduced
Arizona State Retirement System62,976$46.5K0.00%+16,136+34.4%Added
Dimensional Fund Advisors LP64,966$48.0K0.00%−11,120−14.6%Reduced
Teacher Retirement System of Texas65,415$48.0K0.00%+24,615+60.3%Added
Mirae Asset Global ETFs Holdings Ltd.65,782$48.6K0.00%+2,824+4.5%Added
Bank of Montreal70,000$51.7K0.00%−10.0%Reduced
China Universal Asset Management Co., Ltd.76,650$56.6K0.01%+7,123+10.2%Added
Price T Rowe Associates Inc77,502$57.0K0.00%−39,677−33.9%Reduced
KWB Wealth40,640$63.8K0.01%00.0%Unchanged
JPMorgan Chase & Co87,617$64.7K0.00%−2,083−2.3%Reduced
Virtu Financial LLC88,982$66.0K0.00%+88,982New
Simplex Trading, LLC96,083$71.0K0.00%+96,083New
Cerity Partners LLC96,512$71.3K0.00%+74,000+328.7%Added
Commonwealth Equity Services, LLC101,148$75.0K0.00%−7,586−7.0%Reduced
Invesco Ltd.104,494$77.2K0.00%+39,420+60.6%Added
Citigroup Inc106,786$78.9K0.00%+17,041+19.0%Added
Compagnie Lombard Odier SCmA110,000$81.2K0.00%+10,000+10.0%Added
Legal & General Group Plc111,403$82.3K0.00%00.0%Unchanged
Stifel Financial Corp112,853$83.3K0.00%+60,856+117.0%Added
Bank of America Corp136,407$100.7K0.00%+29,319+27.4%Added
Rhumbline Advisers153,151$113.0K0.00%+7,212+4.9%Added
California State Teachers Retirement System195,215$144.2K0.00%+44,915+29.9%Added
Jane Street Group, LLC220,264$162.7K0.00%+134,903+158.0%Added
Woodline Partners LP229,376$169.4K0.00%−982,548−81.1%Reduced
Barclays PLC243,316$179.7K0.00%+49,443+25.5%Added
Alliancebernstein L.P.246,121$181.8K0.00%−26,920−9.9%Reduced
Group One Trading, L.P.314,404$232.2K0.01%+314,404New
Bank of New York Mellon Corp314,919$232.6K0.00%+1390.0%Added
Deutsche Bank AG315,659$233.6K0.00%+249,616+378.0%Added
UBS Asset Management Americas Inc353,508$261.2K0.00%+233,121+193.6%Added